Results 261 to 270 of about 5,671,100 (385)

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Editorial: Synthetic biology and therapeutic applications of transfer RNA. [PDF]

Front Genet
Söll D, O'Donoghue P, Heinemann IU.
europepmc   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Dysregulated transfer RNA-derived small RNAs as potential gastric cancer biomarkers. [PDF]

Exp Biol Med (Maywood)
Yuan J, Gu W, Xu T, Zhang Y, Shen L, Yan J, Guan X, Chu H, Yuan R, Ju S.   +9 more
europepmc   +1 more source

The Neuronal Gene Arc Encodes a Repurposed Retrotransposon Gag Protein that Mediates Intercellular RNA Transfer.

Cell, 2018
Elissa D. Pastuzyn, C. Day, Rachel B Kearns, Madeleine Kyrke-Smith, Andrew V. Taibi, John McCormick, Nathan Yoder, D. Belnap, S. Erlendsson, D. Morado, J. Briggs, C. Feschotte, J. Shepherd   +12 more
semanticscholar   +1 more source

Immune‐Driven Expression in Inclusion Body Myositis With T‐Cell Large Granular Lymphocytic Leukemia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives T‐cell large granular lymphocytic leukemia (T‐LGLL), reported in up to 58% of inclusion body myositis (IBM) patients, is a rare leukemia of cytotoxic or less commonly helper T cells. The range of myopathies in T‐LGLL and the impact of coexisting T‐LGLL in IBM are not well understood. Our objectives are to investigate the spectrum of
Pannathat Soontrapa, Iago Pinal‐Fernandez, Pritikanta Paul, Michael P. Skolka, Margherita Milone, Min Shi, Mithun V. Shah, Maria Casal‐Dominguez, Katherine Pak, Andrew L. Mammen, Teerin Liewluck   +10 more
wiley   +1 more source

Unveiling the hidden world of transfer RNA-derived small RNAs in inflammation. [PDF]

J Inflamm (Lond)
Qiu P, Jiang Q, Song H.
europepmc   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Prediction of the Association between Transfer RNA and Diseases: A Deep Learning Approach Combining Multi-View Graph Convolution and Attention Mechanisms. [PDF]

ACS Omega
Li X, Yao D, Zhang B, Zhan X, Zhang J.
europepmc   +1 more source

Creating bottom-up RNA transfer vehicles from synthetic protein assemblies [PDF]

Wolfgang Wurst, Maren Kirstin Schuhmacher, Christoph Gruber, Christopher M. Lang, Ricardo Ruijpers, Lyupka Mazneykova, Ariane Krus, Barbara Tremmel, Friederike Reinhardt, Karoline Kadletz, Zhe Ma, Lucie Casalta, Dina Yehia Otify, Brice Beinsteiner, Irene van Balken, Leon Hetzel, Juliane Merl‐Pham, Marina Luchner, Lea Krautner, K. Ganea, Natascha Wiesner, Alexander Emrich, Elif Nuran Yağmur, Katrin Rager, Gauhar Sagindykova, Niklas Armbrust, Julian Geilenkeuser, Gil G. Westmeyer, Elvir Bećirović, Martin Biel, Rouzanna Istvánffy, Daniela M. Vogt Weisenhorn, Dong‐Jiunn Jeffery Truong, Marion Jasnin, Fabian J. Theis, Gregor Ebert, Ali Ertürk, Andrea Bähr, Nikolai Klymiuk, Florian Giesert   +39 more
openalex   +1 more source