Results 71 to 80 of about 172,724 (339)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

When the Unconscious Joins the Game: A Psychoanalytic Perspective on Modernization and Change

open access: yesForum: Qualitative Social Research, 2003
The article presents a psychoanalytic and cultural perspective on the modernization of the welfare state in a Danish context. The article analyzes the processes of change and development in public welfare organizations through theoretical and empirical ...
Linda Lundgaard Andersen
doaj  

Features of the Language Personality of Transnistria in the Context of Ethno Cultural and Interlingual Interaction of Russian and Moldovan Languages

open access: yesЭтническая культура, 2019
The article continues the theme of peculiarities of linguistic personality in the light of ethno-cultural interaction in the polylinguistic Pridnestrovian region.
Natalya V. Krivoshapova
doaj   +1 more source

Il Simposio di Platone letto da Jacques Lacan: ἔρως, κύκλος, ἐραστής, ἄγαλμα

open access: yesAnnali Online dell'Università di Ferrara. Sezione Lettere, 2022
Lacan’s VIII Seminar is about the transference in the analytic cure considered through the Plato’s Symposium and its commentary by Léon Robin (1929). This paper outlines some of the major points of this extensive and innovative commentary on the Plato’s ...
Raffaela Cantore
doaj   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

open access: yesFEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom   +3 more
wiley   +1 more source

Transfer and Therapeutic Endpoints Psychodynamic in Brief

open access: yesPsicologia, 2009
This research aims to verify if there is relationship between the therapeutic outcome and the transference moments that have occurred over the processes of psychotherapy shortly analyzed.
Claudia Bonfily Pimentel   +1 more
doaj  

Vídeos musicales en el aula de inglés de primaria para la mejora de la fluidez lectora / Music videos in primary English class for the improvement of reading fluency

open access: yesTejuelo: Didáctica de la Lengua y la Literatura, 2018
Resumen: La lectura es una destreza crucial que afecta el rendimiento académico en muchas materias escolares. Los resultados de las pruebas nacionales e internacionales muestran que la competencia lectora de los españoles aún requiere más atención para ...
Carmen María Toscano-Fuentes   +1 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

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