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Transfer RNA and Origins of RNA Interference [PDF]
Frontiers in Molecular Biosciences, 2021 Almost 30 years ago the first microRNA (miRNA) was detected (Lee et al., 1993), later put in mechanistical context by the discovery of the RNA interference (RNAi) and RNA-induced silencing complex (RISC). miRNA is the variable RISC element (guide) that recognizes messenger RNA (mRNA) targets in the RNAi process facilitated by Argonaute (Ago) proteins ...
Andrey Grigoriev
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Transfer RNA-derived small RNAs in tumor microenvironment [PDF]
Molecular Cancer, 2023 Transfer RNAs (tRNAs) are a class of non-coding RNAs responsible for amino acid translocation during protein synthesis and are ubiquitously found in organisms.
Mei Yang +5 more
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Transfer RNA and human disease [PDF]
Frontiers in Genetics, 2014 Pathological mutations in tRNA genes and tRNA processing enzymes are numerous and result in very complicated clinical phenotypes. Mitochondrial tRNA (mt-tRNA) genes are hotspots for pathological mutations and over 200 mt-tRNA mutations have been linked ...
Jamie A Abbott +2 more
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PltRNAdb: Plant transfer RNA database [PDF]
PLoS ONE, 2022 Transfer RNAs (tRNAs) are intermediate-sized non-coding RNAs found in all organisms that help translate messenger RNA into protein. Recently, the number of sequenced plant genomes has increased dramatically.
Morad M. Mokhtar, Achraf EL Allali
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Human transfer RNA modopathies: diseases caused by aberrations in transfer RNA modifications. [PDF]
FEBS J, 2021 tRNA molecules are post‐transcriptionally modified by tRNA modification enzymes. Although composed of different chemistries, more than 40 types of human tRNA modifications play pivotal roles in protein synthesis by regulating tRNA structure and stability
Chujo T, Tomizawa K.
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Characterization of Circulating Transfer RNA-Derived RNA Fragments in Cattle
Frontiers in Genetics, 2015 The objective was to characterize naturally occurring circulating transfer RNA-derived RNA Fragments (tRFs) in cattle. Serum from eight clinically normal adult dairy cows was collected, and small non-coding RNAs were extracted immediately after ...
Eduardo eCasas +2 more
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Nature Communications, 2020 Extracellular vesicles (EV) facilitate intercellular transfer of biological material including RNA, but the regulatory mechanisms for their formation and transfer are incompletely known.
Olivier G. de Jong +13 more
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The structures and functions of transfer RNA
Progress in Biophysics and Molecular Biology, 1978 Publisher Summary Transfer ribonucleic acid (tRNA) is the term used to describe a group of low molecular weight RNA molecules that play a vital part in protein synthesis Transfer RNAs were assigned the role of adaptor molecules by Hoagland et al.
J.P. Goddard
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Nature Communications, 2019 The limited availability of high-resolution 3D RNA structures for model training limits RNA secondary structure prediction. Here, the authors overcome this challenge by pre-training a DNN on a large set of predicted RNA structures and using transfer ...
Jaswinder Singh +3 more
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