Results 131 to 140 of about 4,527,665 (350)
Molecular Oncology, EarlyView.Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho +11 more
wiley +1 more source
RELEASE OF TRANSFER RNA DURING PEPTIDE CHAIN ELONGATION
, 1969 Jean Lucas‐Lenard, Anne‐Lise Haenni
openalex +1 more source
A conformational model of serine transfer RNA proposed on the basis of electron microscopy [PDF]
, 1969 L O Frøholm, Bj�rn Reino Olsen
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Molecular Oncology, EarlyView.This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau +9 more
wiley +1 more source
Inhibition of formylmethionyl-transfer RNA binding to ribosomes by tetracycline.
, 1968 Souvarish Sarkar, Robert E. Thach
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The Conformation of Transfer RNA
Kobunshi, 1972 一定の塩基配列で規定される転移リボ核酸(tRNA)は鎖内部での特異的塩基対形成によってクローバー葉形の二次構造をとる。三次元的にはクローバー葉構造が折りたたまれて高次構造を形成するが,その存在は主として熱変性過程の研究から明らかになった。t RNAのコンホメーションの安定化には陽イオン,とりわけ二価金属イオンが大きな効果を示す。Mg++,Mn++,Co++などはtRNAに約20～30個特異的に結合し,その会合定数は103～104の大きさである。ある種のtRNAには生物活性形と変性形が見出され,相互変換には二価イオンが決定的な役割を果す。活性形は約2～3個の二価イオン部位をよけいにもち,変換にはリン酸基の中和を伴うコンホメーション変化が起こると考えられる ...
openaire +3 more sources
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
A novel viral vaccine platform based on engineered transfer RNA. [PDF]
Emerg Microbes Infect, 2023 Wang TY +7 more
europepmc +1 more source
CYTOKININS: DISTRIBUTION IN SPECIES OF YEAST TRANSFER RNA
, 1969 D. J. Armstrong +6 more
openalex +1 more source