Results 71 to 80 of about 70,628 (338)
The NTD Nanoscope: potential applications and implementations
BMC Bioinformatics, 2011 Background Nanopore transduction detection (NTD) offers prospects for a number of highly sensitive and discriminative applications, including: (i) single nucleotide polymorphism (SNP) detection; (ii) targeted DNA re-sequencing; (iii) protein isoform ...
Horton-Chao Evenie +2 more
doaj +1 more source
Entropy, 2015 In performing their biological functions, molecular machines must process and transmit information with high fidelity. Information transmission requires dynamic coupling between the conformations of discrete structural components within the protein ...
Michael V. LeVine, Harel Weinstein
doaj +1 more source
Mice with low levels of Shc proteins display reduced glycolytic and increased gluconeogenic activities in liver. [PDF]
, 2016 Shc proteins play a role in energy metabolism through interaction with the insulin receptor. The aim of this study was to determine whether Shc proteins influence liver glycolysis and gluconeogenesis under both fed and fasted states. Decreased glycolytic
Cortopassi, Gino A +5 more
core +3 more sources
Advanced Healthcare Materials, EarlyView.Extracellular vesicles (EVs) are pivotal mediators of intercellular communication and disease, yet the fundamental mechanisms controlling their biogenesis and cargo selection remain unclear. This limitation hinders their diagnostic utility and therapeutic development.
Luís Carvalho Ferraz +2 more
wiley +1 more source
Machine‐Learning‐Aided Advanced Electrochemical Biosensors
Advanced Materials, EarlyView.Electrochemical biosensors are highly sensitive, portable, and versatile. Advanced nanomaterials enhance their performance, while machine learning (ML) improves data analysis, minimizes interference, and optimizes sensor design. Despite progress in both fields, their combined potential in diagnostics remains underexplored.
Andrei Bocan +9 more
wiley +1 more source
De novo design of a homo-trimeric amantadine-binding protein. [PDF]
, 2019 The computational design of a symmetric protein homo-oligomer that binds a symmetry-matched small molecule larger than a metal ion has not yet been achieved.
Adams +36 more
core +2 more sources
DNA‑Directed Assembly of Photonic Nanomaterials for Diagnostic and Therapeutic Applications
Advanced Materials, EarlyView.DNA‐directed assembly offers a powerful strategy for constructing structured photonic nanomaterials with precise spatial control. This review provides a comprehensive overview of recent advancements in DNA‐assembled photonic nanomaterials for diagnostics and therapeutics, highlighting key design principles, functionalization strategies, and optical ...
Longjiang Ding +5 more
wiley +1 more source
XXVIIth Annual Meeting of the European Chemoreception Research Organization, ECRO 2017 [PDF]
Chemical Senses, 2018 Umami taste perception is mediated by a heterodimeric receptor composed of the two distinct subunits, T1R1 and T1R3. T1R1, and T1R3 subunits are members of the small family of class C GPCRs. Class C GPCRs share a large N-terminal domain (NTD) linked to the transmembrane domain by a cysteine-rich region.
Belloir, Christine +3 more
openaire +6 more sources
Energy integration describes sound-intensity coding in an insect auditory system [PDF]
, 2002 We investigate the transduction of sound stimuli into neural responses and focus on locust auditory receptor cells. As in other mechanosensory model systems, these neurons integrate acoustic inputs over a fairly broad frequency range.
Benda, Jan +3 more
core +2 more sources
The Rise of Mechanobiology for Advanced Cell Engineering and Manufacturing
Advanced Materials, EarlyView.With the growing demand for cell‐based therapies, efficient cellular engineering is crucial. This review calls for greater recognition of mechanobiology principles applied through advanced biomaterial designs, mechanical confinement, and highlights recent advances using micro/nanotechnologies to enhance cell manufacturing.
Huan Ting Ong +8 more
wiley +1 more source