Results 111 to 120 of about 3,668,573 (294)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

The impact of changing to the Global Lung Function Initiative reference equations for transfer factor in paediatrics. [PDF]

ERJ Open Res, 2021
Burns PD, Paton JY.
europepmc   +1 more source

"Transfer Factor": An Update

Experimental Biology and Medicine, 1985
After a short burst of activity following Lawrence's original description of the transfer factor phenomenon (I), interest in this area diminished drastically. Historically, TF was defined functionally as a biochemical entity in dialyzable leukocyte extracts (DLE) which could transfer antigen-specific reactivity as demonstrated by skin testing; it has ...
openaire   +2 more sources

Determination of the characteristic directions of lossless linear optical elements

, 2006
We show that the problem of finding the primary and secondary characteristic directions of a linear lossless optical element can be reformulated in terms of an eigenvalue problem related to the unimodular factor of the transfer matrix of the optical ...
Aben H, Aben H, Asundi A, Born M, Bukhgeim AL, Coker EG, Cook RD, Dankert H, Denisov AM, Ditchburn RW, Engl HW, Fowles GR, Frocht MM, Frocht MM, Fuki AA, Guenther RD, Hammer H, Hanno Hammer *, Hecht E, Helgason S, Holand I, Kirsch A, Longhurst RS, Maxwell JC, Natterer P, Poincaré H, Sommerfeld A, Theocaris PS   +27 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Spectra and Light Curves of GRB Afterglows

, 2004
We performed accurate numerical calculations of angle-, time-, and frequency-dependent radiative transfer for the relativistic motion of matter in gamma-ray burst (GRB) models. Our technique for solving the transfer equation, which is based on the method
A. G. Tolstov, B. L. Jensen, D. Mihalas, E. Waxman, G. B. Rybicki, H. Spruit, J. Granot, J. Granot, K. A. Postnov, K. Z. Stanek, M. J. Rees, M. J. Rees, P. Mészáros, R. A. M. J. Wijers, R. Blandford, R. D. Blandford, R. Sari, S. I. Blinnikov, S. I. Blinnikov, S. I. Blinnikov, T. P. Downes, T. Piran, V. V. Usov   +22 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Neutron charge form factor at large $q^2$

, 2001
The neutron charge form factor $G_{En}(q)$ is determined from an analysis of the deuteron quadrupole form factor $F_{C2}$ data. Recent calculations, based on a variety of different model interactions and currents, indicate that the contributions ...
A. Buchmann, A. Lung, B. Grossetête, B.B. Voitsekhovskii, B.D. Milbrath, C. Herberg, C.D. Buchanan, D. Abbott, D. Benaksas, D. Drickey, D. Ganichot, D. Rohe, F. Martin, F.A. Bumiller, G. Hoehler, G.G. Simon, H. Arenhövel, I. Passchier, I. Sick, I. Sick, J. Becker, J. Friar, J. Goldemberg, J.E. Elias, J.I. Friedman, J.L. Forest, J.W. Van Orden, L.C. Alexa, M. Bouwhuis, M. Ferro-Luzzi, M. Meyerhoff, M. Ostrick, M.K. Jones, P. Stein, P.E. Bosted, R. Cramer, R. Machleidt, R. Schiavilla, R. Schiavilla, R.B. Wiringa, R.E. Rand, R.G. Arnold, R.G. Arnold, R.W. Berard, S. Auffret, S. Galster, S. Platchkov, T. Eden, Yu.K. Akimov   +48 more
core   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source