Results 31 to 40 of about 170 (96)

High rates of fuel consumption are not required by insulating motifs to suppress retroactivity in biochemical circuits

Engineering Biology, 2017
Retroactivity arises when the coupling of a molecular network [inline-formula] to a downstream network [inline-formula] results in signal propagation back from [inline-formula] to [inline-formula].
Abhishek Deshpande, Thomas E. Ouldridge
doaj   +1 more source

Signal-Induced Inhibition of Telomerase Activity in HL60 Cancer Cells by Signal Transduction Using the Biophysically Activated Regulative Molecule 31 (RM31): A Pilot Study [PDF]

, 2022
Claudia B Klein
openalex   +1 more source

Biophysical characterization of adeno-associated virus capsid through the viral transduction life cycle [PDF]

, 2023
Yanqiao Shawn Xiang, Gang Hao
openalex   +1 more source

An Artificial Intelligent Signal Amplification System for in vivo Detection of miRNA

Frontiers in Bioengineering and Biotechnology, 2019
MicroRNAs (miRNA) have been identified as oncogenic drivers and tumor suppressors in every major cancer type. In this work, we design an artificial intelligent signal amplification (AISA) system including double-stranded SQ (S, signal strand; Q, quencher
Xibo Ma, Xibo Ma, Lei Chen, Yingcheng Yang, Weiqi Zhang, Weiqi Zhang, Peixia Wang, Peixia Wang, Kun Zhang, Kun Zhang, Bo Zheng, Lin Zhu, Lin Zhu, Zheng Sun, Zheng Sun, Shuai Zhang, Shuai Zhang, Yingkun Guo, Minmin Liang, Hongyang Wang, Jie Tian, Jie Tian, Jie Tian   +22 more
doaj   +1 more source

Transcriptional reprogramming by mutated IRF4 in lymphoma

Nature Communications, 2023
Disease-causing mutations in genes encoding transcription factors (TFs) can affect TF interactions with their cognate DNA-binding motifs. Whether and how TF mutations impact upon the binding to TF composite elements (CE) and the interaction with other ...
Nikolai Schleussner, Pierre Cauchy, Vedran Franke, Maciej Giefing, Oriol Fornes, Naveen Vankadari, Salam A. Assi, Mariantonia Costanza, Marc A. Weniger, Altuna Akalin, Ioannis Anagnostopoulos, Thomas Bukur, Marco G. Casarotto, Frederik Damm, Oliver Daumke, Benjamin Edginton-White, J. Christof M. Gebhardt, Michael Grau, Stephan Grunwald, Martin-Leo Hansmann, Sylvia Hartmann, Lionel Huber, Eva Kärgel, Simone Lusatis, Daniel Noerenberg, Nadine Obier, Ulrich Pannicke, Anja Fischer, Anja Reisser, Andreas Rosenwald, Klaus Schwarz, Srinivasan Sundararaj, Andre Weilemann, Wiebke Winkler, Wendan Xu, Georg Lenz, Klaus Rajewsky, Wyeth W. Wasserman, Peter N. Cockerill, Claus Scheidereit, Reiner Siebert, Ralf Küppers, Rudolf Grosschedl, Martin Janz, Constanze Bonifer, Stephan Mathas   +45 more
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The NTD Nanoscope: potential applications and implementations

BMC Bioinformatics, 2011
Background Nanopore transduction detection (NTD) offers prospects for a number of highly sensitive and discriminative applications, including: (i) single nucleotide polymorphism (SNP) detection; (ii) targeted DNA re-sequencing; (iii) protein isoform ...
Horton-Chao Evenie, Winters-Hilt Stephen, Morales Eric   +2 more
doaj   +1 more source

The Axonal Membrane Protein PRG2 Inhibits PTEN and Directs Growth to Branches

Cell Reports, 2019
Summary: In developing neurons, phosphoinositide 3-kinases (PI3Ks) control axon growth and branching by positively regulating PI3K/PI(3,4,5)P3, but how neurons are able to generate sufficient PI(3,4,5)P3 in the presence of high levels of the antagonizing
Annika Brosig, Joachim Fuchs, Fatih Ipek, Cristina Kroon, Sandra Schrötter, Mayur Vadhvani, Alexandra Polyzou, Julia Ledderose, Michiel van Diepen, Hermann-Georg Holzhütter, Thorsten Trimbuch, Niclas Gimber, Jan Schmoranzer, Ivo Lieberam, Christian Rosenmund, Christian Spahn, Patrick Scheerer, Michal Szczepek, George Leondaritis, Britta J. Eickholt   +19 more
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Protocol to investigate G protein-coupled receptor signaling kinetics and concentration-dependent responses using ONE-GO biosensors

STAR Protocols
Summary: ONE vector G protein optical (ONE-GO) biosensors are versatile tools to measure the activity of G protein-coupled receptors (GPCRs) in cells. The availability of ONE-GO biosensors for ten active Gα subunits representative of all four G protein ...
Remi Janicot, Mikel Garcia-Marcos
doaj   +1 more source

AIM for Allostery: Using the Ising Model to Understand Information Processing and Transmission in Allosteric Biomolecular Systems

Entropy, 2015
In performing their biological functions, molecular machines must process and transmit information with high fidelity. Information transmission requires dynamic coupling between the conformations of discrete structural components within the protein ...
Michael V. LeVine, Harel Weinstein
doaj   +1 more source

Collaborative online international learning (COIL): an engaging strategy for narrowing learning distances between two continents

Türk Biyokimya Dergisi
Internationalization is a gold standard of higher education institutions ensuring students’ contact with different environments, including different languages and different cultures.
Cardoso Catarina, Duarte Clara C., Silva Erick J.R., Fardilha Margarida   +3 more
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