Results 41 to 50 of about 3,035,887 (300)

Other title: Office of Children Services Transformation initial findings report

, 2020
"February 2020."; "Mike DeWine, Governor of Ohio; Jon Husted, Lt. Governor of Ohio."; "Ohio Governor's Children's Initiative, Children Services Transformation."; "Safe children. Stable homes.
Ohio. Children Services Transformation Advisory Council
core  

Harnessing the potential of livestock agribusiness to address Africa’s youth bulge through decent employment and enhanced food security in a disrupted global landscape

Discover Sustainability
Africa’s youth bulge presents both a critical challenge and a transformative opportunity for sustainable development. With over 60% of the population under the age of 25 and youth unemployment averaging 33%, the continent urgently needs inclusive ...
Kefena Effa, Haile Deressa, Kassahun Teka, Amssalu Bezabeh, Negassi Ameha, Seid Mohammed, Fikru Regassa   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Community based interventions for the primary prevention of cardiovascular disease in women living in rural, regional and remote areas: a scoping review

BMC Health Services Research
Background Cardiovascular disease (CVD) is the leading cause of death among women worldwide, yet prevention has historically centered on male risk profiles.
Madison Frith, Mary Rose Angeles, Feby Savira, Sean Randall, Crystal Man Ying Lee, Rachel Huxley, Suzanne Robinson   +6 more
doaj   +1 more source

A Single Amino Acid Switch in the Adenoviral DNA Binding Protein Abrogates Replication Center Formation and Productive Viral Infection

mBio, 2022
Adenoviruses are very efficient high-capacity vaccine vectors and are common gene delivery systems. Despite their extensive use in preclinical models and clinical trials over the past decades, adenoviral vectors still require optimization.
Jana Boddin, Wing-Hang Ip, Britta Wilkens, Konstantin von Stromberg, Wilhelm Ching, Emre Koyuncu, Luca D. Bertzbach, Thomas Dobner   +7 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Training for our digital future: a human-centered design approach to graduate medical education for aspiring clinician-innovators

npj Digital Medicine, 2018
In the current era of value-based healthcare with increasing emphasis on delivering higher quality care at lower costs, US healthcare innovation as a metric is at a premium. However, an implementation gap exists between technology-enabled innovations and
Jocelyn Carter, Yanik J. Bababekov, Maulik D. Majmudar   +2 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Assessing the financial burden of multimorbidity among patients aged 30 and above in India

BMC Health Services Research
Background Multimorbidity is associated with significant out-of-pocket expenditures (OOPE) and catastrophic health expenditure (CHE), especially in low- and middle-income countries like India.
Sudheer Kumar Shukla, Pratheeba John, Sakshi Khemani, Ankur Shaji Nair, Nishikant Singh, Rajeev Sadanandan   +5 more
doaj   +1 more source