Results 261 to 270 of about 2,476,356 (396)

Biogenesis of Organelles and Membrane Proteins. [PDF]

open access: yes, 1988
Harmey, Matthew A.   +3 more
core   +1 more source

Ligand‐Driven Optimization of Iron Oxide Nanoprobes for In Vivo MRI Enhancement at Ultra‐High Field

open access: yesSmall, EarlyView.
Ligand‐tailored iron oxide nanoparticles reveal how surface chemistry controls T2 relaxivity and in vivo performance in ultra‐high‐field MRI. Systematic variation of hydrophilicity and charge across five coatings modulated r2 by up to 333 mm−1 s−1, with chemical properties, rather than shell thickness, dictating magnetic dephasing and enabling reliable
Pelayo García‐Acevedo   +6 more
wiley   +1 more source

Lethal Cardiomyopathy in Mice Lacking Transferrin Receptor in the Heart.

open access: yesCell Reports, 2015
Wenjing Xu   +5 more
semanticscholar   +1 more source

Organelle Sorting and Proteomic Analysis to Identify Proteins Involved in the Uptake and Intracellular Trafficking of Nanoparticles

open access: yesSmall Methods, EarlyView.
A new method to identify proteins involved in the uptake and intracellular trafficking of nanoparticles is presented. After nanoparticle uptake, cells are lysed and the organelles with nanoparticles are purified using fluorescence assisted cell sorting. Next, their composition is determined by proteomic analysis.
Hector Garcia Romeu, Anna Salvati
wiley   +1 more source

Transferrin receptor-binding blood-brain barrier shuttle enhances brain delivery and plaque-clearing efficacy of a therapeutic anti-Aβ antibody. [PDF]

open access: yesFluids Barriers CNS
Vega MR   +12 more
europepmc   +1 more source

Brain Pericytes and Wnt/β‐Catenin Signaling Induce Functional Blood–Brain Barrier Phenotype in Human iPSC‐Derived Model

open access: yesSmall Methods, EarlyView.
This study shows that human iPSC‐derived endothelial cells acquire a functional blood–brain barrier phenotype when co‐cultured with brain pericytes and stimulated with CHIR‐99021, a Wnt/β‐catenin activator. This model recapitulates key barrier properties, inflammatory responses, and transcriptomic features of the native human BBB, offering new ...
Henrique Nogueira Pinto   +12 more
wiley   +1 more source

A pH-sensitive binding modality allows successful transferrin receptor-mediated transcytosis of a bivalent antibody across brain barriers. [PDF]

open access: yesMAbs
Kuhn P   +14 more
europepmc   +1 more source

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