Results 41 to 50 of about 155,620 (276)

Mutations in Cytosine-5 tRNA Methyltransferases Impact Mobile Element Expression and Genome Stability at Specific DNA Repeats

Cell Reports, 2018
Summary: The maintenance of eukaryotic genome stability is ensured by the interplay of transcriptional as well as post-transcriptional mechanisms that control recombination of repeat regions and the expression and mobility of transposable elements.
Bianca Genenncher, Zeljko Durdevic, Katharina Hanna, Daniela Zinkl, Mehrpouya Balaghy Mobin, Nevcin Senturk, Bruno Da Silva, Carine Legrand, Clément Carré, Frank Lyko, Matthias Schaefer   +10 more
doaj   +1 more source

Transfer- or ‘transmission’-RNA fragments? The roles of tsRNAs in the reproductive system

Molecular Human Reproduction, 2021
ABSTRACTTransfer-RNAs (tRNAs) help ribosomes decode mRNAs and synthesize proteins; however, tRNA fragments produced under certain conditions, known as tRNA-derived small RNAs (tsRNAs), have been found to play important roles in pathophysiological processes. In the reproductive system, tsRNAs are abundant in gametes and embryos and at the maternal–fetal
Hui-Min Li, Xia Tan, Shun Zhang, Jun Yao, Hong-Gang Li   +4 more
openaire   +2 more sources

The RNA Methyltransferase Dnmt2 Is Required for Efficient Dicer-2-Dependent siRNA Pathway Activity in Drosophila

Cell Reports, 2013
Transfer RNA (tRNA) fragmentation in response to stress conditions has been described in many organisms. tRNA fragments have been found in association with small interfering RNA (siRNA) components, but the biological role of these interactions remains ...
Zeljko Durdevic, Mehrpouya Balaghy Mobin, Katharina Hanna, Frank Lyko, Matthias Schaefer   +4 more
doaj   +1 more source

Host tRNA-Derived RNAs Target the 3′Untranslated Region of SARS-CoV-2

Pathogens, 2022
The COVID-19 pandemic revealed a need for new understanding of the mechanisms regulating host–pathogen interactions during viral infection. Transfer RNA-derived RNAs (tDRs), previously called transfer RNA fragments (tRFs), have recently emerged as ...
Emily N. Hendrickson, Marna E. Ericson, Lynne T. Bemis   +2 more
doaj   +1 more source

Identification of transfer RNA-derived fragments and their potential roles in aortic dissection

Genomics, 2021
Emerging evidence suggests that majority of the transfer RNA (tRNA)-derived small RNA, including tRNA-derived fragments (tRFs) and tRNA halves (tiRNAs), play a significant role in the molecular mechanisms underlying some human diseases. However, expression of tRFs/tiRNAs and their potential roles in aortic dissection (AD) remain unclear.
Xiuxiu, Fu, Xingqiang, He, Yanyan, Yang, Shaoyan, Jiang, Shizhong, Wang, Xingang, Peng, Guozhang, Tang, Tingyu, Zong, Xiaolu, Li, Ying, Zhang, Yulin, Zou, Tao, Yu   +11 more
openaire   +2 more sources

Mapping Current Studies of tRNA Fragments onto Disease Landscape

Biomolecules
Transfer-RNA-derived fragments (tRFs) are a relatively recently discovered class of non-coding RNAs derived from both precursor and mature transfer RNAs (tRNAs).
Sathyanarayanan Vaidhyanathan, MacKenna Durbin, Adesupo A. Adetowubo, Lisa H. Do, Sheida Kavehmoghaddam, Sai Anusha Jonnalagadda, Bryan Ramirez Aguilar, Tamin Ortiz-Gomez, Yan X. Lin, Asim Dave, Fatmanur Kiliç, Alexa R. Karp, Mohammed Imthiyas Rahmah, Noor F. Riaz, Nikhila Mandava, Aleece Siner, Andrey Grigoriev   +16 more
doaj   +1 more source

Small RNA populations revealed by blocking rRNA fragments in Drosophila melanogaster reproductive tissues. [PDF]

PLoS ONE, 2018
RNA interference (RNAi) is a complex and highly conserved regulatory mechanism mediated via small RNAs (sRNAs). Recent technical advances in high throughput sequencing have enabled an increasingly detailed analysis of sRNA abundances and profiles in ...
Emily K Fowler, Irina Mohorianu, Damian T Smith, Tamas Dalmay, Tracey Chapman   +4 more
doaj   +1 more source

Mycobacterium tuberculosis Infection Drives Mitochondria-Biased Dysregulation of Host Transfer RNA–Derived Fragments [PDF]

The Journal of Infectious Diseases, 2020
Abstract Background Mycobacterium tuberculosis (Mtb), the bacterium that causes tuberculosis, causes 10 million infections and 1.5 million deaths per year worldwide. The success of Mtb as a human pathogen is directly related to its ability to suppress host responses, which are critical for clearing ...
Monika M, Looney, Yin, Lu, Petros C, Karakousis, Marc K, Halushka   +3 more
openaire   +2 more sources

Non-coding RNAs and epithelial mesenchymal transition in cancer: molecular mechanisms and clinical implications

Journal of Experimental & Clinical Cancer Research, 2022
Epithelial-mesenchymal transition (EMT) is a fundamental process for embryonic development during which epithelial cells acquire mesenchymal characteristics, and the underlying mechanisms confer malignant features to carcinoma cells such as dissemination
Hashem Khanbabaei, Saeedeh Ebrahimi, Juan Luis García-Rodríguez, Zahra Ghasemi, Hossein Pourghadamyari, Milad Mohammadi, Lasse Sommer Kristensen   +6 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source