Results 1 to 10 of about 4,926,306 (277)
Transfer RNA-derived small RNAs in the cancer transcriptome [PDF]
Pflügers Archiv: European Journal of Physiology, 2016 The cellular lifetime includes stages such as differentiation, proliferation, division, senescence and apoptosis. These stages are driven by a strictly ordered process of transcription dynamics.
D. Green, W. Fraser, T. Dalmay
semanticscholar +3 more sources
Human transfer RNA modopathies: diseases caused by aberrations in transfer RNA modifications [PDF]
FEBS J, 2020 tRNA molecules are post‐transcriptionally modified by tRNA modification enzymes. Although composed of different chemistries, more than 40 types of human tRNA modifications play pivotal roles in protein synthesis by regulating tRNA structure and stability
T. Chujo, K. Tomizawa
semanticscholar +2 more sources
Transfer RNA and Origins of RNA Interference [PDF]
Frontiers in Molecular Biosciences, 2021 Almost 30 years ago the first microRNA (miRNA) was detected (Lee et al., 1993), later put in mechanistical context by the discovery of the RNA interference (RNAi) and RNA-induced silencing complex (RISC). miRNA is the variable RISC element (guide) that recognizes messenger RNA (mRNA) targets in the RNAi process facilitated by Argonaute (Ago) proteins ...
Grigoriev A.
openaire +6 more sources
Comparative Analysis of RNA Families Reveals Distinct Repertoires for Each Domain of Life [PDF]
PLoS Comput Biol. 2012 8(11):e1002752, 2012 The RNA world hypothesis, that RNA genomes and catalysts preceded DNA genomes and genetically-encoded protein catalysts, has been central to models for the early evolution of life on Earth. A key part of such models is continuity between the earliest stages in the evolution of life and the RNA repertoires of extant lineages.
Gardner, Paul P. +2 more
arxiv +8 more sources
Transfer RNA and human disease [PDF]
Frontiers in Genetics, 2014 Pathological mutations in tRNA genes and tRNA processing enzymes are numerous and result in very complicated clinical phenotypes. Mitochondrial tRNA (mt-tRNA) genes are "hotspots" for pathological mutations and over 200 mt-tRNA mutations have been linked to various disease states. Often these mutations prevent tRNA aminoacylation.
Susan M. Robey-Bond +2 more
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Transfer RNA comes of age [PDF]
RNA, 2015 The year the journal RNA was founded was slated by some in scientific publishing to be the year that one particular type of RNA's run in the spotlight would end. In 1995 I had recently started as a post-doc with Dieter Soll at Yale when he came into the lab to solemnly inform us all that an editor at a certain (S)cience journal had just told him “we ...
Ibba, Michael
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The structures and functions of transfer RNA
Progress in Biophysics and Molecular Biology, 1978 Publisher Summary Transfer ribonucleic acid (tRNA) is the term used to describe a group of low molecular weight RNA molecules that play a vital part in protein synthesis Transfer RNAs were assigned the role of adaptor molecules by Hoagland et al.
J.P. Goddard
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FEMS Microbiology Reviews, 2015 Transfer RNA is an essential adapter molecule that is found across all three domains of life. The primary role of transfer RNA resides in its critical involvement in the accurate translation of messenger RNA codons during protein synthesis and, therefore, ultimately in the determination of cellular gene expression.
Shepherd, Jennifer, Ibba, Michael
openaire +3 more sources
Integrating experimental data with molecular simulations to investigate RNA structural dynamics [PDF]
Curr. Opin. Struct. Biol. 78, 102503 (2023), 2022 Conformational dynamics is crucial for ribonucleic acid (RNA) function. Techniques such as nuclear magnetic resonance, cryo-electron microscopy, small- and wide-angle X-ray scattering, chemical probing, single-molecule F\"orster resonance energy transfer or even thermal or mechanical denaturation experiments probe RNA dynamics at different time and ...
arxiv +1 more source