Results 71 to 80 of about 2,476,356 (396)

Orchestrated regulation of iron trafficking proteins in the kidney during iron overload facilitates systemic iron retention. [PDF]

PLoS ONE, 2018
The exact route of iron through the kidney and its regulation during iron overload are not completely elucidated. Under physiologic conditions, non-transferrin and transferrin bound iron passes the glomerular filter and is reabsorbed through kidney ...
Avital Weiss, Lior Spektor, Lyora A Cohen, Lena Lifshitz, Inbar Magid Gold, De-Liang Zhang, Marianna Truman-Rosentsvit, Yael Leichtmann-Bardoogo, Abraham Nyska, Sefi Addadi, Tracey A Rouault, Esther G Meyron-Holtz   +11 more
doaj   +1 more source

Transferrin receptor expression and the regulation of placental iron uptake [PDF]

, 1991
Placental transferrin receptors, located at the apical side of syncytiotrophoblast, mediate placental iron uptake. Regulation of transferrin receptors on the fetal-maternal exchange area could be a major determinant in the regulation of trans-placental ...
Baert, M.R.M. (Miranda), Bierings, M. (Marc), Dijk, J.P. (Johannes) van, Eijk, H.G. (Henk) van   +3 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Targeting transferrin receptor delivery of temozolomide for a potential glioma stem cell-mediated therapy

OncoTarget, 2017
Glioma stem cells, which are sub-populations of tumor cells, are responsible for resistant responses to radiotherapy and chemotherapy after surgery.
T. Sun, Haibin Wu, Yanyan Li, Yulun Huang, Lin Yao, Xiong-hui Chen, Xiaoxiao Han, Youxin Zhou, Z. Du   +8 more
semanticscholar   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Exploring Patients’ Profiles Associated With the Resolution of Acute Calcium Pyrophosphate Arthritis Treated With Colchicine and Prednisone: Post Hoc Analysis of a Randomized Controlled Trial

Arthritis Care &Research, EarlyView.
Objective The objective was to identify factors determining acute arthritis resolution and safety with colchicine and prednisone in acute calcium pyrophosphate (CPP) crystal arthritis. Methods We conducted a post hoc analysis of the COLCHICORT trial, which compared colchicine and prednisone for the treatment of acute CPP crystal arthritis, using a ...
Tristan Pascart, Laurène Norberciak, Pascal Richette, Pierre Robinet, Aurore Pacaud, Gauthier Marchasson, Thibault Rabin, Hélène Luraschi, Pierre Maciejasz, Anne‐France Georgel, Augustin Latourte, Hang‐Korng Ea, Sébastien Ottaviani, Charlotte Jauffret, Vincent Ducoulombier   +14 more
wiley   +1 more source

Soluble transferrin receptor and immature reticulocytes are not useful for distinguishing iron-deficiency anemia from heterozygous beta-thalassemia

São Paulo Medical Journal
Iron deficiency and heterozygous beta-thalassemia are important causes of hypochromic-microcytic anemia. Two laboratory parameters are suggested for the differentiation of such anemia.
Gisélia Aparecida Freire Maia de Lima, Helena Zerlotti Wolf Grotto   +1 more
doaj   +1 more source

Iron metabolism and its association with dyslipidemia risk in children and adolescents: a cross-sectional study

Lipids in Health and Disease, 2019
Background Information on the association between iron metabolism and dyslipidaemia in children is limited. Thus, this study aims to evaluate the iron metabolic status of children with different body mass index (BMI) and to examine the association ...
Yanna Zhu, Baoting He, Yunjun Xiao, Yajun Chen   +3 more
doaj   +1 more source

Kinetics of Blood–Brain Barrier Transport of Monoclonal Antibodies Targeting the Insulin Receptor and the Transferrin Receptor

Pharmaceuticals, 2021
Biologic drugs are large molecule pharmaceuticals that do not cross the blood–brain barrier (BBB), which is formed by the brain capillary endothelium.
William M. Pardridge
doaj   +1 more source

Role of transferrin, transferrin receptors, and iron in macrophage listericidal activity. [PDF]

, 1991
It is not yet known what properties distinguish macrophages which can kill facultative intracellular bacteria, such as Listeria monocytogenes, from those which cannot.
Alford, CE, Campbell, PA, King, TE
core