Results 71 to 80 of about 32,286 (313)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Special rays and structures in general optical systems: generalized magnifications associated with the fundamental properties

African Vision and Eye Health, 2010
In aprevious study special rays and structures, including nodal, principal and focal rays and structures, were defined in terms of generalized magnification of reduced inclination of rays across thesystem.  The mathematical structure of the transference,
W. F. Harris
doaj   +1 more source

Transference for the Erd\H{o}s-Ko-Rado theorem [PDF]

, 2016
József Balogh, Béla Bollobás, Bhargav Narayanan   +2 more
openalex   +1 more source

The transference of family law to the Farore Islands and the inter-territorial conflicts of laws in the Kingdom of Denmark: an appraisal

, 2023
José María Lorenzo Villaverde
openalex   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Cultural Transfer and Etymology

Слово.ру: балтийский акцент, 2017
This article considers the synthesis of information transference in space and time and examines the etymology of Indo-European lexis. The author pays attention to the origin of the lexis connected with the ‘bear’ semantics.
Proskurin S.
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Artificial intelligence and psychoanalysis: is it time for psychoanalyst.AI?

Frontiers in Psychiatry
The current development of artificial intelligences (AI) is leading to major transformations within society. In this context, we observe how some of these AIs are spontaneously used by individuals as confidants, and even as romantic partners.
Thomas Rabeyron
doaj   +1 more source

Siegfried Kracauer and Walter Benjamin. Precursors of the Frankfurt School in Transference with the Slavic Body of Thought [PDF]

, 2022
Michał Mrugalski
openalex   +1 more source