Results 41 to 50 of about 168,857 (234)

Recent development of urinary biomarkers for bladder cancer diagnosis and monitoring

Clinical and Translational Discovery, 2023
Urine‐based liquid biopsy has emerged as a non‐invasive and effective tool for early screening and diagnosis of bladder cancer. This review provides a comprehensive overview of the current urine‐based biomarkers and methods for the detection and ...
Yuchen Zeng, Anqi Wang, Wei Lv, Qingqing Wang, Shiqi Jiang, Xiaoguang Pan, Fei Wang, Huanming Yang, Lars Bolund, Chunhua Lin, Peng Han, Yonglun Luo   +11 more
doaj   +1 more source

Mapping Current Studies of tRNA Fragments onto Disease Landscape

Biomolecules
Transfer-RNA-derived fragments (tRFs) are a relatively recently discovered class of non-coding RNAs derived from both precursor and mature transfer RNAs (tRNAs).
Sathyanarayanan Vaidhyanathan, MacKenna Durbin, Adesupo A. Adetowubo, Lisa H. Do, Sheida Kavehmoghaddam, Sai Anusha Jonnalagadda, Bryan Ramirez Aguilar, Tamin Ortiz-Gomez, Yan X. Lin, Asim Dave, Fatmanur Kiliç, Alexa R. Karp, Mohammed Imthiyas Rahmah, Noor F. Riaz, Nikhila Mandava, Aleece Siner, Andrey Grigoriev   +16 more
doaj   +1 more source

Mutations in Cytosine-5 tRNA Methyltransferases Impact Mobile Element Expression and Genome Stability at Specific DNA Repeats

Cell Reports, 2018
Summary: The maintenance of eukaryotic genome stability is ensured by the interplay of transcriptional as well as post-transcriptional mechanisms that control recombination of repeat regions and the expression and mobility of transposable elements.
Bianca Genenncher, Zeljko Durdevic, Katharina Hanna, Daniela Zinkl, Mehrpouya Balaghy Mobin, Nevcin Senturk, Bruno Da Silva, Carine Legrand, Clément Carré, Frank Lyko, Matthias Schaefer   +10 more
doaj   +1 more source

Advances of transfer RNA-derived fragments in age-related diseases

Shiyong laonian yixue
Transfer RNA-derived fragments (tRFs), generated through specific nuclease cleavage of transfer RNAs (tRNAs), represent a class of non-coding RNAs characterized by high evolutionary conservation, structural stability, and functional diversity.
DE Xiaomeng
doaj   +1 more source

The RNA Methyltransferase Dnmt2 Is Required for Efficient Dicer-2-Dependent siRNA Pathway Activity in Drosophila

Cell Reports, 2013
Transfer RNA (tRNA) fragmentation in response to stress conditions has been described in many organisms. tRNA fragments have been found in association with small interfering RNA (siRNA) components, but the biological role of these interactions remains ...
Zeljko Durdevic, Mehrpouya Balaghy Mobin, Katharina Hanna, Frank Lyko, Matthias Schaefer   +4 more
doaj   +1 more source

Transfer RNA-derived fragments as novel biomarkers of the onset and progression of gastric cancer

Experimental Biology and Medicine, 2023
Gastric cancer (GC) is a particularly malignant disease; thus, early diagnosis and treatment are especially important. Transfer RNA-derived small RNAs (tsRNAs) have been implicated in the onset and progression of various cancers. Therefore, the aim of this study was to explore the role of tRF-18-79MP9P04 (previously named tRF-5026a) in the onset and ...
Yaoyao Xie, Shuangshuang Zhang, Xiuchong Yu, Guoliang Ye, Junming Guo   +4 more
openaire   +2 more sources

Host tRNA-Derived RNAs Target the 3′Untranslated Region of SARS-CoV-2

Pathogens, 2022
The COVID-19 pandemic revealed a need for new understanding of the mechanisms regulating host–pathogen interactions during viral infection. Transfer RNA-derived RNAs (tDRs), previously called transfer RNA fragments (tRFs), have recently emerged as ...
Emily N. Hendrickson, Marna E. Ericson, Lynne T. Bemis   +2 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Small RNA populations revealed by blocking rRNA fragments in Drosophila melanogaster reproductive tissues. [PDF]

PLoS ONE, 2018
RNA interference (RNAi) is a complex and highly conserved regulatory mechanism mediated via small RNAs (sRNAs). Recent technical advances in high throughput sequencing have enabled an increasingly detailed analysis of sRNA abundances and profiles in ...
Emily K Fowler, Irina Mohorianu, Damian T Smith, Tamas Dalmay, Tracey Chapman   +4 more
doaj   +1 more source