Targeting Fusobacterium nucleatum through chemical modifications of host-derived transfer RNA fragments. [PDF]
ISME J, 2023 Abstract Host mucosal barriers possess an arsenal of defense molecules to maintain host-microbe homeostasis such as antimicrobial peptides and immunoglobulins. In addition to these well-established defense molecules, we recently reported small RNAs (sRNAs)-mediated interactions between human oral keratinocytes and Fusobacterium ...
Yang M +5 more
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Biogenesis and Function of Transfer RNA-Related Fragments (tRFs) [PDF]
Trends in Biochemical Sciences, 2016 Noncoding small RNAs arise from the various un-annotated and annotated regions of the genome. When they arise from annotated genes, the noncoding small RNAs are functionally different from the parent genes. This is a brief review of one class of noncoding small RNAs, tRNA-related fragments (tRFs), which are generated from tRNA. tRFs have been suggested
Anindya Dutta, Canan Kuscu
exaly +3 more sources
The MIME-seq technique allows to monitor the interaction of small non-coding RNAs with Argonaute proteins and their transfer to other cells [PDF]
Scientific ReportsThe MIME-seq2.0 technique utilizes a chimeric methyltransferase engineered to bind Argonaute proteins (hereafter referred to MIME enzyme) to protect the terminal sugar of small non-coding RNAs (sncRNAs) from oxidation, a reaction that inhibits unmodified
Jérôme Perrard +3 more
doaj +3 more sources
Transfer RNA-Derived Fragments and isomiRs Are Novel Components of Chronic TBI-Induced Neuropathology [PDF]
Biomedicines, 2022 Neuroinflammation is a secondary injury mechanism that evolves in the brain for months after traumatic brain injury (TBI). We hypothesized that an altered small non-coding RNA (sncRNA) signature plays a key role in modulating post-TBI secondary injury ...
Noora Puhakka +3 more
doaj +3 more sources
Identification of transfer RNA-derived fragments and their potential roles in aortic dissection
Genomics, 2021 Emerging evidence suggests that majority of the transfer RNA (tRNA)-derived small RNA, including tRNA-derived fragments (tRFs) and tRNA halves (tiRNAs), play a significant role in the molecular mechanisms underlying some human diseases. However, expression of tRFs/tiRNAs and their potential roles in aortic dissection (AD) remain unclear.
Tao Yu, Xiuxiu Fu, Yanyan Yang
exaly +3 more sources
Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human Diseases [PDF]
Genomics & Informatics, 2015 tRNA-derived RNA fragments (tRFs) are an emerging class of non-coding RNAs (ncRNAs). A growing number of reports have shown that tRFs are not random degradation products but are functional ncRNAs made of specific tRNA cleavage. They play regulatory roles
Yu Fu +3 more
doaj +3 more sources
Comprehensive analysis of the complete mitochondrial genome of Distylium chinense [PDF]
Frontiers in Plant ScienceIntroductionDistylium chinense is a flood-tolerant woody species distributed in the hydro-fluctuation zone of the Three Gorges Reservoir in the Yangtze River basin and plays an important role in regional ecological restoration.
Bo Ding +7 more
doaj +2 more sources
Biochimica Et Biophysica Acta - Gene Regulatory Mechanisms, 2018 Ribosome-associated noncoding (ranc) RNAs are a novel class of short regulatory RNAs with functions and origins that have not been well studied. In this present study, we functionally characterized the molecular activity of Saccharomyces cerevisiae transfer RNA (tRNA)-derived fragments (tRFs) during protein biosynthesis.
Anna Maria Mleczko, Kamilla Grzywacz
exaly +3 more sources
Protocol for rapid tRNA enrichment and chemiluminescent northern blot detection of tRNA and tRNA-derived fragments [PDF]
STAR ProtocolsSummary: Transfer RNA (tRNA), its post-transcriptional modifications, and tRNA-derived fragments (tRFs) play essential roles in cellular processes and gene regulation.
Pavlina Gregorova +3 more
doaj +2 more sources
Impact of interspecies colostrum and milk replacement on circulating sncRNA dynamics of neonatal goat kids [PDF]
RNA BiologyReplacing maternal colostrum and milk with those from other species is common practice in neonatal ruminant management, but the effects on small non-coding RNA (sncRNA) transmission remain poorly understood.
Rob J. Dekker +7 more
doaj +2 more sources