Results 31 to 40 of about 159,938 (238)
tRFtarget 2.0: expanding the targetome landscape of transfer RNA-derived fragments
Nucleic Acids Research, 2023 Abstract tRFtarget 1.0 (http://trftarget.net/) is a platform consolidating both computationally predicted and experimentally validated binding sites between transfer RNA-derived fragments (tRFs) and target genes (or transcripts) across multiple organisms.
Ningshan Li +4 more
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Widespread mitovirus sequences in plant genomes [PDF]
PeerJ, 2015 The exploration of the evolution of RNA viruses has been aided recently by the discovery of copies of fragments or complete genomes of non-retroviral RNA viruses (Non-retroviral Endogenous RNA Viral Elements, or NERVEs) in many eukaryotic nuclear genomes.
Jeremy A. Bruenn +2 more
doaj +2 more sources
Frontiers in Microbiology, 2021 Respiratory syncytial virus (RSV) or measles virus (MeV) infection modifies host responses through small non-coding RNA (sncRNA) expression. We show that RSV or MeV infection of neuronal cells induces sncRNAs including various microRNAs and transfer RNA ...
Abhijeet A. Bakre +5 more
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Horizontal transfer between loose compartments stabilizes replication of fragmented ribozymes.
PLoS Computational Biology, 2019 The emergence of replicases that can replicate themselves is a central issue in the origin of life. Recent experiments suggest that such replicases can be realized if an RNA polymerase ribozyme is divided into fragments short enough to be replicable by ...
Atsushi Kamimura +3 more
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Recent development of urinary biomarkers for bladder cancer diagnosis and monitoring
Clinical and Translational Discovery, 2023 Urine‐based liquid biopsy has emerged as a non‐invasive and effective tool for early screening and diagnosis of bladder cancer. This review provides a comprehensive overview of the current urine‐based biomarkers and methods for the detection and ...
Yuchen Zeng +11 more
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Cell Reports, 2018 Summary: The maintenance of eukaryotic genome stability is ensured by the interplay of transcriptional as well as post-transcriptional mechanisms that control recombination of repeat regions and the expression and mobility of transposable elements.
Bianca Genenncher +10 more
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Transfer RNA-derived fragments as novel biomarkers of the onset and progression of gastric cancer
Experimental Biology and Medicine, 2023 Gastric cancer (GC) is a particularly malignant disease; thus, early diagnosis and treatment are especially important. Transfer RNA-derived small RNAs (tsRNAs) have been implicated in the onset and progression of various cancers. Therefore, the aim of this study was to explore the role of tRF-18-79MP9P04 (previously named tRF-5026a) in the onset and ...
Yaoyao Xie +4 more
openaire +2 more sources
Mapping Current Studies of tRNA Fragments onto Disease Landscape
BiomoleculesTransfer-RNA-derived fragments (tRFs) are a relatively recently discovered class of non-coding RNAs derived from both precursor and mature transfer RNAs (tRNAs).
Sathyanarayanan Vaidhyanathan +16 more
doaj +1 more source
Cell Reports, 2013 Transfer RNA (tRNA) fragmentation in response to stress conditions has been described in many organisms. tRNA fragments have been found in association with small interfering RNA (siRNA) components, but the biological role of these interactions remains ...
Zeljko Durdevic +4 more
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Host tRNA-Derived RNAs Target the 3′Untranslated Region of SARS-CoV-2
Pathogens, 2022 The COVID-19 pandemic revealed a need for new understanding of the mechanisms regulating host–pathogen interactions during viral infection. Transfer RNA-derived RNAs (tDRs), previously called transfer RNA fragments (tRFs), have recently emerged as ...
Emily N. Hendrickson +2 more
doaj +1 more source