Results 81 to 90 of about 35,843 (287)

Targeting Senescence with Apigenin Improves Chemotherapeutic Efficacy and Ameliorates Age‐Related Conditions in Mice

Advanced Science, EarlyView.
As a plant‐derived flavonoid, apigenin directly targets PRDX6 to inhibit its PLA2 activity, blocking HSPA8 activation and disturbing its interactions with ATM and p38MAPK in senescent cells. By dampening wide spectrum expression of the SASP, apigenin prevents loss of tissue homeostasis, improves organ function, and alleviates multiple age‐related ...
Hongwei Zhang, Qixia Xu, Zhirui Jiang, Rong Sun, Qun Wang, Sanhong Liu, Xin Luan, Judith Campisi, James L. Kirkland, Weidong Zhang, Yu Sun   +10 more
wiley   +1 more source

Wearable Standalone Sensing Systems for Smart Agriculture

Advanced Science, EarlyView.
This review explores the development and application of wearable sensing systems for plant health monitoring. It examines different types of wearable plant sensors, including their design, working principles, and material choices, with an emphasis on their suitability for real‐world agricultural applications.
Dongpil Kim, Mohammad Zarei, Siyoung Lee, Hansol Lee, Giwon Lee, Seung Goo Lee   +5 more
wiley   +1 more source

Stochastic Distinguishability of Markovian Trajectories [PDF]

J. Chem. Phys. 7 May 2024; 160 (17): 171101
The ability to distinguish between stochastic systems based on their trajectories is crucial in thermodynamics, chemistry, and biophysics. The Kullback-Leibler (KL) divergence, $D_{\text{KL}}^{AB}(0,\tau)$, quantifies the distinguishability between the two ensembles of length-$\tau$ trajectories from Markov processes A and B.
arxiv   +1 more source

Electroactive Electrospun Nanofibrous Scaffolds: Innovative Approaches for Improved Skin Wound Healing

Advanced Science, EarlyView.
This review explores the potential of electroactive electrospun nanofibrous (EEN) scaffolds for enhanced skin wound healing. It discusses how a variety of electroactive materials can be prepared into EEN scaffolds via electrospinning technology, and their applications in various wound types. The review provides insights into the future perspectives for
Yang Zhang, Zhiyuan Zheng, Shilu Zhu, Liang Xu, Qingdong Zhang, Jie Gao, Min Ye, Shuwei Shen, Jinyu Xing, Ming Wu, Ronald X. Xu   +10 more
wiley   +1 more source

Cadherin-13 Deficiency Increases Dorsal Raphe 5-HT Neuron Density and Prefrontal Cortex Innervation in the Mouse Brain

Frontiers in Cellular Neuroscience, 2017
Background: During early prenatal stages of brain development, serotonin (5-HT)-specific neurons migrate through somal translocation to form the raphe nuclei and subsequently begin to project to their target regions.
Andrea Forero, Olga Rivero, Sina Wäldchen, Hsing-Ping Ku, Dominik P. Kiser, Yvonne Gärtner, Laura S. Pennington, Jonas Waider, Patricia Gaspar, Charline Jansch, Frank Edenhofer, Frank Edenhofer, Thérèse J. Resink, Robert Blum, Markus Sauer, Klaus-Peter Lesch, Klaus-Peter Lesch, Klaus-Peter Lesch   +17 more
doaj   +1 more source

Physical constraints for the Stoneham model for light-dependent magnetoreception [PDF]

arXiv, 2014
A new biophysical model for magnetoreception in migratory birds has recently been proposed by Stoneham et al. In this photo-induced radical pair (RP) model the signal transduction mechanism was physical rather than chemical in nature, as otherwise generally assumed in the literature.
arxiv  

Biomineralization‐Inspired Membranization Toward Structural Enhancement of Coacervate Community

Advanced Science, EarlyView.
The spontaneous formation of a mineralized membrane on the surface of coacervate droplets is facilitated by Fe3+ ions and redox reaction, accompanied by the aggregation of the coacervate droplets. These membranized coacervate assemblages not only retain the capacity for biomolecule sequestration and enzyme catalysis but also exhibit enhanced structural
Chunyu Zhao, Xiaoliang Wang, Lianning Li, Hu Huang, Bingzhao Wu, Lei Zhang, Xin Huang   +6 more
wiley   +1 more source

G protein-coupled receptor-mediated calcium signaling in astrocytes [PDF]

arXiv, 2018
Astrocytes express a large variety of G~protein-coupled receptors (GPCRs) which mediate the transduction of extracellular signals into intracellular calcium responses. This transduction is provided by a complex network of biochemical reactions which mobilizes a wealth of possible calcium-mobilizing second messenger molecules.
arxiv  

A Touch Enabled Hemodynamic and Metabolic Monitor

Advanced Science, EarlyView.
This work presents a touch‐based hybrid platform for simultaneous monitoring of vital signs and sweat metabolites. With a simple tri‐finger touch of 4–6 min, users can concurrently get to know their glucose, uric acid, cortisol levels from fingertip sweat, along with blood pressure and heart rate.
Omeed Djassemi, Tamoghna Saha, Ponnusamy Nandhakumar, Muhammad Inam Khan, Hannah Fishman, Sara Earney, Chochanon Moonla, Yuchen Xu, Henry Thai, Sofia Morales‐Fermin, Gyeongho Kim, Rhea Park, Beya Acot, Oscar Wu, Cannon Wurster, An‐Yi Chang, Christopher Cheung, Julia Silberman, Shichao Ding, Joseph Wang   +19 more
wiley   +1 more source

Four-color single-molecule imaging system for tracking GPCR dynamics with fluorescent HiBiT peptide

Biophysics and Physicobiology
Single-molecule imaging provides information on diffusion dynamics, oligomerization, and protein-protein interactions in living cells. To simultaneously monitor different types of proteins at the single-molecule level, orthogonal fluorescent labeling ...
Toshiki Yoda, Yasushi Sako, Asuka Inoue, Masataka Yanagawa   +3 more
doaj   +1 more source