Results 321 to 330 of about 212,698 (347)

Transferrin toxin but not transferrin receptor immunotoxin is influenced by free transferrin and iron saturation

European Journal of Clinical Investigation, 2002
AbstractBackground  Cytotoxic agents can be targeted successfully to cancer cells. The efficacy of such novel and potent anticancer strategies may be influenced by variables of iron metabolism.Methods  The in vitro cytotoxicity against glioma cells of transferrin (Tf)‐based targeted toxins was compared with that of α‐transferrin receptor (TfR ...
A J G van-Dijk, G C de-Gast, Andrea Bolognesi, H G J Krouwer, W C Vooijs, Joannes J.M. Marx, P H Gosselaar, Letizia Polito, A F M Verheul   +8 more
openaire   +2 more sources

CSF transferrins characterized by the transferrin/albumin index

Clinica Chimica Acta, 1980
Unconcentrated CSF and 200 times diluted serum samples from 192 patients were examined by agar electrophoresis; their albumin and transferrin content were determined simultaneously by radial immunodiffusion. Using the data on transferrin and albumin concentrations in serum and cerebrospinal fluid, the transferrin/albumin index was calculated in a ...
L. Kerényi, I. Szirmai, Mária Koltai
openaire   +3 more sources

ChemInform Abstract: Transferrin/Transferrin Receptor‐Mediated Drug Delivery

ChemInform, 2002
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Hongyan Li, Zhong Ming Qian
openaire   +3 more sources

Iron, transferrin and myelinogenesis

Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2003
Abstract Transferrin (Tf), the iron binding protein of vertebrates serum, is known to be synthesized by oligodendrocytes (Ols) in the central nervous system. It has been postulated that Tf is involved in Ols maturation and myelinogenesis. This link is particularly important in the understanding of a severe human pathology: the multiple sclerosis ...
Sergeant, Claire, Vesvres, Marie-Hélène, Devès, Guillaume, Baron, Bruno, Guillou, Florian   +4 more
openaire   +4 more sources

The role of transferrin in atherosclerosis

Medical Hypotheses, 2008
Transferrin is a plasma protein with the primary role of transporting iron through the body and delivering it to the cells that utilize it. Because free ionic iron is very toxic by creating free radicals, the importance of transferrin lies in its antioxidant properties.
Tatjana Belovari, Aleksandar Kibel, Ines Drenjančević-Perić   +2 more
openaire   +4 more sources

Immunostaining of transferrin and transferrin receptor in human seminiferous tubules

Fertility and Sterility, 1986
Transferrin (TF) and transferrin receptor (TFr) were studied in human testicular biopsy specimens with the use of immunostaining techniques. A polyclonal antibody to human TF (obtained in goat), a murine monoclonal antibody (B3/25) to human TFr, and antisera antigoat IgG and antimouse IgG, both labeled with peroxidase, were used.
VANNELLI, GABRIELLA, ORLANDO, CLAUDIO, BARNI, TULLIO, NATALI, ALESSANDRO, SERIO, MARIO, BALBONI, GIUSEPPE CARLO   +5 more
openaire   +4 more sources

Transferrin subtypes in Iran

Anthropologischer Anzeiger, 1990
The frequency of transferrin Tf C subtypes has been determined by double one-dimensional electrophoresis of plasma samples from Moslems (n = 91), Zoroastrians (n = 97), Jews (n = 88) and Armenians (n = 88) of Iran. The Zoroastrians show the lowest frequency of TfC1 (0.4999) and highest frequencies of TfC2 and TfC3 (.02215, and 0.2783, respectively ...
D D Farhud, P Daneshmand, R Hackler, M Saffari, K Altland   +4 more
openaire   +2 more sources

Transferrin receptor 2 mediates uptake of transferrin-bound and non-transferrin-bound iron

Journal of Hepatology, 2008
Transferrin receptor 2 appears to have dual roles in iron metabolism; one is signalling, the other is iron transport. It is sensitive to high levels of diferric transferrin, which is associated with disorders of iron overload. Also present in these disorders are increased levels of plasma non-transferrin-bound iron.
Ross M. Graham, Carly E. Herbison, John K. Olynyk, John K. Olynyk, Debbie Trinder, Debbie Trinder, Gail M. Reutens, Anita C. G. Chua, Roheeth D. Delima   +8 more
openaire   +4 more sources

Targeting with Transferrin [PDF]

, 2002
Transferrin, (trf) a serum glycoprotein (molecular weight 80,000) has been of interest to several investigators due to the high efficacy of its endocytosis via transferrin receptors. Its basic role in the body is to facilitate the transport of iron into cells.
openaire   +1 more source

An immunoassay for human transferrin

The American Journal of Clinical Nutrition, 1988
The laboratory measurement of serum transferrin is a valuable adjunct in the assessment of both iron and protein nutritional status. Conventional assays based on the Fe-binding properties of this protein are tedious to perform, susceptible to Fe contamination, and require volumes of serum that can only be obtained by venous sampling.
A M Covell, M el Guindi, Barry S. Skikne, James D. Cook   +3 more
openaire   +3 more sources