Transfer RNA-Derived Fragments, the Underappreciated Regulatory Small RNAs in Microbial Pathogenesis [PDF]
Frontiers in Microbiology, 2021 In eukaryotic organisms, transfer RNA (tRNA)-derived fragments have diverse biological functions. Considering the conserved sequences of tRNAs, it is not surprising that endogenous tRNA fragments in bacteria also play important regulatory roles.
Zhongyou Li, Bruce A. Stanton
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Characterization of Circulating Transfer RNA-Derived RNA Fragments in Cattle [PDF]
Frontiers in Genetics, 2015 The objective was to characterize naturally occurring circulating transfer RNA-derived RNA Fragments (tRFs) in cattle. Serum from eight clinically normal adult dairy cows was collected, and small non-coding RNAs were extracted immediately after ...
Eduardo eCasas +2 more
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Mechanisms of Transfer RNA Fragments Functionality Within and Between Cells and Organisms [PDF]
CellsTransfer RNA-derived fragments (tRFs) have become a significant category of small non-coding RNAs that likely play vital roles in various cellular functions.
Sathyanarayanan Vaidhyanathan +5 more
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Association of Circulating Transfer RNA fragments with antibody response to Mycoplasma bovis in beef cattle [PDF]
BMC Veterinary Research, 2018 Background High throughput sequencing allows identification of small non-coding RNAs. Transfer RNA Fragments are a class of small non-coding RNAs, and have been identified as being involved in inhibition of gene expression.
Eduardo Casas +5 more
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tRFdb: a database for transfer RNA fragments [PDF]
Nucleic Acids Research, 2015 We have created tRFdb, the first database of transfer RNA fragments (tRFs), available at http://genome.bioch.virginia.edu/trfdb/. With over 100 small RNA libraries analyzed, the database currently contains the sequences and read counts of the three classes of tRFs for eight species: R. sphaeroides, S. pombe, D. melanogaster, C.
Pankaj Kumar +2 more
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Transfer RNA fragments replace microRNA regulators of the cholinergic poststroke immune blockade [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Ischemic stroke triggers peripheral immunosuppression, increasing the susceptibility to poststroke pneumonia that is linked with poor survival. The poststroke brain initiates intensive communication with the immune system, and acetylcholine contributes to these messages; but the responsible molecules ...
Katarzyna Winek +2 more
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Protocol for rapid tRNA enrichment and chemiluminescent northern blot detection of tRNA and tRNA-derived fragments [PDF]
STAR ProtocolsSummary: Transfer RNA (tRNA), its post-transcriptional modifications, and tRNA-derived fragments (tRFs) play essential roles in cellular processes and gene regulation.
Pavlina Gregorova +3 more
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Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human Diseases [PDF]
Genomics & Informatics, 2015 tRNA-derived RNA fragments (tRFs) are an emerging class of non-coding RNAs (ncRNAs). A growing number of reports have shown that tRFs are not random degradation products but are functional ncRNAs made of specific tRNA cleavage. They play regulatory roles
Yu Fu +3 more
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Transfer RNA-Derived Fragments and isomiRs Are Novel Components of Chronic TBI-Induced Neuropathology [PDF]
Biomedicines, 2022 Neuroinflammation is a secondary injury mechanism that evolves in the brain for months after traumatic brain injury (TBI). We hypothesized that an altered small non-coding RNA (sncRNA) signature plays a key role in modulating post-TBI secondary injury ...
Noora Puhakka +3 more
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Association of Transfer RNA Fragments in White Blood Cells With Antibody Response to Bovine Leukemia Virus in Holstein Cattle [PDF]
Frontiers in Genetics, 2018 Bovine leukemia virus (BLV) affects cattle health and productivity worldwide, causing abnormal immune function and immunosuppression. Transfer RNA fragments (tRFs) are known to be involved in inhibition of gene expression and have been associated with ...
Tasia M. Taxis +4 more
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