Results 221 to 230 of about 155,620 (276)

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Optimized Method for High-Quality Isolation of Single-Nuclei From Mosquito Fat Body for RNA Sequencing. [PDF]

Bio Protoc
de Carvalho SS, McNinch C, Barillas-Mury C.   +2 more
europepmc   +1 more source

YKT6 Promotes Bladder Cancer Progression by Stabilizing β‐catenin Through USP7‐Mediated Deubiquitination

Advanced Science, EarlyView.
The SNARE protein YKT6 is upregulated in bladder cancer (BLCA), correlating with poor prognosis. YKT6 promotes tumor proliferation and metastasis by activating Wnt/β‐catenin signaling. It recruits Ubiquitin‐Specific Peptidase 7 (USP7) to deubiquitinate and stabilize β‐catenin, enhancing its nuclear accumulation and driving oncogenic gene expression ...
Sheng Tu, Wenzhi Du, Yongwen Luo, Jiageng Shi, Tianyun Liu, Meng Ji, Kangping Xiong, Siming Chen, Fenfang Zhou, Mingxing Li, Jingtian Yu, Gang Wang, Lingao Ju, Yi Zhang, Yu Xiao, Xinghuan Wang, Kaiyu Qian   +16 more
wiley   +1 more source

Non-Coding RNAs as Emerging Biomarkers in Leishmaniasis and Chagas Disease. [PDF]

Trop Med Infect Dis
Ramos Juárez E, Pérez-Campos Mayoral E, Pérez-Campos Mayoral L, Moreno Rodríguez A, Romero-Díaz C, Avendaño-Villegas ME, Santiago Ramírez TS, Martínez Cruz M, Hernández-Morales JL, Bolaños-Hilario LG, Suárez Luna IK, Elizarrarás-Rivas J, García González AA, Cabrera-Fuentes HA, Hernández-Huerta MT, Pérez-Campos E.   +15 more
europepmc   +1 more source

Vitamin D Regulates Olfactory Function via Dual Transcriptional and mTOR‐Dependent Translational Control of Synaptic Proteins

Advanced Science, EarlyView.
Vitamin D (VitD) modulates olfactory function by remodeling dendrodendritic synapses in tufted cells through vitamin D receptor‐dependent transcriptional and translational mechanisms. VitD regulates synaptic protein translation partially via mTOR signaling.
Pengcheng Ren, Renhe Cao, Xiaoshan Ye, Wenbin Pang, Qingshang Bi, Meihui Huang, Qionglin Zhou, Dan Ye, Wei Xiang, Le Xiao   +9 more
wiley   +1 more source

Assembly and comparative analysis of the first complete mitochondrial genome of <i>Citrus medica</i> (Rutaceae). [PDF]

Front Plant Sci
Wu X, Liu H, Liao S, Liu X, Xie T, Zheng L, Hong Y, Chen W, Li T.   +8 more
europepmc   +1 more source

Epstein‐Barr Virus Expressed Long Non‐Coding RNA (lncBARTs) Regulate EBV Latent Genome Replication

Advanced Science, EarlyView.
EBV produces abundant level of lncBARTs, which are essential for maintaining viral genome replication in EBV‐associated cancers. LncBARTs interact with a complex comprising BRD4, CTCF and viral protein EBNA1 at EBV oriP region. This interaction tethers oriP to host chromosomes, facilitating EBV episome replication.
Jiayan Liu, Dittman Lai‐Shun Chung, Larry Ka‐Yue Chow, Shuo Han, Wenkai Yi, Conor J. Cremin, Yingyin Liao, Pui Wang, Bobo Wing‐Yee Mok, Mingfang Ji, Jian Yan, Wei Dai, Honglin Chen   +12 more
wiley   +1 more source

Decoding tRNA dynamics in neuroimmune disorders: mechanistic insights, diagnostic innovations, and therapeutic opportunities. [PDF]

Front Immunol
Liang E, Wang W, Zhang L.
europepmc   +1 more source

Altered blood and keratinocyte microRNA/transfer RNA fragment profiles related to fibromyalgia syndrome and its severity

Christoph Erbacher, Shani Vaknine, Nimrod Madrer, Sofia Weinbender, Dimitar Evdokimov, Stefan Unterecker, Gilli Moshitzky, Claudia Sommer, David Greenberg, Hermona Soreq, Nurcan Üçeyler   +10 more
openalex   +1 more source

Regulatory Roles of Mitochondrial tRNA-Derived Fragments in Cardiovascular Health and Disease. [PDF]

J Am Heart Assoc
Zeng Y, Jiang QL, Jiang J.
europepmc   +1 more source