Results 61 to 70 of about 3,035,887 (300)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Challenges for remote patient monitoring programs in rural and regional areas: a qualitative study

BMC Health Services Research
Background Access to healthcare significantly influences health outcomes, and rural, regional and remote populations face greater challenges in accessing healthcare than urban populations.
Joel Fossouo Tagne, Kara Burns, Teresa O’Brein, Wendy Chapman, Portia Cornell, Kit Huckvale, Ishaan Ameen, Jaclyn Bishop, Alison Buccheri, Jodie Reid, Anna Wong Shee, Marc Budge, Catherine E. Huggins, Anna Peeters, Olivia Metcalf   +14 more
doaj   +1 more source

Transformations Debugging Transformations.

, 2017
Abstract: Practical model transformation (MT) frameworks are usually composed of multiple execution contexts, building an overall workflow by abstracting different aspects of execution. This heterogeneity brings additional challenges to debugging, which must address a combination of quite different graphical and textual formalisms.
Jukks, Maris, Verbrugge, Clark, Vangheluwe, Hans   +2 more
openaire   +2 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Machine learning-based screening for Ascertain Dementia 8-defined suspected cognitive impairment leveraging routine health check data in South China

Journal of Alzheimer's Disease Reports
Background Timely detection of cognitive concerns can facilitate further assessment, referral, and management; however, cognitive impairment often remains under-detected in primary care settings, representing a missed opportunity for early detection for ...
Peiyue Su, Jiale Li, Yang Hu, Yue Xu, Qianqian Ji, Qi Liu, Xiaoping Huang, Ruitong Liao, Liuqing Li, Yueting Liao, Yunzhang Wang, Yifan Lin, Yiqiang Zhan   +12 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Lebensmittelverluste in der Wertschöpfungskette im Kontext der Digitalen Transformation - Eine explorative Studie zur Anwendung ausgewählter digitaler Technologien zur Verringerung von Lebensmittelverlusten innerhalb der Wertschöpfungskette

, 2021
Nachhaltigkeits-Aspekte der Ernährung, darunter auch Lebensmittelverluste, stellen einen starken Treiber für die digitale Transformation in der Land- und Ernährungswirtschaft sowie bei Verbraucher*innen dar.
Zimmermann, Birgit, Dreyer, Jana
core   +1 more source

Abdominal obesity in India: sex stratified multilevel estimates across 707 districts from a nationally representative cross-sectional survey

Scientific Reports
Abdominal obesity, measured using the waist-to-hip ratio, is an emerging public health concern in India, yet national averages mask important subnational variation relevant for local policy and prevention planning.
Pratheeba John, Rimjhim Bajpai, Sudheer Kumar Shukla, Prince Chugh, Ritesh Ranjan Pushkar, G Thavasi Murugan, Rajeev Sadanandan, Sita Rama Budaraju, Nishikant Singh   +8 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Transformation.

Genome biology, 2006
The Nobel process for science are often somewhat controversial for who they omit. A posthumous Nobel honor could help recognize some neglected heroes.
openaire   +2 more sources