Results 191 to 200 of about 8,378,733 (308)

Transfer function analysis assesses resting cerebral perfusion metrics using hypoxia-induced deoxyhemoglobin as a contrast agent. [PDF]

Front Physiol, 2023
Sayin ES, Sobczyk O, Poublanc J, Mikulis DJ, Fisher JA, Duffin J.   +5 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Interpreting Modulation Transfer Function in Endoscopic Imaging: Spatial-Frequency Conversion Across Imaging Spaces and the Digital Image Domain with Case Studies. [PDF]

Sensors (Basel)
Wang Q.
europepmc   +1 more source

Point-Counterpoint: Transfer function analysis of dynamic cerebral autoregulation: To band or not to band? [PDF]

J Cereb Blood Flow Metab, 2023
Liu J, Simpson DM, Panerai RB.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Automated Task-Transfer Function Measurement for CT Image Quality Assessment Based on AAPM TG 233. [PDF]

J Imaging
Anam C, Amilia R, Naufal A, Hidayanto E, Sutanto H, Lubis LE, Fujibuchi T, Dougherty G.   +7 more
europepmc   +1 more source

Assessment of cerebrovascular function in patients with sickle cell disease using transfer function analysis. [PDF]

Physiol Rep, 2022
Sayin ES, Sobczyk O, Poublanc J, Mikulis DJ, Fisher JA, Kuo KHM, Duffin J.   +6 more
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

An approach for coherent periodogram averaging of tilt-series data for improved contrast transfer function estimation. [PDF]

FEBS Open Bio
Khavnekar S, Wan W.
europepmc   +1 more source

Biomechanical Modeling of Brachialis-to-Wrist Extensor Muscle Transfer Function for Daily Activities in Tetraplegia. [PDF]

JB JS Open Access, 2022
Son J, Fridén J, Lieber RL.
europepmc   +1 more source