Results 111 to 120 of about 971,477 (354)

MiR-33a Controls hMSCS Osteoblast Commitment Modulating the Yap/Taz Expression Through EGFR Signaling Regulation [PDF]

, 2019
Mesenchymal stromal cells (hMSCs) display a pleiotropic function in bone regeneration. The signaling involved in osteoblast commitment is still not completely understood, and that determines the failure of current therapies being used.
Alessandro, Riccardo, Bellavia, Daniele, Carina, Valeria, Conigliaro, Alice, Costa, Viviana, De Luca, Angela, Fini, Milena, Giavaresi, Gianluca, Raimondi, Lavinia, Salamanna, Francesca   +9 more
core   +1 more source

Mammalian cell transfection: the present and the future

Analytical and Bioanalytical Chemistry, 2010
Transfection is a powerful analytical tool enabling study of the function of genes and gene products in cells. The transfection methods are broadly classified into three groups; biological, chemical, and physical.
T. Kim, J. Eberwine
semanticscholar   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Investigating Gene Function for Neuronal Survival After Metabolic Stress Using Semi-Automated Fluorescence Microscopy and Automated Image Analysis

Frontiers in Molecular Neuroscience, 2018
Overexpression approaches and fluorescence microscopy techniques allow investigating important spatiotemporal aspects of gene regulation as well as quantifying gene function.
Kristin Wendland, Kristin Wendland, Andreas Meisel, Andreas Meisel, Andreas Meisel, Andreas Meisel, Philipp Mergenthaler, Philipp Mergenthaler, Philipp Mergenthaler, Philipp Mergenthaler, Philipp Mergenthaler   +10 more
doaj   +1 more source

Potential Use of Folate-polyethylene glycol (PEG)-Appended Dendrimer (G3) Conjugate with alpha-Cyclodextrin as DNA Carriers to Tumor Cells [PDF]

, 2011
We previously reported that polyamidoamine STARBURST dendrimer (generation 3, G3) (dendrimer) conjugate with alpha-cyclodextrin (alpha-CyD) having an average degree of substitution of 2.4 of alpha-CyD (alpha-CDE) provided remarkable aspects as novel ...
Ayumi Yoshimitsu, Fumitoshi Hirayama, Haruna Ikeda, Hidetoshi Arima, Kaneto Uekama, Keiichi Motoyama, Kenjiro Hattori, Masayo Arizono, Taishi Higashi, Tomoko Takeuchi   +9 more
core   +1 more source

The role of miR-24 as a race related genetic factor in prostate cancer. [PDF]

, 2017
The incidence of prostate cancer (PCa) among African-Americans (AfA) is significantly higher than Caucasian-Americans (CaA) but the genetic basis for this disparity is not known.
Dahiya, Rajvir, Dasgupta, Pritha, Deng, Guoren, Hashimoto, Yutaka, Kato, Taku, Kulkarni, Priyanka, Kumar, Deepak, Majid, Shahana, Mitsui, Yozo, Saini, Sharanjot, Shahryari, Varahram, Shiina, Marisa, Sumida, Mitsuho, Tabatabai, Laura, Tanaka, Yuichiro, Yamamura, Soichiro   +15 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Evaluation of VEGF-111b Anticancer Peptide Production in Transfected Human Cells Using Real time- PCR Analysis

Journal of Mazandaran University of Medical Sciences, 2017
Background and purpose: Endothelial growth factor type b with anti-angiogenic activity and inhibition of tumor growth are considered as new anticancer drugs.
Morteza Sadeghi, Zohreh Hojati
doaj  

The mechanism of high transfection efficiency of human serum albumin conjugated polyethylenimine in A549 cells

Journal of Medical Sciences, 2015
Background: In our previous study, HSA-PEI demonstrated high pDNA transfection efficiency and low cytotoxicity. Materials and Methods: In this study, the relationship between albumin receptors and the high pDNA transfection efficiency of HSA-PEI was ...
Ssu-Wei Peng, Wei-Hsu Ko, Ming-Kung Yeh, Chiao-Hsi Chiang, Jiin-Long Chen   +4 more
doaj   +1 more source

The Role of the Helper Lipid on the DNA Transfection Efficiency of Lipopolyplex Formulations

Scientific Reports, 2014
Multifunctional, lipopolyplex formulations comprising a mixture of cationic liposomes and cationic, receptor-targeting peptides have potential use in gene therapy applications.
Zixiu Du, M. Munye, A. Tagalakis, M. Manunta, S. Hart   +4 more
semanticscholar   +1 more source