Results 181 to 190 of about 137,943 (306)

Prognostic significance of serum iron panel in breast carcinoma: correlation with histopathological grading and molecular immunophenotypes. [PDF]

Discov Oncol
Anjankar AP, Dhok A, Basheeruddin M, Qausain S, Shukla S, Choudhary N, Ingole RP.   +6 more
europepmc   +1 more source

Infusion rate adjustment in enzyme replacement therapy with pabinafusp alfa for mucopolysaccharidosis II

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Enzyme replacement therapy (ERT) for mucopolysaccharidosis II (MPS II) requires long‐term, weekly intravenous infusions often lasting over 3 h each time, which can burden paediatric patients and caregivers and negatively affect their quality of life and treatment compliance.
Kimitoshi Nakamura, Norio Sakai, Hideaki Hirai, Naoko Takasao, Ryo Ibaraki, Tatsuyoshi Yamamoto, Yuji Sato   +6 more
wiley   +1 more source

Ferritin and transferrin predict common carotid intima-media thickness in females: a machine-learning informed individual participant data meta-analysis. [PDF]

BMC Cardiovasc Disord
Ruban Agarvas A, Sparla R, Atkins JL, Altamura C, Anderson T, Asicioglu E, Bassols J, López-Bermejo A, Dvořáková HM, Fernández-Real JM, Hochmayr C, Knoflach M, Milicevic JK, Lai S, Moreno-Navarrete JM, Pawlak D, Pawlak K, Syrovatka P, Formanowicz D, Kraml P, Valdivielso JM, Valenti L, Muckenthaler MU.   +22 more
europepmc   +1 more source

Engineering Murine Cross‐Reactivity Into an Affibody to Human Death Receptor 5

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Interspecies cross‐reactive protein therapeutics that target conserved epitopes across species are critical for translational research. The present study showcases the engineering of an affibody molecule, originally discovered for binding to human death receptor 5 (hDR5) with 94 nM affinity, to simultaneously acquire cross‐reactivity to murine
Tse‐Han Kuo, Nagamani Vunnam, Jonathan N. Sachs, Benjamin J. Hackel   +3 more
wiley   +1 more source

Proteomics to reveal relationship between menstrual cycle and subjective conditions. [PDF]

Sci Rep
Fushimi K, Kondo T, Ikegami N, Yamada M, Wong SY, Sakamaki-Sunaga M, Hayashi N.   +6 more
europepmc   +1 more source

Designing the MyoFusion Media: A Serum‐Free Medium Optimized for Bovine Satellite Cell Differentiation

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Cultivated meat production requires efficient differentiation of muscle progenitor cells into myotubes without relying on animal‐derived serum, which poses ethical and scalability challenges. This study aimed to develop a chemically defined, serum‐free medium optimized for bovine satellite cell differentiation.
Aysenaz Tavsanli, Viktor Milkevych, Jette Feveile Young, Martin Krøyer Rasmussen   +3 more
wiley   +1 more source

Biomarkers of iron deficiency and prognosis in patients hospitalised with new-onset heart failure and a reduced left ventricular ejection fraction. [PDF]

Open Heart
Johansson JSM, Henrysson J, Basic C, Cleland JGF, Fu M, Ljungman C.   +5 more
europepmc   +1 more source

Discovery of CRBN‐based molecular glue degraders targeting WIZ transcription factor

Bulletin of the Korean Chemical Society, EarlyView.
This work reports the discovery of 9l, a novel cereblon‐based molecular glue degrader which targets the WIZ transcription factor. Compound 9l facilitates WIZ‐CRBN ternary complex formation to degrade WIZ, subsequently inducing γ‐globin expression in HUDEP‐2 cells and highlighting its potential as a sickle cell disease therapy.
Tae‐Jun Kim, Seongu Seong, Jung‐Ae Kim, Taeyeon Kwon, Hyun Jin Kim, Jeong‐Hoon Kim, Jong Yeon Hwang, Jin Hwa Cho, Kyoungmin Choi   +8 more
wiley   +1 more source

Biomarker-Defined Iron Deficiency in Heavy Smokers with and without COPD and/or Emphysema. [PDF]

Int J Chron Obstruct Pulmon Dis
Hardang IM, Neumann K, Gjønnes GT, Strand TE, Ashraf H, Einvik G.   +5 more
europepmc   +1 more source

Transferrin receptor expression is controlled differently by transferrin-bound and non-transferrin iron in human cells

We studied the effects of iron supplied as transferrin-bound iron and iron supplied as non-transferrin iron on transferrin receptor expression by human cell lines.
Chiba, P., Kriegerbeckova, K., Kovar, J., Kühn, L. C., Goldenberg, H., Richardson, V., Dopper-Brunner, L.   +6 more
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