Results 41 to 50 of about 1,327,857 (249)

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Correlation between the triglyceride-glucose index and left ventricular global longitudinal strain in patients with chronic heart failure: a cross-sectional study

Cardiovascular Diabetology
Background Left ventricular global longitudinal strain (GLS) holds greater diagnostic and prognostic value than left ventricular ejection fraction (LVEF) in the heart failure (HF) patients.
Shuai Zhang, Yan Liu, Fangfang Liu, Qing Ye, Dachuan Guo, Panpan Xu, Tianhao Wei, Cheng Zhang, Huixia Lu   +8 more
doaj   +1 more source

Transforming vaccinology

Cell
The COVID-19 pandemic placed the field of vaccinology squarely at the center of global consciousness, emphasizing the vital role of vaccines as transformative public health tools. The impact of vaccines was recently acknowledged by the award of the 2023 Nobel Prize in Physiology or Medicine to Katalin Kariko and Drew Weissman for their seminal ...
Rino Rappuoli, Galit Alter, Bali Pulendran   +2 more
openaire   +3 more sources

Appell Transformation and Canonical Transforms [PDF]

Symmetry, Integrability and Geometry: Methods and Applications, 2011
The interpretation of the optical Appell transformation, as previously elaborated in relation to the free-space paraxial propagation under both a rectangular and a circular cylindrical symmetry, is reviewed. Then, the caloric Appell transformation, well known in the theory of heat equation, is shown to be amenable for a similar interpretation involving
openaire   +5 more sources

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Dual-Sliding-Mode-Observer-Based IPMSM Sensorless Control Technique

Complexity
Back electromotive force (EMF)-based sliding mode observer (SMO) is increasingly employed for interior permanent magnet synchronous machine (IPMSM) sensorless drives due to its high robustness to external disturbance and low sensitivity to system ...
Sang Xu, Anwen Shen, Mingzhen Zhang, Qipeng Tang, Xin Luo, Jinbang Xu   +5 more
doaj   +1 more source

Addressing racial disparities in perinatal care for African American/Black individuals in the Chicago community health setting: a qualitative study

BMC Pregnancy and Childbirth, 2022
Background There are persistent disparities in maternal and infant perinatal outcomes experienced by Black birthing persons compared with non-Hispanic white (NHW) individuals in the US.
Jonathan Alhalel, Lane Patterson, Nicolás O. Francone, Sankirtana Danner, Cassandra Osei, Catherine Ann O’Brian, Laura S. Tom, Lisa Masinter, Elizabeth Adetoro, Danielle Lazar, Abbey Ekong, Melissa A. Simon   +11 more
doaj   +1 more source