Results 1 to 10 of about 401,046 (255)
The Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-like Episode Syndrome-associated Human Mitochondrial tRNALeu(UUR) Mutation Causes Aminoacylation Deficiency and Concomitant Reduced Association of mRNA with Ribosomes [PDF]
, 2000 The pathogenetic mechanism of the mitochondrial tRNALeu(UUR) A3243G transition associated with the mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome has been investigated in transmitochondrial cell lines ...
Attardi, Giuseppe +4 more
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Prebiotic chiral transfer from self-aminoacylating ribozymes may favor either handedness
Nature CommunicationsModern life is essentially homochiral, containing D-sugars in nucleic acid backbones and L-amino acids in proteins. Since coded proteins are theorized to have developed from a prebiotic RNA World, the homochirality of L-amino acids observed in all known ...
Josh Kenchel +10 more
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Mitochondrial DNA. Part B. Resources, 2017 Here, we determined the complete mitogenome of Picromerus griseus, the first for the subfamily Asopinae. This mitochondrial genome contains 16,338 bp, with an A + T content of 71.69%, and contains 37 typical mitochondrial genes (13 protein-coding genes ...
Qing Zhao +5 more
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Lamarck and immunity: Somatic and germline evolution of antibody genes [PDF]
, 2009 Current work on the mechanism of hypermutation of somatically rearranged antibody variable (V) genes shows that the most likely mechanism involves both direct DNA modification (deamination of cytosines to uracils by AID deaminase) and strand nicking plus
Steele, E.J.
core +1 more source
Bioengineering models of cell signaling [PDF]
, 2000 Strategies for rationally manipulating cell behavior in cell-based technologies and molecular therapeutics and understanding effects of environmental agents on physiological systems may be derived from a mechanistic understanding of underlying signaling ...
Asthagiri, Anand R. +1 more
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Transfer RNA and Origins of RNA Interference
Frontiers in Molecular Biosciences, 2021 Andrey Grigoriev
doaj +1 more source
Mitochondrial DNA. Part B. Resources, 2020 The complete chloroplast genome of Chrysosplenium ramosum Maxim. and Chrysosplenium alternifolium L. were reported in this study. The chloroplast genomes were 153,460 bp for C. ramosum and 152,619 bp for C. alternifolium.
Wen-jie Yan +4 more
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Subcellular partitioning of MRP RNA assessed by ultrastructural and biochemical analysis. [PDF]
, 1994 A small RNA encoded within the nucleus is an essential subunit of a RNA processing endonuclease (RNase MRP) hypothesized to generate primers for mitochondrial DNA replication from the heavy strand origin of replication.
Gonzalez, M +6 more
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Controlled evolution of an RNA enzyme [PDF]
It is generally thought that prior to the origin of protein synthesis, life on earth was based on self-replicating RNA molecules. This idea has become especially popular recently due to the discovery of catalytic RNA (ribozymes).
Joyce, G. F.
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Analysis of tRNA halves (tsRNAs) in serum from cattle challenged with bovine viral diarrhea virus
Genetics and Molecular BiologyAcute infections of bovine viral diarrhea virus (BVDV) lead to a range of clinical presentations. Laboratory tests for detection depend on collection of samples during a short viremia. Acutely infected animals remain largely undiagnosed.
Tasia M. Taxis +3 more
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