Results 1 to 10 of about 4,677,985 (202)

Transfer RNA-derived small RNAs in tumor microenvironment [PDF]

Molecular Cancer, 2023
Transfer RNAs (tRNAs) are a class of non-coding RNAs responsible for amino acid translocation during protein synthesis and are ubiquitously found in organisms.
Mei Yang, Yongzhen Mo, Daixi Ren, Shun Liu, Zhaoyang Zeng, Wei Xiong   +5 more
doaj   +3 more sources

PltRNAdb: Plant transfer RNA database [PDF]

PLoS ONE, 2022
Transfer RNAs (tRNAs) are intermediate-sized non-coding RNAs found in all organisms that help translate messenger RNA into protein. Recently, the number of sequenced plant genomes has increased dramatically.
Morad M. Mokhtar, Achraf EL Allali
doaj   +4 more sources

tRNAscan-SE 2.0: Improved Detection and Functional Classification of Transfer RNA Genes [PDF]

bioRxiv, 2019
tRNAscan-SE has been widely used for transfer RNA (tRNA) gene prediction for over twenty years, developed just as the first genomes were decoded. With the massive increase in quantity and phylogenetic diversity of genomes, the accurate detection and ...
Patricia P. Chan, Brian Y Lin, Allysia J. Mak, Todd M. Lowe   +3 more
openalex   +2 more sources

Transfer RNA fragments replace microRNA regulators of the cholinergic poststroke immune blockade [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Ischemic stroke triggers peripheral immunosuppression, increasing the susceptibility to poststroke pneumonia that is linked with poor survival.
Katarzyna Winek, Sebastian Lobentanzer, Bettina Nadorp, Serafima Dubnov, Claudia Dames, Sandra Jagdmann, Gilli Moshitzky, Benjamin Hotter, Christian Meisel, David Greenberg, Sagiv Shifman, Jochen Klein, Shani Shenhar‐Tsarfaty, Andreas Meisel, Hermona Soreq   +14 more
openalex   +2 more sources

Characterization of Circulating Transfer RNA-Derived RNA Fragments in Cattle

Frontiers in Genetics, 2015
The objective was to characterize naturally occurring circulating transfer RNA-derived RNA Fragments (tRFs) in cattle. Serum from eight clinically normal adult dairy cows was collected, and small non-coding RNAs were extracted immediately after ...
Eduardo eCasas, Guohong eCai, John D. Neill   +2 more
doaj   +2 more sources

Transfer RNA and human disease

Frontiers in Genetics, 2014
Pathological mutations in tRNA genes and tRNA processing enzymes are numerous and result in very complicated clinical phenotypes. Mitochondrial tRNA (mt-tRNA) genes are hotspots for pathological mutations and over 200 mt-tRNA mutations have been linked ...
Jamie A Abbott, Chris S Francklyn, Susan M Robey-Bond   +2 more
doaj   +2 more sources

A CRISPR-Cas9-based reporter system for single-cell detection of extracellular vesicle-mediated functional transfer of RNA

Nature Communications, 2020
Extracellular vesicles (EV) facilitate intercellular transfer of biological material including RNA, but the regulatory mechanisms for their formation and transfer are incompletely known.
Olivier G. de Jong, Daniel E. Murphy, Imre Mäger, Eduard Willms, Antonio Garcia-Guerra, Jerney J. Gitz-Francois, Juliet Lefferts, Dhanu Gupta, Sander C. Steenbeek, Jacco van Rheenen, Samir El Andaloussi, Raymond M. Schiffelers, Matthew J. A. Wood, Pieter Vader   +13 more
doaj   +2 more sources

Mechanisms of Transfer RNA Fragments Functionality Within and Between Cells and Organisms [PDF]

Cells
Transfer RNA-derived fragments (tRFs) have become a significant category of small non-coding RNAs that likely play vital roles in various cellular functions.
Sathyanarayanan Vaidhyanathan, Yan X. Lin, Adesupo A. Adetowubo, Fatmanur Kiliç, Sai Anusha Jonnalagadda, Andrey Grigoriev   +5 more
doaj   +2 more sources

Transfer RNA-Derived Small Non-Coding RNA: Dual Regulator of Protein Synthesis.

Molecules and Cells, 2019
Transfer RNA-derived small RNAs (tsRNAs) play a role in various cellular processes. Accumulating evidence has revealed that tsRNAs are deeply implicated in human diseases, such as various cancers and neurological disorders, suggesting that tsRNAs should ...
Hak Kyun Kim
openalex   +3 more sources

RNA secondary structure prediction using an ensemble of two-dimensional deep neural networks and transfer learning

Nature Communications, 2019
The limited availability of high-resolution 3D RNA structures for model training limits RNA secondary structure prediction. Here, the authors overcome this challenge by pre-training a DNN on a large set of predicted RNA structures and using transfer ...
Jaswinder Singh, Jack Hanson, Kuldip Paliwal, Yaoqi Zhou   +3 more
doaj   +2 more sources