Results 91 to 100 of about 137,943 (306)

A dual brain-targeting curcumin-loaded polymersomes ameliorated cognitive dysfunction in intrahippocampal amyloid-β1–42-injected mice

International Journal of Nanomedicine, 2016
Tingting Jia,1,* Zhiguo Sun,1,* Ying Lu,1 Jie Gao,1 Hao Zou,1 Fangyuan Xie,2 Guoqing Zhang,2 Hao Xu,3 Duxin Sun,3 Yuan Yu,1 Yanqiang Zhong1 1Department of Pharmaceutical Sciences, School of Pharmacy, The Second Military Medical University, 2Department ...
Jia TT, Sun ZG, Lu Y, Gao J, Zou H, Xie FY, Zhang GQ, Xu H, Sun DX, Yu Y, Zhong YQ   +10 more
doaj  

"In vitro" and "in vivo" drug targeting using biotinylated immunoliposomes [PDF]

, 2005
The aim of my thesis was the optimization, characterization and application of a new, innovative drug carrier system which can be used to target pharmaceuticals to diseased tissues and organs.
Schnyder, Anita
core   +1 more source

LC3B Mediated SETDB1‐Accounted Alcoholic Steatohepatitis via Lipidation‐Dependent LAP and Lipidation‐Independent Nuclear Stabilization

Advanced Science, EarlyView.
SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang, Tan Wei, Jiahang Wu, Chuixu Lin, Dongbo Zhu, Yanhui Li, Shuting Shi, Shishun Huang, Leiming Jiang, Hongzhi Wang, Meiqi Song, Pengfei Gao, Xu Wu, Mingjian Fan, Chaofeng Wei, Qian Wang, Lihui Qu, Zhigang Wang   +17 more
wiley   +1 more source

Evaluation of salivary transferrin in patients with oral squamous cell carcinoma

Clinical and Experimental Dental Research
Objectives About 94% of oral cancers are squamous cell carcinomas (OSCCs). Its occurrence is age‐related due to some factors. Salivary biomarkers have good susceptibility to OSCC's early diagnosis.
Fatemeh Tavakoli, Mohammad Ali Ghavimi, Vahid Fakhrzadeh, Dorna Abdolzadeh, Aylar Afshari, Hosein Eslami   +5 more
doaj   +1 more source

Host iron binding proteins acting as niche indicators for Neisseria meningitidis

, 2009
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited - Copyright ...
Philip W Jordan, Jordan, Philip W., Philip W. Jordan, Jordan Philip W., Saunders Nigel J., Jordan, PW, Saunders, Nigel, Saunders, NJ, Nigel J Saunders, Saunders, Nigel J., Nigel J. Saunders   +10 more
core   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

A 3D In Vitro Model of the Human Hepatobiliary Junction

Advanced Science, EarlyView.
A 3D human organoid platform reconstructs the hepatobiliary junction between primary adult hepatocytes and intrahepatic cholangiocytes. These adult hepatobiliary organoids (aHBOs) support directional bile transport from canaliculi to ductule‐like structures, enable quantitative imaging of junction dynamics, and reveal cell‐type‐specific vulnerabilities
Ashley D. Westerfield, Katarzyna A. Grzelak, Katie Katsuyama, Vardhman Kumar, Bess M. Miller, Joa Yun, Jesse Kirkpatrick, David Mankus, Margaret E. Bisher, Abigail K.R. Lytton‐Jean, Z. Gordon Jiang, David D. Lee, Christopher S. Chen, Sangeeta N. Bhatia   +13 more
wiley   +1 more source

Association of body iron stores and anemia in a Ghanaian type‐2 diabetes mellitus population: A multicentered cross‐sectional study

Health Science Reports
Background and Aims Anemia has been a common comorbidity in most chronic diseases, but has not been well monitored in type 2 diabetes mellitus (T2DM) patients.
Wina I. O. Boadu, William K. B. A Owiredu, Emmanuel Timmy Donkoh, Kwame O. Boadu, Afia A. Kwayie, Joseph Frimpong, Enoch O. Anto, Christian Obirikorang, Emmanuel E. Korsah, Ezekiel Ansah, Michael Nyantakyi, Stephen Opoku, Ebenezer Senu, Elizabeth Aboagye   +13 more
doaj   +1 more source

Regulation of cell surface transferrin receptor-2 by iron-dependent cleavage and release of a soluble form

Haematologica, 2015
Transferrin receptor-2 is a transmembrane protein whose expression is restricted to hepatocytes and erythroid cells. Transferrin receptor-2 has a regulatory function in iron homeostasis, since its inactivation causes systemic iron overload.
Alessia Pagani, Maud Vieillevoye, Antonella Nai, Marco Rausa, Meriem Ladli, Catherine Lacombe, Patrick Mayeux, Frédérique Verdier, Clara Camaschella, Laura Silvestri   +9 more
doaj   +1 more source

Neoplastic transformation of rat liver epithelial cells is enhanced by non-transferrin-bound iron-5

, 2011
concentrations were: none (open bars), 50 μM (light stipled bars), 100 μM (medium stipled bars), 200 μM (dark stipled bars), and 500 μM (solid bars). . . Triplicate wells were harvested and counted after 3 days or after 7 days (with one renewal of FAC in
Donald J Messner (82604), Kris V Kowdley (82605)   +1 more
core   +1 more source