Results 51 to 60 of about 411,981 (355)
Cryo-EM captures early ribosome assembly in action
Nature Communications, 2023 The production of ribosomes is a precisely orchestrated energy consuming cellular process of highest priority. Here, the authors use cryo-EM to show that bacterial ribosomal subunits, self-assembled from their purified RNA and protein components, mature ...
Bo Qin +9 more
doaj +1 more source
Structure of the CLC-1 chloride channel from Homo sapiens. [PDF]
, 2018 CLC channels mediate passive Cl- conduction, while CLC transporters mediate active Cl- transport coupled to H+ transport in the opposite direction. The distinction between CLC-0/1/2 channels and CLC transporters seems undetectable by amino acid sequence.
MacKinnon, Roderick, Park, Eunyong
core +2 more sources
Information processing and signal integration in bacterial quorum sensing
Molecular Systems Biology, 2009 Bacteria communicate using secreted chemical signaling molecules called autoinducers in a process known as quorum sensing. The quorum‐sensing network of the marine bacterium Vibrio harveyi uses three autoinducers, each known to encode distinct ecological
Pankaj Mehta +4 more
doaj +1 more source
A synthetic method to assay polycystin channel biophysics
bioRxivIon channels are biological transistors that control ionic flux across cell membranes to regulate electrical transmission and signal transduction. They are found in all biological membranes and their conductive state kinetics are frequently disrupted in ...
Megan Larmore +3 more
semanticscholar +1 more source
Scalable Production of Highly-Sensitive Nanosensors Based on Graphene Functionalized with a Designed G Protein-Coupled Receptor [PDF]
, 2014 We have developed a novel, all-electronic biosensor for opioids that consists of an engineered mu opioid receptor protein, with high binding affinity for opioids, chemically bonded to a graphene field-effect transistor to read out ligand binding.
Crook, Alexander +10 more
core +4 more sources
Regulation of Transmembrane Signaling by Phase Separation.
Annual Review of Biophysics, 2019 Cell surface transmembrane receptors often form nanometer- to micrometer-scale clusters to initiate signal transduction in response to environmental cues.
L. B. Case, Jonathon A. Ditlev, M. Rosen
semanticscholar +1 more source
Using mass spectrometry imaging to visualize age-related subcellular disruption
Frontiers in Molecular Biosciences, 2023 Metabolic homeostasis balances the production and consumption of energetic molecules to maintain active, healthy cells. Cellular stress, which disrupts metabolism and leads to the loss of cellular homeostasis, is important in age-related diseases.
Kelly A. Hogan +12 more
doaj +1 more source
Voltage-clamp fluorometry to record flow-activated PIEZO1 currents and fluorometric signals
STAR ProtocolsSummary: PIEZO channels sense mechanical forces through conformational rearrangements of a mechanosensory domain called blade. To probe these rearrangements in real time, we have inserted conformational-sensitive cyclic-permuted GFP into several ...
Tharaka Wijerathne, Jerome Lacroix
doaj +1 more source
Journal of Functional Biomaterials, 2012 With a range of desirable mechanical and optical properties, single wall carbon nanotubes (SWCNTs) are a promising material for nanobiotechnologies. SWCNTs also have potential as biomaterials for modulation of cellular structures.
Mohammad F. Islam +9 more
doaj +1 more source