Results 81 to 90 of about 1,075,529 (290)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Non-Local Probes Do Not Help with Graph Problems

, 2015
This work bridges the gap between distributed and centralised models of computing in the context of sublinear-time graph algorithms. A priori, typical centralised models of computing (e.g., parallel decision trees or centralised local algorithms) seem to
Göös, Mika, Hirvonen, Juho, Levi, Reut, Medina, Moti, Suomela, Jukka   +4 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Integration of the Barcelona Supercomputing Center for CMS computing: Towards large scale production [PDF]

EPJ Web of Conferences
The CMS experiment is working to integrate an increasing number of High Performance Computing (HPC) resources into its distributed computing infrastructure.
Acosta-Silva C., Delgado Peris A., Flix Molina J., Hernández J.M., Pérez-Calero Yzquierdo A., Pineda Sánchez E., Villalonga Domínguez I.   +6 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

An Assessment of Data Transfer Performance for Large-Scale Climate Data Analysis and Recommendations for the Data Infrastructure for CMIP6

, 2017
We document the data transfer workflow, data transfer performance, and other aspects of staging approximately 56 terabytes of climate model output data from the distributed Coupled Model Intercomparison Project (CMIP5) archive to the National Energy ...
Dart, Eli, Prabhat, Wehner, Michael F.
core  

Fourier Based Fast Multipole Method for the Helmholtz Equation

, 2011
The fast multipole method (FMM) has had great success in reducing the computational complexity of solving the boundary integral form of the Helmholtz equation.
Cecka, Cris, Darve, Eric
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Coherent electronic transfer in quantum dot systems using adiabatic passage

, 2004
We describe a scheme for using an all-electrical, rapid, adiabatic population transfer between two spatially separated dots in a triple-quantum dot system.
A. R. Hamilton, Andrew D. Greentree, C. S. Lent, H. Grabert, Jared H. Cole, Lloyd C. L. Hollenberg, M. A. Nielsen, W. G. van der Wiel   +7 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source