Results 1 to 10 of about 165,649 (342)

Regulation of cell surface transferrin receptor-2 by iron-dependent cleavage and release of a soluble form

Haematologica, 2015
Transferrin receptor-2 is a transmembrane protein whose expression is restricted to hepatocytes and erythroid cells. Transferrin receptor-2 has a regulatory function in iron homeostasis, since its inactivation causes systemic iron overload.
Alessia Pagani, Maud Vieillevoye, Antonella Nai, Marco Rausa, Meriem Ladli, Catherine Lacombe, Patrick Mayeux, Frédérique Verdier, Clara Camaschella, Laura Silvestri   +9 more
doaj   +2 more sources

Brain targeted delivery of rapamycin using transferrin decorated nanostructured lipid carriers [PDF]

BioImpacts, 2022
Introduction: Recent studies showed that rapamycin, as a mammalian target of rapamycin (mTOR) inhibitor, could have beneficial therapeutic effects for the central nervous system (CNS) related diseases.
Fatemeh Khonsari, Mostafa Heydari, Rassoul Dinarvand, Mohammad Sharifzadeh, Fatemeh Atyabi   +4 more
doaj   +1 more source

Extraintestinal pathogenic Escherichia coli utilizes the surface-expressed elongation factor Tu to bind and acquire iron from holo-transferrin

Virulence, 2022
Extraintestinal pathogenic Escherichia coli (ExPEC) is a common anthropozoonotic pathogen that causes systemic infections. To establish infection, ExPEC must utilize essential nutrients including iron from the host.
Yu Sun, Xuhang Wang, Jin Li, Feng Xue, Fang Tang, Jianjun Dai   +5 more
doaj   +1 more source

Serum Soluble Transferrin Receptor and Transferrin Levels among Regular Blood Donors

SciMedicine Journal, 2022
Background: The study evaluated the effects of regular blood donation on serum transferrin and soluble transferrin receptor levels at Wenchi Methodist Hospital.
Samuel K. Appiah, Simon B. Bani, Charles Nkansah, Kofi Mensah, Gabriel Abbam, Felix Osei-Boakye, Samira Daud, Charles A. Derigubah, Christopher Nkrumah, Dorcas Serwaa, Vincent Kawuribi, Deborah E. Nkansah, Benjamin O. Opoku, Catherine A. Avero, Yeduah Quansah, Candy A. E. Wilson, Felix E. Chukwurah   +16 more
doaj   +1 more source

Hepatic Transferrin Plays a Role in Systemic Iron Homeostasis and Liver Ferroptosis.

Blood, 2020
Although the serum-abundant metal-binding protein transferrin (encoded by the Trf gene) is synthesized primarily in the liver, its function in the liver is largely unknown.
Yingying Yu, Li Jiang, Hao Wang, Zhe Shen, Qi Cheng, Pan Zhang, Jiaming Wang, Qian Wu, X. Fang, Lingyan Duan, Shufen Wang, Kai Wang, P. An, Tuo Shao, R. Chung, Shusen Zheng, J. Min, Fudi Wang   +17 more
semanticscholar   +1 more source

Association between systemic iron status and β-cell function and insulin sensitivity in patients with newly diagnosed type 2 diabetes

Frontiers in Endocrinology, 2023
ObjectiveAbnormal iron metabolism is related to the risk of diabetes, but the underlying mechanism of this association remains uncertain. This study was conducted to evaluate the contributions of systemic iron status to β-cell function and insulin ...
Yao Qin, Yiting Huang, Yuxiao Li, Lu Qin, Qianying Wei, Xin Chen, Chuanhui Yang, Mei Zhang   +7 more
doaj   +1 more source

Iron sequestration by transferrin 1 mediates nutritional immunity in Drosophila melanogaster

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Hosts sequester iron as a strategy to limit pathogen acquisition of this essential nutrient in a process termed nutritional immunity. Due to their in vitro antimicrobial activity, iron-binding proteins transferrins are suspected to play a ...
I. Iatsenko, A. Marra, Jean‐Philippe Boquete, J. Peña, B. Lemaître   +4 more
semanticscholar   +1 more source

Transferrin Insufficiency and Iron Overload in Follicular Fluid Contribute to Oocyte Dysmaturity in Infertile Women With Advanced Endometriosis

Frontiers in Endocrinology, 2020
Purpose: To screen out specific protein with different concentration in follicular fluid from advanced endometriosis and determine its direct effect on mouse oocytes matured in vitro.Methods: FF samples were obtained from 25 patients (EMS group, n = 15 ...
Anji Li, Zhexin Ni, Jie Zhang, Zailong Cai, Yanping Kuang, Chaoqin Yu   +5 more
doaj   +1 more source

Variation of the serum N‐glycosylation during the pregnancy of a MPI‐CDG patient

JIMD Reports, 2021
For the first time the glycosylation of a patient with a MPI‐CDG during pregnancy is monitored. MPI‐CDG, is characterised by a deficiency in mannose‐6‐phosphate isomerase (MPI) leading to a reduced pool of glycosylation precursors, impairing the ...
Elodie Lebredonchel, Sandrine Duvet, Claire Douillard, François Foulquier, André Klein   +4 more
doaj   +1 more source

Stealthy microbes: How Neisseria gonorrhoeae hijacks bulwarked iron during infection

Frontiers in Cellular and Infection Microbiology, 2022
Transition metals are essential for metalloprotein function among all domains of life. Humans utilize nutritional immunity to limit bacterial infections, employing metalloproteins such as hemoglobin, transferrin, and lactoferrin across a variety of ...
Julie Lynn Stoudenmire, Ashley Nicole Greenawalt, Cynthia Nau Cornelissen   +2 more
doaj   +1 more source