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Mechanisms of Transfer RNA Fragments Functionality Within and Between Cells and Organisms [PDF]

Cells
Transfer RNA-derived fragments (tRFs) have become a significant category of small non-coding RNAs that likely play vital roles in various cellular functions.
Sathyanarayanan Vaidhyanathan, Yan X. Lin, Adesupo A. Adetowubo, Fatmanur Kiliç, Sai Anusha Jonnalagadda, Andrey Grigoriev   +5 more
doaj   +7 more sources

Characterization of Circulating Transfer RNA-Derived RNA Fragments in Cattle [PDF]

Frontiers in Genetics, 2015
The objective was to characterize naturally occurring circulating transfer RNA-derived RNA Fragments (tRFs) in cattle. Serum from eight clinically normal adult dairy cows was collected, and small non-coding RNAs were extracted immediately after ...
Eduardo eCasas, Guohong eCai, John D. Neill   +2 more
doaj   +5 more sources

Transfer RNA-Derived Fragments, the Underappreciated Regulatory Small RNAs in Microbial Pathogenesis [PDF]

Frontiers in Microbiology, 2021
In eukaryotic organisms, transfer RNA (tRNA)-derived fragments have diverse biological functions. Considering the conserved sequences of tRNAs, it is not surprising that endogenous tRNA fragments in bacteria also play important regulatory roles.
Zhongyou Li, Bruce A. Stanton
doaj   +5 more sources

tRFdb: a database for transfer RNA fragments [PDF]

Nucleic Acids Research, 2015
We have created tRFdb, the first database of transfer RNA fragments (tRFs), available at http://genome.bioch.virginia.edu/trfdb/. With over 100 small RNA libraries analyzed, the database currently contains the sequences and read counts of the three classes of tRFs for eight species: R. sphaeroides, S. pombe, D. melanogaster, C.
Suresh Mudunuri, Anindya Dutta, Jordan Anaya   +2 more
exaly   +5 more sources

Transfer RNA fragments replace microRNA regulators of the cholinergic poststroke immune blockade [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Ischemic stroke triggers peripheral immunosuppression, increasing the susceptibility to poststroke pneumonia that is linked with poor survival. The poststroke brain initiates intensive communication with the immune system, and acetylcholine contributes to these messages; but the responsible molecules ...
Jochen Klein, Andreas Meisel, Serafima Dubnov   +2 more
exaly   +5 more sources

Association of Circulating Transfer RNA fragments with antibody response to Mycoplasma bovis in beef cattle [PDF]

BMC Veterinary Research, 2018
Background High throughput sequencing allows identification of small non-coding RNAs. Transfer RNA Fragments are a class of small non-coding RNAs, and have been identified as being involved in inhibition of gene expression.
Eduardo Casas, Guohong Cai, Larry A. Kuehn, Karen B. Register, Tara G. McDaneld, John D. Neill   +5 more
doaj   +4 more sources

Transfer RNA Fragments in the Kidney in Hypertension. [PDF]

Hypertension, 2021
Small noncoding RNAs (sncRNAs) are important regulators of gene expression. In contrast with well-studied microRNAs, transfer RNA-derived RNA fragments (tRFs) are a new class of sncRNAs that has not been studied in hypertension. This study aims to characterize renal tRFs and identify dysregulation and potential role of renal tRFs in ...
Pan X, Geng X, Liu Y, Yu M, Mishra MK, Xu X, Ding X, Liu P, Liang M.   +8 more
europepmc   +4 more sources

tatDB: a database of Ago1-mediated targets of transfer RNA fragments. [PDF]

Nucleic Acids Res, 2023
Abstract tRNA-derived fragments (tRFs) are a class of emerging post-transcriptional regulators of gene expression likely binding to the transcripts of target genes. However, only a few tRFs targets have been experimentally validated, making it hard to extrapolate the functions or binding mechanisms of tRFs.
Guan L, Grigoriev A.
europepmc   +3 more sources

Emerging roles of transfer RNA fragments in the CNS. [PDF]

Brain
Abstract Transfer RNA-derived small RNAs (tsRNAs), previously considered inactive tRNA degradation products, have now been shown to be functional small non-coding RNAs. They may play important roles within the CNS and in brain-body interactions, both during normal developmental stages as well as in diverse brain pathologies.
Winek K, Soreq H.
europepmc   +4 more sources

Transfer RNA Fragments in Diseases of Sensory Organs. [PDF]

Int J Mol Sci
Transfer RNA-derived fragments (tRFs) have been recently recognized for their multiple roles in gene expression, including modulation of translation, mRNA stability, and cellular signaling pathways. Sensory organs, such as the eyes, skin, and oral cavity, are continuously exposed to environmental stressors, including oxidative stress, ultraviolet ...
Gulati N, Yang Z, Lin YX, Sanusi H, Gonda B, McNally DC, Stellwag A, Holmes MC, Chaudhary R, Stevenson J, Lepouski K, Johnson-Kleinpeter L, Vaidhyanathan S, Solesio ME, Grigoriev A.   +14 more
europepmc   +2 more sources