Results 1 to 10 of about 4,890,054 (416)
Transfer RNA and Origins of RNA Interference [PDF]
Frontiers in Molecular Biosciences, 2021 Almost 30 years ago the first microRNA (miRNA) was detected (Lee et al., 1993), later put in mechanistical context by the discovery of the RNA interference (RNAi) and RNA-induced silencing complex (RISC). miRNA is the variable RISC element (guide) that recognizes messenger RNA (mRNA) targets in the RNAi process facilitated by Argonaute (Ago) proteins ...
Andrey Grigoriev
doaj +7 more sources
Transfer RNA and human disease [PDF]
Frontiers in Genetics, 2014 Pathological mutations in tRNA genes and tRNA processing enzymes are numerous and result in very complicated clinical phenotypes. Mitochondrial tRNA (mt-tRNA) genes are hotspots for pathological mutations and over 200 mt-tRNA mutations have been linked ...
Jamie A Abbott +2 more
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Comparative analysis of RNA families reveals distinct repertoires for each domain of life. [PDF]
PLoS Computational Biology, 2012 The RNA world hypothesis, that RNA genomes and catalysts preceded DNA genomes and genetically-encoded protein catalysts, has been central to models for the early evolution of life on Earth.
Marc P Hoeppner +2 more
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PltRNAdb: Plant transfer RNA database. [PDF]
PLoS ONE, 2022 Transfer RNAs (tRNAs) are intermediate-sized non-coding RNAs found in all organisms that help translate messenger RNA into protein. Recently, the number of sequenced plant genomes has increased dramatically.
Morad M Mokhtar, Achraf El Allali
doaj +3 more sources
A novel mistranslating tRNA model in Drosophila melanogaster has diverse, sexually dimorphic effects [PDF]
G3: Genes, Genomes, Genetics, 2022 Transfer RNAs (tRNAs) are the adaptor molecules required for reading the genetic code and producing proteins. Transfer RNA variants can lead to genome-wide mistranslation, the misincorporation of amino acids not specified by the standard genetic code ...
Joshua R Isaacson +6 more
doaj +3 more sources
Human transfer RNA modopathies: diseases caused by aberrations in transfer RNA modifications. [PDF]
FEBS J, 2021 tRNA molecules are post‐transcriptionally modified by tRNA modification enzymes. Although composed of different chemistries, more than 40 types of human tRNA modifications play pivotal roles in protein synthesis by regulating tRNA structure and stability
Chujo T, Tomizawa K.
europepmc +2 more sources
Transfer RNA-derived small RNAs in the cancer transcriptome [PDF]
Pflügers Archiv: European Journal of Physiology, 2016 The cellular lifetime includes stages such as differentiation, proliferation, division, senescence and apoptosis.These stages are driven by a strictly ordered process of transcription dynamics.
A Dueck +38 more
core +2 more sources
Characterization of Circulating Transfer RNA-Derived RNA Fragments in Cattle
Frontiers in Genetics, 2015 The objective was to characterize naturally occurring circulating transfer RNA-derived RNA Fragments (tRFs) in cattle. Serum from eight clinically normal adult dairy cows was collected, and small non-coding RNAs were extracted immediately after ...
Eduardo eCasas +2 more
doaj +2 more sources
Transfer RNA-derived small RNAs in tumor microenvironment [PDF]
Molecular Cancer, 2023 Transfer RNAs (tRNAs) are a class of non-coding RNAs responsible for amino acid translocation during protein synthesis and are ubiquitously found in organisms.
Mei Yang +5 more
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Transfer RNA Comes of Age [PDF]
RNA, 2015 The year the journal RNA was founded was slated by some in scientific publishing to be the year that one particular type of RNA\u27s run in the spotlight would end.
Ibba, Michael
core +7 more sources