Results 41 to 50 of about 1,241,486 (266)

A Single Amino Acid Switch in the Adenoviral DNA Binding Protein Abrogates Replication Center Formation and Productive Viral Infection

mBio, 2022
Adenoviruses are very efficient high-capacity vaccine vectors and are common gene delivery systems. Despite their extensive use in preclinical models and clinical trials over the past decades, adenoviral vectors still require optimization.
Jana Boddin, Wing-Hang Ip, Britta Wilkens, Konstantin von Stromberg, Wilhelm Ching, Emre Koyuncu, Luca D. Bertzbach, Thomas Dobner   +7 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Differential Regulation of Cellular FAM111B by Human Adenovirus C Type 5 E1 Oncogenes

Viruses, 2021
The adenovirus type 5 (HAdV-C5) E1 transcription unit encodes regulatory proteins that are essential for viral replication and transformation. Among these, E1A and E1B-55K act as key multifunctional HAdV-C5 proteins involved in various steps of the viral
Wing-Hang Ip, Britta Wilkens, Anastasia Solomatina, Judith Martin, Michael Melling, Paloma Hidalgo, Luca D. Bertzbach, Thomas Speiseder, Thomas Dobner   +8 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Transformations Debugging Transformations. [PDF]

, 2017
Abstract: Practical model transformation (MT) frameworks are usually composed of multiple execution contexts, building an overall workflow by abstracting different aspects of execution. This heterogeneity brings additional challenges to debugging, which must address a combination of quite different graphical and textual formalisms.
Jukks, Maris, Verbrugge, Clark, Vangheluwe, Hans   +2 more
openaire   +1 more source

Community based interventions for the primary prevention of cardiovascular disease in women living in rural, regional and remote areas: a scoping review

BMC Health Services Research
Background Cardiovascular disease (CVD) is the leading cause of death among women worldwide, yet prevention has historically centered on male risk profiles.
Madison Frith, Mary Rose Angeles, Feby Savira, Sean Randall, Crystal Man Ying Lee, Rachel Huxley, Suzanne Robinson   +6 more
doaj   +1 more source

The effectiveness of sedentary behaviour interventions on sitting time and screen time in children and adults: an umbrella review of systematic reviews

International Journal of Behavioral Nutrition and Physical Activity, 2020
Background There is increasing concern about the time people spend in sedentary behaviour, including screen time, leisure and occupational sitting. The number of both primary research studies (published trials) and reviews has been growing rapidly in ...
Phuong Nguyen, Long Khanh-Dao Le, Dieu Nguyen, Lan Gao, David W. Dunstan, Marj Moodie   +5 more
doaj   +1 more source

Global consortium on security transformation : final narrative report, 2008-2010 [PDF]

, 2010
The GCST fills the gap between citizens’ perceptions and government policies by encouraging the inclusion of new voices within policy discussions and analysis, especially those of the poor and insecure; making sure existing initiatives become more ...

core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Assessing the financial burden of multimorbidity among patients aged 30 and above in India

BMC Health Services Research
Background Multimorbidity is associated with significant out-of-pocket expenditures (OOPE) and catastrophic health expenditure (CHE), especially in low- and middle-income countries like India.
Sudheer Kumar Shukla, Pratheeba John, Sakshi Khemani, Ankur Shaji Nair, Nishikant Singh, Rajeev Sadanandan   +5 more
doaj   +1 more source