Results 181 to 190 of about 851,785 (340)

PRELIVE: A Framework for Predicting Lipid Nanoparticles In Vivo Efficacy and Reducing Reliance on Animal Testing

Advanced Functional Materials, EarlyView.
PREdicting LNP In Vivo Efficacy (PRELIVE) framework enables the prediction of lipid nanoparticle (LNPs) organ‐specific delivery through dual modeling approaches. Composition‐based models using formulation parameters and protein corona‐based models using biological fingerprints both achieve high predictive accuracy across multiple organs.
Belal I. Hanafy, Chuan‐En Lu, Kai Liu, Audrey Gallud   +3 more
wiley   +1 more source

Enhanced neuronal transfection in the injured brain following systemic delivery of peptide-targeted lipid nanoparticles. [PDF]

Mol Ther Nucleic Acids
Wu JR, Hernandez Y, Canjels A, Bailey KL, Kwon EJ.   +4 more
europepmc   +1 more source

Increased Transfection of the Easily Oxidizable GC-Rich DNA Fragments into the MCF7 Breast Cancer Cell [PDF]

, 2019
Svetlana V. Kostyuk, Н. Н. Мордкович, Н. А. Окорокова, В. П. Вейко, Elena M. Malinovskaya, Elizaveta S. Ershova, Marina S. Konkova, Ekaterina A. Savinova, Maria Borzikova, Т. А. Музаффарова, Lev N. Porokhovnik, Nataly N. Veiko, Serguey I. Kutsev   +12 more
openalex   +1 more source

Transfection [PDF]

, 2020
openaire   +1 more source

Poly(lactic‐co‐glycolic acid) Nanoparticles for IL‐12 Self‐Amplifying RNA Delivery in Glioblastoma Models

Advanced Functional Materials, EarlyView.
xxxx. ABSTRACT Glioblastoma (GBM) remains one of the most lethal brain cancers, with median survival rarely exceeding 15 months after diagnosis. Interleukin‐12 (IL‐12) is a potent immunostimulatory cytokine capable of reshaping the tumor microenvironment (TME), yet its clinical translation is hindered by systemic toxicity and short half‐life. RNA‐based
Fatima Hameedat, Johan Sebastian Lopez‐Parra, Willem M. H. Hoogaars, Emma Dijkstra, Cynthia Huang, Irafasha C. Casmil, Anna K. Blakney, Peter Olinga, Barbara Rothen‐Rutishauser, Hélder A. Santos, Alke Petri‐Fink, Flávia Sousa   +11 more
wiley   +1 more source

Correction: miR-34c-5p targets Notch2 to promote fracture healing. [PDF]

J Orthop Surg Res
Li K, Liu G, Chen F, Sun X, Liu B.
europepmc   +1 more source

Secondary Transient Transfection of Stably Transfected Endothelial Cells [PDF]

BioTechniques, 2000
Reza Forough, James R. Hawker
openaire   +3 more sources

Modular Platform for Rapidly Investigating Long‐Distance Propagation of Human Neural Network Activity

Advanced Healthcare Materials, EarlyView.
This study presents the first human neural organoid culture model capable of rapidly exhibiting long‐distance neural network propagation, thus delivering a system to experimentally investigate large‐scale communication during normal and diseased states.
Megh Dipak Patel, Sailee Sham Lavekar, Ronak Jaisalmeria, Suki Oji, Jazmine Jayasi, Caroline Cvetkovic, Robert Krencik   +6 more
wiley   +1 more source

LncRNA PVT1 targets miR-143-3p to modulate endothelial cell function and thereby participate in deep vein thrombosis (DVT) of the lower limbs. [PDF]

Ann Hematol
Xiang J, Zhang Y, Liu S, Xu Y, Cui W, Tao Y.   +5 more
europepmc   +1 more source

A Human‐Based Skin‐Lymphoreticular Model‐on‐Chip to Emulate Inflammatory Skin Conditions

Advanced Healthcare Materials, EarlyView.
A human‐based lymphoreticular (LR) model was developed through guided self‐assembly and integrated in a skin‐lymphoreticular co‐culture in a microfluidic organ‐on‐chip to mimic interactions between skin and its draining lymph nodes. The human‐based skin‐lymphoreticular model resembles a minimally functional unit that allows to study interactions ...
Zheng Tan, Partho Protim Adhikary, Dana Wörz, Sarah Hedtrich   +3 more
wiley   +1 more source