Mixed Anhydrides at the Intersection Between Peptide and RNA Autocatalytic Sets: Evolution of Biological Coding [PDF]
arXiv, 2022 We present a scenario for the origin of biological coding. In this context, coding is a semiotic relationship between chemical information stored in one location that links to chemical information stored in a separate location. Coding originated by the cooperative interaction of two, originally separate collectively autocatalytic sets, one for nucleic ...
arxiv
Mutation in human selenocysteine transfer RNA selectively disrupts selenoprotein synthesis.
Journal of Clinical Investigation, 2016 Selenium is a trace element that is essential for human health and is incorporated into more than 25 human selenocysteine-containing (Sec-containing) proteins via unique Sec-insertion machinery that includes a specific, nuclear genome-encoded, transfer ...
E. Schoenmakers +15 more
semanticscholar +1 more source
ノロウイルスRNA複製酵素の特性評価と自然淘汰型in vitro進化実験への応用に関する研究 [PDF]
, 2014 埼玉大学博士(学術)93 p.序論........................................................................................................................................5 Chapter I Characterization of Norovirus RNA replicase for in vitro amplification of RNA………11 I-1 ...
アライ, ヒデナオ, 新井, 秀直
core +1 more source
Specific Signal Enhancement on an RNA-Protein Interface by Dynamic Nuclear Polarization [PDF]
, 2023 Sensitivity and specificity are both crucial for the efficient solid-state NMR structure determination of large biomolecules. We present an approach that features both advantages by site-specific enhancement of NMR spectroscopic signals from the protein ...
Aladin, Victoria +4 more
core +1 more source
Observation of a Change in Bend of an RNA Kissing Complex Using the Angular Dependence of Fluorescence Resonance Energy Transfer [PDF]
, 2014 We report on the observation of a change in the bend angle of an RNA kissing complex upon Rop binding using single-molecular-pair FRET. The angular relationship between the dyes, rather than the distance between them, is shown to be responsible for the observed change in energy transfer. It has long been thought that Rop increases the bend angle of the
arxiv +1 more source
Essential role of long non-coding RNAs in de novo chromatin modifications: The genomic address code hypothesis [PDF]
Biophysical Reviews Vol. 9, pp. 73-77 (2017), 2017 The epigenome, i.e. the whole of chromatin modifications, is transferred from mother to daughter cells during cell differentiation. When de novo chromatin modifications (establishment or erasure of, respectively, new or pre-existing DNA methylations and/or histone modifications) are made in a daughter cell, however, it has a different epigenome than ...
arxiv +1 more source
Direct activation of RNA polymerase III transcription by c-Myc
, 2003 The proto-oncogene product c-Myc has a direct role in both metazoan cell growth and division. RNA polymerase III (pol III) is involved in the generation of transfer RNA and 5S ribosomal RNA, and these molecules must be produced in bulk to meet the need ...
Eisenman, R.N. +3 more
core +1 more source
Transfer RNA is highly unstable during early amino acid starvation in Escherichia coli
Nucleic Acids Research, 2016 Due to its long half-life compared to messenger RNA, bacterial transfer RNA is known as stable RNA. Here, we show that tRNAs become highly unstable as part of Escherichia coli's response to amino acid starvation.
S. Svenningsen +4 more
semanticscholar +1 more source
Identity Elements of Archaeal tRNA [PDF]
DNA Research 12, 235--246 (2005), 2005 Features unique to a transfer-RNA are recognized by the corresponding tRNA-synthetase. Keeping this in view we isolate the discriminating features of all archaeal tRNA. These are our identity elements. Further, we investigate tRNA-characteristics that delineate the different orders of archaea.
arxiv +1 more source
Transfer RNA genes experience exceptionally elevated mutation rates. [PDF]
, 2018 Transfer RNAs (tRNAs) are a central component for the biological synthesis of proteins, and they are among the most highly conserved and frequently transcribed genes in all living things.
Corbett-Detig, Russell B +5 more
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