Results 231 to 240 of about 868,050 (310)

In Vitro TRANSCRIPTION OF A TRANSFER RNA GENE

, 1970
Violet Daniel, Sara Sarid, J. Beckmann, Uriel Z. Littauer   +3 more
openalex   +1 more source

Modelling Atherosclerotic Plaque Cap Mechanics: Microcalcifications Reduce Mechanical Properties in Mesenchymal Stromal Cell‐Based Model

Advanced Biology, EarlyView.
This study develops a tissue‐engineered model of the atherosclerotic cap using human mesenchymal stromal cells (MSCs). After 2 weeks of culture to produce a collagenous matrix, a mineralizing medium induces microcalcifications over 4 weeks. These constructs, imaged with second harmonic generation microscopy, lead to reduced ultimate stress at rupture ...
Imke L. Jansen, Deniz Şahin, Frank J.H. Gijsen, Eric Farrell, Kim van der Heiden   +4 more
wiley   +1 more source

Microphysiological Glomerular Filtration Barriers: Current Insights, Innovations, and Future Applications

Advanced Biology, EarlyView.
The glomerular filtration barrier (GFB) is the first step of blood filtration by the kidneys. The concerning increase of kidney diseases makes the development of new models essential. In this context, microphysiological glomerular filtration barriers focus on closely reproducing the physiological architecture of the in vivo GFB: podocytes, glomerular ...
Manon Miran, Kieu Ngo, David Buob, Hanna Debiec, Pierre Ronco, Guillaume Perry   +5 more
wiley   +1 more source

Intersection Between Local Anesthetics and Cancer Biology: What Now? Where Are We Going?

Advanced Biology, EarlyView.
Local anesthetics (LAs), widely used in anesthesia, may also play a role in cancer treatment by inhibiting tumor growth, reducing metastasis, and enhancing immune responses. They modulate key pathways like AKT/mTOR and RAS/ERK while affecting angiogenesis and tumor innervation and the immune response.
Eduardo Nunez‐Rodriguez, Hao Zhang, Dhananjay Sah, Juan P. Cata   +3 more
wiley   +1 more source

Investigating the Cellular Effects of GALC Dosing in Enzyme Replacement Therapy for Krabbe Disease Supports the Role of Nanomedicine

Advanced Biology, EarlyView.
A detailed workflow for recombinant GALC production and characterization is presented to support enzyme replacement therapy for Krabbe disease. In vitro assays demonstrate that physiological GALC doses restore enzymatic activity and autophagic flux without affecting cell viability, whereas higher doses impair autophagy and reduce viability.
Ambra Del Grosso, Sara Carpi, Laura Colagiorgio, Miriam De Sarlo, Mariacristina Gagliardi, Marco Cecchini   +5 more
wiley   +1 more source

Transfer RNA derived fragment, tRF-Glu-CTC, aggravates the development of neovascular age-related macular degeneration. [PDF]

Theranostics
Liang Y, Kong L, Zhang Y, Zhang Y, Shi M, Huang J, Kong H, Qi S, Yang Y, Hong J, Zhu M, Zhu X, Sun X, Zhang S, Wu L, Zhao C.   +15 more
europepmc   +1 more source

Initiation Factor 2-Dependent Ribosomal Binding of N -Formylmethionyl-Transfer RNA Without Added Guanosine Triphosphate

, 1972
Rajarshi Mazumder
openalex   +1 more source

Adipose Mesenchymal Stem Cell‐Derived Exosomes in Conjunction with Roflumilast Ameliorate Chronic Kidney Disease Through the Modulation of Fibrosis and Inflammation

Advanced Biology, EarlyView.
The novelty of this study showed that the injection of exosomes produced from ADMSCs in combination with Roflumilast poses a more favorable therapeutic outcome for CKD induced by Adriamycin, compared to therapy with exosomes or Roflumilast alone. Roflumilast and exosomes treatment lowered the expression of the apoptotic, fibrotic, and inflammatory ...
Mohamed Ali, Mohamed H. Sherif, Nashwa Barakat, Bassant Yahia, Ahmed A. Shokeir, Basel Sitohy   +5 more
wiley   +1 more source

Tryptophanyl-Transfer RNA Synthetase Is Involved in a Negative Feedback Loop Mitigating Interferon-γ-Induced Gene Expression. [PDF]

Cells
Lazar I, Livneh I, Ciechanover A, Fabre B.   +3 more
europepmc   +1 more source

Total synthesis of the structural gene for the precursor of a tyrosine suppressor transfer RNA from Escherichia coli. 11. Enzymatic joining to form the total DNA duplex.

, 1976
Ruth K. Kleppe, Tetsuji Sekiya, Peter C. Loewen, Kjell Kleppe, K Agarwal, H. Büchi, Peter Besmer, Marvin H. Caruthers, Peter Cashion, Mati Fridkin, Ernest Jay, Ashok Kumar, Robert C. Miller, Katsumaro Minamoto, Amos Panet, Uttam L. RajBhandary, Baranitharan Ramamoorthy, Nina Y. Sidorova, Tatsuo Takeya, J.H. van de Sande, H. Gobind Khorana   +20 more
openalex   +1 more source