Results 191 to 200 of about 6,546,888 (243)
Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA
FEBS Open Bio, EarlyView.Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley +1 more source
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty +13 more
wiley +1 more source
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CRC Critical Reviews in Clinical Laboratory Sciences, 1980
It has been more than 30 years since Dr. H. S. Lawrence first reported that it was possible to transfer delayed-type hypersensitivity from sensitized donors to unsensitized recipients with lysates of blood leukocytes. During recent years, research from several laboratories has demonstrated that this effect is immunologically specific.
Charles H. Kirkpatrick, Denis R. Burger
openaire +3 more sources
It has been more than 30 years since Dr. H. S. Lawrence first reported that it was possible to transfer delayed-type hypersensitivity from sensitized donors to unsensitized recipients with lysates of blood leukocytes. During recent years, research from several laboratories has demonstrated that this effect is immunologically specific.
Charles H. Kirkpatrick, Denis R. Burger
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Purification of transfer factors
Molecular Immunology, 1992Transfer factor activities have been studied in both clinical and basic science settings for several decades. Until now, highly purified transfer factors that are suitable for molecular analysis have not been available. This has impeded progress towards understanding the molecular and cellular basis of the activities of these important inducers of cell-
S J, Rozzo, C H, Kirkpatrick
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1994
Cell-mediated immunity (CMI) plays an important role in controlling the proliferation of tumor cells. Since transfer factor (TF) is reportedly able to increase CMI, it was tempting to plan clinical trials whereby transfer factor could be used to increase cancer patients’ cellular immune response to their tumor cells.
G, Pizza, C, De Vinci, H H, Fudenberg
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Cell-mediated immunity (CMI) plays an important role in controlling the proliferation of tumor cells. Since transfer factor (TF) is reportedly able to increase CMI, it was tempting to plan clinical trials whereby transfer factor could be used to increase cancer patients’ cellular immune response to their tumor cells.
G, Pizza, C, De Vinci, H H, Fudenberg
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The Lancet, 1973
Abstract Leucocytes obtained from a donor sensitive to Candida antigen contain a factor (transfer factor) which transfers this sensitivity to non-sensitive recipients. This material is present in the dialysate of leucocyte lysates and can be purified therefrom by gel filtration. This immunologically active component of transfer factor seems to be more
A A, Gottlieb +3 more
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Abstract Leucocytes obtained from a donor sensitive to Candida antigen contain a factor (transfer factor) which transfers this sensitivity to non-sensitive recipients. This material is present in the dialysate of leucocyte lysates and can be purified therefrom by gel filtration. This immunologically active component of transfer factor seems to be more
A A, Gottlieb +3 more
openaire +2 more sources
Transfer Factor in Atopic Dermatitis
Dermatologica, 2009Dialyzable leukocyte extract (transfer factor, TF) from unselected healthy blood donors was given every other week during 1 year to adult patients with severe atopic dermatitis. The results from this double-blind investigation did not reveal any clinical benefit of TF therapy.
Cramers, Marie +5 more
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Immunotherapy With Transfer Factor
JAMA: The Journal of the American Medical Association, 1977Several years ago, H. Sherwood Lawrence, MD, reported that it was possible to transfer delayed-type skin reactivity from sensitive human donors to unreactive recipients, with materials from disrupted blood leukocytes. This finding was in sharp contrast to the previous observations in guinea pigs in which there was an obligatory requirement for living ...
openaire +2 more sources