Results 71 to 80 of about 411,981 (355)

Polyphenol alkyl ester inhibits membrane cholesterol domain formation through an antioxidant mechanism based, in nonlinear fashion, on chain length [PDF]

, 2017
Under conditions of oxidative stress, cholesterol aggregates into discrete membrane bilayer domains that precipitate the formation of extracellular crystals, a hallmark feature of the advanced atheroma in cardiovascular disease.
Durand, Erwann, Jacob, Robert F., Mason, R. Preston, Sherratt, Samuel, Villeneuve, Pierre   +4 more
core   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

De novo design of a homo-trimeric amantadine-binding protein. [PDF]

, 2019
The computational design of a symmetric protein homo-oligomer that binds a symmetry-matched small molecule larger than a metal ion has not yet been achieved.
Adams, Afonine, Arzt, Bale, Boyken, Campbell, Davis, Delaglio, DeRose, Dou, Dou, Emsley, Fegan, Ghirlanda, Guerrero, Hsia, Jancarik, Lee, Mallet, McCoy, Meilleur, Mills, Miyamoto, Nyanguile, Ollikainen, Otwinowski, Perez-Lloret, Polizzi, Spencer, Stankunas, Thomaston, Tinberg, Tzeng, Wang, Waudby, Winn, Zhang   +36 more
core   +2 more sources

A Vascular Microphysiological Model of Lung Fibrosis Reveals That Myofibroblasts and IPF Patient‐Derived Fibroblasts Impair Angiogenesis and Vasculogenesis

Advanced Functional Materials, EarlyView.
A microphysiological lung fibrosis model recapitulates myofibroblast–vascular interactions. Induced myofibroblasts and patient‐derived IPF fibroblasts impair angiogenesis and increase vascular permeability via TGF‐β1–driven signaling. Pharmacological interventions with SB 431542 and VEGF supplementation restore vascular morphology and barrier function.
Elena Cambria, Adriana Blazeski, Eunkyung Clare Ko, Tran Thai, Shania Dantes, David A. Barbie, Sarah E. Shelton, Roger D. Kamm   +7 more
wiley   +1 more source

A Setmelanotide-like Effect at MC4R Is Achieved by MC4R Dimer Separation

Biomolecules, 2022
Melanocortin 4 receptor (MC4R) is part of the leptin-melanocortin pathway and plays an essential role in mediating energy homeostasis. Mutations in the MC4R are the most frequent monogenic cause for obesity.
Nanina Reininghaus, Sarah Paisdzior, Friederike Höpfner, Sabine Jyrch, Cigdem Cetindag, Patrick Scheerer, Peter Kühnen, Heike Biebermann   +7 more
doaj   +1 more source

Equations for Stochastic Macromolecular Mechanics of Single Proteins: Equilibrium Fluctuations, Transient Kinetics and Nonequilibrium Steady-State

, 2001
A modeling framework for the internal conformational dynamics and external mechanical movement of single biological macromolecules in aqueous solution at constant temperature is developed.
Qian, Hong
core   +1 more source

Ultrafast Structural Dynamics of BlsA, a Photoreceptor from the Pathogenic Bacterium Acinetobacter baumannii [PDF]

, 2014
Acinetobacter baumannii is an important human pathogen that can form biofilms and persist under harsh environmental conditions. Biofilm formation and virulence are modulated by blue light, which is thought to be regulated by a BLUF protein, BlsA.
Adelbert Bacher, Agnieszka Gil, Allison Haigney, Andras Lukacs, Barth A., Bitrian M., Boris Illarionov, Brust R., Carlos Simmerling, Cheng-Tsung Lai, Decatur S. M., Gaddy J. A., Giamarellou H., Golic A., Gregory M. Greetham, Grinstead J. S., Haigney A., Haigney A., Hasegawa K., Hasegawa K., Ian P. Clark, Jung A., Kiri Addison, Kondo M., Losi A., Lukacs A., Markus Fischer, Masuda S., Masuda S., Masuda S., McQueary C. N., Michael Towrie, Mussi M. A., Pelton J. T., Peter J. Tonge, Richard Brust, Ryu-Ryun Kim, Shahrier Hossain, Stelling A. L., Stephen R. Meech, Suzuki H., Takahashi R., Wu Q., Yuan H., Yuan H., Yuan H.   +45 more
core   +2 more sources

A Smart Bio‐Battery Facilitates Diabetic Bone Defect Repair Via Inducing Macrophage Reprogramming and Synergistically Modulating Bone Remodeling Coupling

Advanced Functional Materials, EarlyView.
This research presents a novel implantable bio‐battery, GF‐OsG, tailored for diabetic bone repair. GF‐OsG generates microcurrents in high‐glucose conditions to enhance vascularization, shift macrophages to the M2 phenotype, and regulate immune responses.
Nanning Lv, Haifu Sun, Wenxiang Tang, Yonggang Li, Zhonglai Qian, Lihui Hong, Chong Chen, Hongye Li, Jiaxiang Bai, Yusen Qiao, Mingming Liu   +10 more
wiley   +1 more source

The Trace Amine-Associated Receptor 1 Agonist 3-Iodothyronamine Induces Biased Signaling at the Serotonin 1b Receptor

Frontiers in Pharmacology, 2018
Trace amine-associated receptors (TAARs) belong to the class A G-protein-coupled receptors (GPCR) and are evolutionary related to aminergic receptors. TAARs have been identified to mediate effects of trace amines.
Julia Bräunig, Juliane Dinter, Carolin S. Höfig, Sarah Paisdzior, Michal Szczepek, Patrick Scheerer, Mark Rosowski, Jens Mittag, Gunnar Kleinau, Gunnar Kleinau, Heike Biebermann   +10 more
doaj   +1 more source

Redox control of multidrug resistance and Its possible modulation by antioxidants [PDF]

, 2016
Clinical efficacy of anticancer chemotherapies is dramatically hampered by multidrug resistance (MDR) dependent on inherited traits, acquired defence against toxins, and adaptive mechanisms mounting in tumours.
Cort, A., De Luca, C., Korkina, L., Ozben, T., Saso, Luciano   +4 more
core   +3 more sources