Results 191 to 200 of about 280,113 (289)

Development of lyophilized mRNA-LNPs with high stability and transfection efficiency in specific cells and tissues. [PDF]

Regen Biomater
Wang T, Yu T, Li W, Chen J, Cheng S, Tian Z, Sung TC, Higuchi A.   +7 more
europepmc   +1 more source

Calcium enhances polyplex-mediated transfection efficiency of plasmid DNA in Jurkat cells. [PDF]

Drug Deliv, 2020
Ayyadevara VSSA, Roh KH.
europepmc   +1 more source

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

Advanced Science, EarlyView.
This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan, Ruolin Zhang, Shihui Ding, Ying Feng, Tao Shen, Ziwei Wang, Wendai Bao, Ke Shui, Jun Qin, Jun Chen, Min Zhang, Zijing Ren, Dongmei Zhao, Xingrong Guo, Zhibing Ai, Xin Yang, Peiyang Zhou, Zhiqiang Dong   +17 more
wiley   +1 more source

Plasmid DNA Delivery to Cancer Cells with Poly(L-lysine)-Based Copolymers Bearing Thermally Sensitive Segments: Balancing Polyplex Tightness, Transfection Efficiency, and Biocompatibility. [PDF]

Pharmaceutics
Kotmakci M, Toncheva-Moncheva N, Tarkavannezhad S, Debelec Butuner B, Dimitrov I, Rangelov S.   +5 more
europepmc   +1 more source

A Cationic Stearamide-based Solid Lipid Nanoparticle for Delivering Yamanaka Factors: Evaluation of the Transfection Efficiency. [PDF]

ChemistryOpen, 2020
Alkan F, Varlı HS, Demirbilek M, Kaplan E, Laçin NT.   +4 more
europepmc   +1 more source

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

Novel electroporation microchip with field constriction enhances transfection efficiency and survival rates of feline embryos. [PDF]

Sci Rep
Kallayanathum W, Techaumnat B, Panklang N, Sripumkhai W, Jeamsaksiri W, Koo O, Jang G, Tharasanit T.   +7 more
europepmc   +1 more source

Effect of Double Substitution in Cationic Chitosan Derivatives on DNA Transfection Efficiency. [PDF]

Polymers (Basel), 2020
Badazhkova VD, Raik SV, Polyakov DS, Poshina DN, Skorik YA.   +4 more
europepmc   +1 more source

IL-21 Optimizes the CAR-T Cell Preparation Through Improving Lentivirus Mediated Transfection Efficiency of T Cells and Enhancing CAR-T Cell Cytotoxic Activities. [PDF]

Front Mol Biosci, 2021
Du L, Nai Y, Shen M, Li T, Huang J, Han X, Wang W, Pang D, Jin A.   +8 more
europepmc   +1 more source

CD4+ Tregs Drive Post‐Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation

Advanced Science, EarlyView.
ABSTRACT Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T‐cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration.
Hang Qu, Cheng Kiu Ho, Jitao Liu, Lei Cui, Yangfeng Hou, Cai Liang, Wenchu Ye, Randolph H. L. Wong, Shohei Hori, Bin Zhou, Kathy O. Lui   +10 more
wiley   +1 more source