Results 21 to 30 of about 159,938 (238)

Secretion of Mutant DNA and mRNA by the Exosomes of Breast Cancer Cells

Molecules, 2021
Exosomes are the small vesicles that are secreted by different types of normal and tumour cells and can incorporate and transfer their cargo to the recipient cells. The main goal of the present work was to study the tumour exosomes’ ability to accumulate
Olga E. Andreeva, Yuri Y. Shchegolev, Alexander M. Scherbakov, Ekaterina I. Mikhaevich, Danila V. Sorokin, Margarita V. Gudkova, Irina V. Bure, Ekaterina B. Kuznetsova, Dmitry S. Mikhaylenko, Marina V. Nemtsova, Dmitry V. Bagrov, Mikhail A. Krasil’nikov   +11 more
doaj   +1 more source

Transfer RNA‐derived fragments: origins, processing, and functions [PDF]

WIREs RNA, 2011
AbstractDeep sequencing approaches have revealed multiple types of small RNAs with known and unknown functions. In this review we focus on a recently identified group of small RNAs that are derived from transfer RNAs (tRNAs), tRNA fragments (tRFs). We review the mechanism of their processing and their functions in mammalian cells, and highlight points ...
Andrew, Sobala, Gyorgy, Hutvagner
openaire   +2 more sources

PtRFdb: a database for plant transfer RNA-derived fragments [PDF]

Database, 2018
Transfer RNA-derived fragments (tRFs) represent a novel class of small RNAs (sRNAs) generated through endonucleolytic cleavage of both mature and precursor transfer RNAs (tRNAs). These 14-28 nt length tRFs that have been extensively studied in animal kingdom are to be explored in plants. In this study, we introduce a database of plant tRFs named PtRFdb
Nikita Gupta, Ajeet Singh, Shafaque Zahra, Shailesh Kumar   +3 more
openaire   +2 more sources

Assessing spermatozoal small ribonucleic acids and their relationship to blastocyst development in idiopathic infertile males

Scientific Reports, 2022
Clinical testing strategies for diagnosing male factor infertility are limited. A deeper analysis of spermatozoa-derived factors could potentially diagnose some cases of ‘unexplained infertility’.
Matthew Hamilton, Stewart Russell, Karen Menezes, Sergey I. Moskovtsev, Clifford Librach   +4 more
doaj   +1 more source

Characterisation of the small RNAs in the biomedically important green-bottle blowfly Lucilia sericata. [PDF]

PLoS ONE, 2015
The green bottle fly maggot, Lucilia sericata, is a species with importance in medicine, agriculture and forensics. Improved understanding of this species' biology is of great potential benefit to many research communities.
Cherie Blenkiron, Peter Tsai, Lisa A Brown, Vernon Tintinger, Kathryn J Askelund, John A Windsor, Anthony R Phillips   +6 more
doaj   +1 more source

Transfer- or ‘transmission’-RNA fragments? The roles of tsRNAs in the reproductive system

Molecular Human Reproduction, 2021
ABSTRACTTransfer-RNAs (tRNAs) help ribosomes decode mRNAs and synthesize proteins; however, tRNA fragments produced under certain conditions, known as tRNA-derived small RNAs (tsRNAs), have been found to play important roles in pathophysiological processes. In the reproductive system, tsRNAs are abundant in gametes and embryos and at the maternal–fetal
Hui-Min Li, Xia Tan, Shun Zhang, Jun Yao, Hong-Gang Li   +4 more
openaire   +2 more sources

An Expanded Landscape of Unusually Short RNAs in 11 Samples from Six Eukaryotic Organisms

Non-Coding RNA, 2022
Small RNA sequencing (sRNA-Seq) approaches unveiled sequences derived from longer non-coding RNAs, such as transfer RNA (tRNA) and ribosomal RNA (rRNA) fragments, known as tRFs and rRFs, respectively.
Marine Lambert, Sara Guellal, Jeffrey Ho, Abderrahim Benmoussa, Benoit Laffont, Richard Bélanger, Patrick Provost   +6 more
doaj   +1 more source

Transfer RNA and ribosomal RNA fragments – emerging players in plant–microbe interactions

New Phytologist, 2023
SummaryAccording to current textbooks, the principal task of transfer and ribosomal RNAs (tRNAs and rRNAs, respectively) is synthesizing proteins. During the last decade, additional cellular roles for precisely processed tRNA and rRNAs fragments have become evident in all kingdoms of life. These RNA fragments were originally overlooked in transcriptome
Panstruga, Ralph, Spanu, Pietro
openaire   +3 more sources

The abundance of a transfer RNA-derived RNA fragment small RNA subpopulation is enriched in cauda spermatozoa [PDF]

ExRNA, 2020
AbstractThe small RNA (sRNA) landscape of mammalian spermatozoa is considerably altered as these gametic cells migrate through the segment specific microenvironments of the epididymis. More specifically, the microRNA (miRNA) species of sRNA dominates the sRNA landscape of spermatozoa of the proximal caput segment of the epididymis.
Simone J. Stanger, Ilana R. Bernstein, Amanda L. Anderson, Kate Hutcheon, Matthew D. Dun, Andrew L. Eamens, Brett Nixon   +6 more
openaire   +2 more sources

Transfer RNA-derived fragments in aging Caenorhabditis elegans originate from abundant homologous gene copies

Scientific Reports, 2021
Small RNAs that originate from transfer RNA (tRNA) species, tRNA-derived fragments (tRFs), play diverse biological functions but little is known for their association with aging.
GiWon Shin, Hee Jung Koo, Mihwa Seo, Seung-Jae V. Lee, Hong Gil Nam, Gyoo Yeol Jung   +5 more
doaj   +1 more source