Results 11 to 20 of about 159,938 (238)
Transfer RNA Fragments in the Kidney in Hypertension. [PDF]
Hypertension, 2021 Small noncoding RNAs (sncRNAs) are important regulators of gene expression. In contrast with well-studied microRNAs, transfer RNA-derived RNA fragments (tRFs) are a new class of sncRNAs that has not been studied in hypertension. This study aims to characterize renal tRFs and identify dysregulation and potential role of renal tRFs in ...
Pan X +8 more
europepmc +4 more sources
Editorial: The genome’s rising star: Transfer RNA-derived small fragments
Frontiers in Molecular Biosciences, 2022 Wei Yan
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tatDB: a database of Ago1-mediated targets of transfer RNA fragments. [PDF]
Nucleic Acids Res, 2023 Abstract tRNA-derived fragments (tRFs) are a class of emerging post-transcriptional regulators of gene expression likely binding to the transcripts of target genes. However, only a few tRFs targets have been experimentally validated, making it hard to extrapolate the functions or binding mechanisms of tRFs.
Guan L, Grigoriev A.
europepmc +3 more sources
Emerging roles of transfer RNA fragments in the CNS. [PDF]
BrainAbstract Transfer RNA-derived small RNAs (tsRNAs), previously considered inactive tRNA degradation products, have now been shown to be functional small non-coding RNAs. They may play important roles within the CNS and in brain-body interactions, both during normal developmental stages as well as in diverse brain pathologies.
Winek K, Soreq H.
europepmc +4 more sources
Targeting Fusobacterium nucleatum through chemical modifications of host-derived transfer RNA fragments. [PDF]
ISME J, 2023 Abstract Host mucosal barriers possess an arsenal of defense molecules to maintain host-microbe homeostasis such as antimicrobial peptides and immunoglobulins. In addition to these well-established defense molecules, we recently reported small RNAs (sRNAs)-mediated interactions between human oral keratinocytes and Fusobacterium ...
Yang M +5 more
europepmc +3 more sources
Plant transfer RNA‐derived fragments: Biogenesis and functions [PDF]
Journal of Integrative Plant Biology, 2021 AbstractProcessing of mature transfer RNAs (tRNAs) produces complex populations of tRNA‐derived fragments (tRFs). Emerging evidence shows that tRFs have important functions in bacteria, animals, and plants. Here, we review recent advances in understanding plant tRFs, focusing on their biological and cellular functions, such as regulating stress ...
Xuan Ma, Chunyan Liu, Xiaofeng Cao
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tRFtarget: a database for transfer RNA-derived fragment targets [PDF]
Nucleic Acids Research, 2020 AbstractTransfer RNA-derived fragments (tRFs) are a new class of small non-coding RNAs and play important roles in biological and physiological processes. Prediction of tRF target genes and binding sites is crucial in understanding the biological functions of tRFs in the molecular mechanisms of human diseases.
Ningshan Li +3 more
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Vaccines, 2023 The potential of viruses as appropriate vectors for the development of new therapeutic strategies, as well as for the design of molecular (DNA, RNA, and/or protein) vaccines via substitution of nucleotide sequences, has been proven.
Iskra Sainova +5 more
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Di-san junyi daxue xuebao, 2021 Objective To investigate the effect of tRNA fragment differentially expressed between high and low malignant bladder urothelial carcinoma (BUC) cells induced by heat injury on the proliferation and invasion of BUC cells.
JIANG Li +6 more
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ASSOCIATION BETWEEN TRANSFER RNA-DERIVED FRAGMENTS AND VARICOCELE
Fertility and Sterility, 2023 Öz bulunamadı.
Mahmutoglu, Asli Metin +4 more
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