Results 101 to 110 of about 1,026,560 (278)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Current status and trends of wheat genetic transformation studies in China
Journal of Integrative Agriculture, 2015 More than 20 years have passed since the first report on successful genetic transformation of wheat. With the establishment and improvement of transformation platform, great progresses have been made on wheat genetic transformation both on its ...
Yi HE +5 more
doaj +1 more source
Genetic Transformation in Proteus mirabilis [PDF]
Journal of General Microbiology, 1971 SUMMARY: A method is described for the isolation of biologically active DNA from Proteus mirabilis strain 13 which could transform auxotrophic mutants of P. mirabilis to prototrophy. This DNA preparation did not transform similar mutants of P. vulgaris.
openaire +2 more sources
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Genetic Transformation of Recalcitrant Cassava by Embryo Selection and Increased Hormone Levels
Methods and Protocols, 2018 Genetic engineering is considered to be an important tool for the improvement of cassava. Cassava is a highly heterozygous crop species for which conventional breeding is a lengthy and tedious process.
Ezequiel Matías Lentz +6 more
doaj +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Exploring Agrobacterium-mediated genetic transformation methods and its applications in Lilium
Plant MethodsAs a typical bulb flower, lily is widely cultivated worldwide because of its high ornamental, medicinal and edible value. Although breeding efforts evolved over the last 10000 years, there are still many problems in the face of increasing consumer demand.
Xinyue Fan, Hongmei Sun
doaj +1 more source
CONSUMER ACCEPTANCE OF GMO COWPEAS IN SUB-SAHARA AFRICA [PDF]
Cowpea is the most important indigenous African grain legume for both home use and as a cash crop. Because of its tolerance to drought it is especially important for the Sahel.
Fulton, Joan R. +3 more
core +1 more source
Functional analysis of CcDREB1D promoter region from haplotypes of Coffea canephora through genetic transformation of Nicotiana tabacum [PDF]
, 2014 Recent studies in coffee resulted in the identification of many candidate genes for drought tolerance characterized by differential expression profiles in leaves of drought-tolerant and susceptible clones of Coffea canephora Conilon.
Alves, Gabriel Sergio Costa +6 more
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