Results 31 to 40 of about 70,628 (338)

Mechano-transduction: from molecules to tissues. [PDF]

, 2014
External forces play complex roles in cell organization, fate, and homeostasis. Changes in these forces, or how cells respond to them, can result in abnormal embryonic development and diseases in adults.
Dunn, Alexander R, Nelson, W James, Pruitt, Beth L, Weis, William I   +3 more
core   +2 more sources

Cryo-EM captures early ribosome assembly in action

Nature Communications, 2023
The production of ribosomes is a precisely orchestrated energy consuming cellular process of highest priority. Here, the authors use cryo-EM to show that bacterial ribosomal subunits, self-assembled from their purified RNA and protein components, mature ...
Bo Qin, Simon M. Lauer, Annika Balke, Carlos H. Vieira-Vieira, Jörg Bürger, Thorsten Mielke, Matthias Selbach, Patrick Scheerer, Christian M. T. Spahn, Rainer Nikolay   +9 more
doaj   +1 more source

Information processing and signal integration in bacterial quorum sensing

Molecular Systems Biology, 2009
Bacteria communicate using secreted chemical signaling molecules called autoinducers in a process known as quorum sensing. The quorum‐sensing network of the marine bacterium Vibrio harveyi uses three autoinducers, each known to encode distinct ecological
Pankaj Mehta, Sidhartha Goyal, Tao Long, Bonnie L Bassler, Ned S Wingreen   +4 more
doaj   +1 more source

Biophysics at the coffee shop: lessons learned working with George Oster [PDF]

, 2019
Over the past 50 years, the use of mathematical models, derived from physical reasoning, to describe molecular and cellular systems has evolved from an art of the few to a cornerstone of biological inquiry.
Chen, Jing, Elston, Timothy C., Grabe, Michael, Igoshin, Oleg, Kim, Kenneth S., Liu, Jian, Nirody, Jasmine, Rangamani, Padmini, Sun, Sean, Wang, Hongyun, Wolgemuth, Charles, Xing, Jianhua   +11 more
core   +5 more sources

Using mass spectrometry imaging to visualize age-related subcellular disruption

Frontiers in Molecular Biosciences, 2023
Metabolic homeostasis balances the production and consumption of energetic molecules to maintain active, healthy cells. Cellular stress, which disrupts metabolism and leads to the loss of cellular homeostasis, is important in age-related diseases.
Kelly A. Hogan, Kelly A. Hogan, Kelly A. Hogan, Julianna D. Zeidler, Heather K. Beasley, Abrar I. Alsaadi, Abdulkareem A. Alshaheeb, Yi-Chin Chang, Hua Tian, Hua Tian, Antentor O. Hinton, Melanie R. McReynolds, Melanie R. McReynolds   +12 more
doaj   +1 more source

Dorsoventral patterning of the Xenopus eye involves differential temporal changes in the response of optic stalk and retinal progenitors to Hh signalling [PDF]

, 2015
Background: Hedgehog (Hh) signals are instrumental to the dorsoventral patterning of the vertebrate eye, promoting optic stalk and ventral retinal fates and repressing dorsal retinal identity.
G., Barsacchi, Lupo, Giuseppe, R., He, W. A., Harris, X., Wang, Y., Liu   +5 more
core   +1 more source

Evaluation of Pharmacological Rescue of Melanocortin-4 Receptor Nonsense Mutations by Aminoglycoside

Life, 2022
The melanocortin-4 receptor (MC4R) is critical for central satiety regulation, therefore presenting a potent target for pharmacological obesity treatment. Melanocortin-4 receptor mutations prevalently cause monogenetic obesity.
Friederike Höpfner, Sarah Paisdzior, Nanina Reininghaus, Iqra Sohail, Patrick Scheerer, Paolo Annibale, Heike Biebermann, Peter Kühnen   +7 more
doaj   +1 more source

Altered Cell Mechanics from the Inside: Dispersed Single Wall Carbon Nanotubes Integrate with and Restructure Actin

Journal of Functional Biomaterials, 2012
With a range of desirable mechanical and optical properties, single wall carbon nanotubes (SWCNTs) are a promising material for nanobiotechnologies. SWCNTs also have potential as biomaterials for modulation of cellular structures.
Mohammad F. Islam, Kris Noel Dahl, Gustavo K. Rohde, Mohammad R. K. Mofrad, Yu-Li Wang, Brian D. Holt, Hengameh Shams, Travis A. Horst, Saurav Basu, Andrew D. Rape   +9 more
doaj   +1 more source

MicroRNA-100-5p and microRNA-298-5p released from apoptotic cortical neurons are endogenous Toll-like receptor 7/8 ligands that contribute to neurodegeneration

Molecular Neurodegeneration, 2021
Background MicroRNA (miRNA) expression in the brain is altered in neurodegenerative diseases. Recent studies demonstrated that selected miRNAs conventionally regulating gene expression at the post-transcriptional level can act extracellularly as ...
Thomas Wallach, Zoé J. Mossmann, Michal Szczepek, Max Wetzel, Rui Machado, Martin Raden, Milad Miladi, Gunnar Kleinau, Christina Krüger, Paul Dembny, Drew Adler, Yuanyuan Zhai, Victor Kumbol, Omar Dzaye, Jutta Schüler, Matthias Futschik, Rolf Backofen, Patrick Scheerer, Seija Lehnardt   +18 more
doaj   +1 more source

Presence of the GFI1-36N single nucleotide polymorphism enhances the response of MLL-AF9 leukemic cells to CDK4/6 inhibition

Frontiers in Oncology, 2022
The zinc finger protein Growth Factor Independence 1 (GFI1) acts as a transcriptional repressor regulating differentiation of myeloid and lymphoid cells. A single nucleotide polymorphism of GFI1, GFI1-36N, has a prevalence of 7% in healthy Caucasians and
Jan Vorwerk, Kaiyan Sun, Daria Frank, Felix Neumann, Felix Neumann, Jana Hüve, Paulina Marie Budde, Longlong Liu, Xiaoqing Xie, Pradeep Kumar Patnana, Helal Mohammed Mohammed Ahmed, Bertram Opalka, Georg Lenz, Ashok Kumar Jayavelu, Ashok Kumar Jayavelu, Ashok Kumar Jayavelu, Ashok Kumar Jayavelu, Ashok Kumar Jayavelu, Cyrus Khandanpour, Cyrus Khandanpour   +19 more
doaj   +1 more source