Results 91 to 100 of about 166,135,801 (305)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Heat transfer to impacting drops and post critical heat flux dispersed flow
, 1978 Heat transfer to drops impacting on a hot surface is examined in context of dispersions of flowing, boiling fluids. The liquid contribution to heat transfer from a hot tube to a two-phase dispersion is formulated in terms of heat transfer contributions ...
Kendall, Gail E., Rohsenow, Warren M.
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, 2018 Annual financial report of the Employees Retirement System of Texas documenting income, expenditures, and other relevant financial information for fiscal year ...
Employees Retirement System of Texas
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
AUPE Collective Agreement (April 1, 1984-March 31, 1986)
, 1984 Collective agreement between the Governors of the University of Lethbridge and the Alberta Union of Provincial Employees on behalf of Local 053.AGREEMENT BETWEEN THE GOVERNORS OF THE UNIVERSITY OF LETHBRIDGE AND THE ALBERTA UNION OF PROVINCIAL EMPLOYEES ...
University of Lethbridge ; Alberta Union of Provincial Employees
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بیمارستان, 2016 Background: Concerning to the importance of team learning and process change, the clinical laboratories employees should be familiar with organizational learning.
Hossien Dargahi +2 more
doaj
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Vallis Aurea, 2017 During work one is striving to contribute towards the modelling of emotions of the employees and the dispersion of their emotions as an inevitable process in the creation of positive emotional contagion upon effective change management within a work ...
Sanja Gutic Martincic
doaj +1 more source