Results 161 to 170 of about 585,058 (294)

Protocol for in vitro transfection of mRNA-encapsulated lipid nanoparticles. [PDF]

STAR Protoc
Youn K, Yoo S, Hwang IK, Gil H, Park H, Lee H, Oh S, Keum G, Bang EK.   +8 more
europepmc   +1 more source

Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs

Advanced Healthcare Materials, EarlyView.
Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner, Stefan Keim, Soheil Haddadzadegan, Odile Fernandez Romero, Katrin Zöller, Gabriel Stern, Ilaria Cesi, Krum Kafedjiiski, Andreas Bernkop‐Schnürch   +8 more
wiley   +1 more source

Optimization of Gene Transfection in Murine Myeloma Cell Lines using Different Transfection Reagents.

, 2010
Mahdi Shabani, Shayda Hemmati, Reza Hadavi, Zahra Amirghofran, Mahmood Jeddi‐Tehrani, Hodjattallah Rabbani, Fazel Shokri   +6 more
openalex   +1 more source

Dictyostelium discoideum Expresses a Malaria ChloroquineResistance Mechanism upon Transfection with Mutant, but Not Wild-type,Plasmodium falciparum TransporterPfCRT [PDF]

, 2005
Bronwen Naudé, Joseph Brzostowski, Alan R. Kimmel, Thomas E. Wellems   +3 more
openalex   +1 more source

Photosensitizing Lipid Nanoparticles for Ferroptosis‐Enhanced Photodynamic Cancer Therapy via GPX4 Silencing

Advanced Healthcare Materials, EarlyView.
Photosensitizing lipid nanoparticles (PLNPs) are engineered by incorporating cholesterol–PEG–pheophorbide a into MC3‐based LNPs and encapsulating GPX4‐targeting siRNA. Upon light activation, PLNPs generate reactive oxygen species (ROS) while silencing GPX4 to induce ferroptosis.
Ga‐Hyun Bae, Seungyong Shin, Joo Dong Park, Eun‐Young Koh, Seunghyo Ko, Jieun Han, Chun Gown Park, Dong‐Hyun Kim, Kun Na, Wooram Park   +9 more
wiley   +1 more source

A General RNA Motif for Cellular Transfection [PDF]

, 2012
Maria LB Magalhães, Michelle Byrom, Amy Yan, Linsley Kelly, Na Li, Raquel Furtado, Deborah Palliser, Andrew D. Ellington, Matthew Levy   +8 more
openalex   +1 more source

Transfection [PDF]

, 2020
openaire   +1 more source

A systematic comparison of in-house prepared transfection reagents in the delivery of mRNA or DNA to a wide range of cultured cells. [PDF]

J Biol Chem
Ojha R, Timin E, Szirovicza L, Xu W, Hepojoki J.   +4 more
europepmc   +1 more source

Evaluating the Antiviral Efficacy of Encapsulated PKC Inhibitor BIM‐I against influenza A Virus Infection

Advanced Healthcare Materials, EarlyView.
This study explores nanoparticle delivery of the protein kinase C inhibitor bisindolylmaleimide‐I (BIM‐I) to combat influenza A virus infections. Encapsulation in biodegradable PLGA nanoparticles improved safety while maintaining the compound's strong antiviral activity.
Laura Klement, Jana Ismail, Josefine Schroeder, Amod Godbole, Johanna Schreiber, Christine Weber, Zoltan Cseresnyes, Marc T. Figge, Bettina Löffler, Ulrich S. Schubert, Stephanie Schubert, Christina Ehrhardt, Carsten Hoffmann   +12 more
wiley   +1 more source

Varicella-zoster virus glycoprotein gpI/gpIV receptor: expression, complex formation, and antigenicity within the vaccinia virus-T7 RNA polymerase transfection system [PDF]

, 1993
Zhengbin Yao, Wallen Jackson, Bagher Forghani, Charles Grose   +3 more
openalex   +1 more source