Results 51 to 60 of about 35,843 (287)

Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting

Advanced Materials, EarlyView.
CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu, Won Joon Kim, Hyunjin Lee, Xiaoping Bao, Pilnam Kim   +4 more
wiley   +1 more source

High rates of fuel consumption are not required by insulating motifs to suppress retroactivity in biochemical circuits

Engineering Biology, 2017
Retroactivity arises when the coupling of a molecular network [inline-formula] to a downstream network [inline-formula] results in signal propagation back from [inline-formula] to [inline-formula].
Abhishek Deshpande, Thomas E. Ouldridge
doaj   +1 more source

Differentiation of neural-type cells on multi-scale ordered collagen-silica bionanocomposites [PDF]

Biomaterials Science, Royal Society of Chemistry (RSC), 2020, 2020
Cells respond to biophysical and biochemical signals. We developed a composite filament from collagen and silica particles modified to interact with collagen and/or present a laminin epitope (IKVAV) crucial for cell-matrix adhesion and signal transduction.
arxiv  

Simultaneous Isotropic Omnidirectional Hypersensitive Strain Sensing and Deep Learning‐Assisted Direction Recognition in a Biomimetic Stretchable Device

Advanced Materials, EarlyView.
Omnidirectional strain sensing is crucial in healthcare monitoring, human motion detection, and human‐machine interfaces. By mimicking the 3D structure of human fingers, this work introduces a novel heterogeneous substrate incorporating the involute of a circle which enables the device to achieve isotropic omnidirectional hypersensitive strain sensing ...
Muzi Xu, Jiaqi Zhang, Chaoqun Dong, Chenyu Tang, Fangxin Hu, George G. Malliaras, Luigi G. Occhipinti   +6 more
wiley   +1 more source

High-Resolution Plasma Membrane-Selective Imaging by Second Harmonic Generation

iScience, 2018
Summary: The plasma membrane is the site of intercellular communication and subsequent intracellular signal transduction. The specific visualization of the plasma membrane in living cells, however, is difficult using fluorescence-based techniques owing ...
Takaha Mizuguchi, Masato Yasui, Mutsuo Nuriya   +2 more
doaj  

The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins

eLife, 2018
The endoplasmic reticulum (ER) supports biosynthesis of proteins with diverse transmembrane domain (TMD) lengths and hydrophobicity. Features in transmembrane domains such as charged residues in ion channels are often functionally important, but could ...
Matthew J Shurtleff, Daniel N Itzhak, Jeffrey A Hussmann, Nicole T Schirle Oakdale, Elizabeth A Costa, Martin Jonikas, Jimena Weibezahn, Katerina D Popova, Calvin H Jan, Pavel Sinitcyn, Shruthi S Vembar, Hilda Hernandez, Jürgen Cox, Alma L Burlingame, Jeffrey L Brodsky, Adam Frost, Georg HH Borner, Jonathan S Weissman   +17 more
doaj   +1 more source

A Computational Model of YAP/TAZ Mechanosensing [PDF]

Biophysical Journal, 110(11), 2540-2550 (2016), 2016
In cell proliferation, stem cell differentiation, chemoresistance and tissue organization, the ubiquitous role of YAP/TAZ continues to impact our fundamental understanding in numerous physiological and disease systems. YAP/TAZ is an important signaling nexus integrating diverse mechanical and biochemical signals, such as ECM stiffness, adhesion ligand ...
arxiv   +1 more source

DNA‑Directed Assembly of Photonic Nanomaterials for Diagnostic and Therapeutic Applications

Advanced Materials, EarlyView.
DNA‐directed assembly offers a powerful strategy for constructing structured photonic nanomaterials with precise spatial control. This review provides a comprehensive overview of recent advancements in DNA‐assembled photonic nanomaterials for diagnostics and therapeutics, highlighting key design principles, functionalization strategies, and optical ...
Longjiang Ding, Bing Liu, Andreas Peil, Sisi Fan, Jie Chao, Na Liu   +5 more
wiley   +1 more source

Evolutionary analyses reveal immune cell receptor GPR84 as a conserved receptor for bacteria-derived molecules

iScience, 2022
Summary: The G protein-coupled receptor 84 (GPR84) is found in immune cells and its expression is increased under inflammatory conditions. Activation of GPR84 by medium-chain fatty acids results in pro-inflammatory responses.
Amadeus Samuel Schulze, Gunnar Kleinau, Rosanna Krakowsky, David Rochmann, Ranajit Das, Catherine L. Worth, Petra Krumbholz, Patrick Scheerer, Claudia Stäubert   +8 more
doaj  

Lipid bilayer mediates ion-channel cooperativity in a model of hair-cell mechanotransduction [PDF]

Proc Natl Acad Sci USA 114:E11010--E11019 (2017), 2017
Mechanoelectrical transduction in the inner ear is a biophysical process underlying the senses of hearing and balance. The key players involved in this process are mechanosensitive ion channels. They are located in the stereocilia of hair cells and opened by the tension in specialized molecular springs, the tip links, connecting adjacent stereocilia ...
arxiv   +1 more source