Results 91 to 100 of about 452,874 (322)

Preparation and application of a Brucella multiepitope fusion protein based on bioinformatics and Tandem Mass Tag-based proteomics technology

Frontiers in Immunology
IntroductionBrucellosis is a widespread zoonotic disease that poses a considerable challenge to global public health. Existing diagnostic methods for this condition, such as serological assays and bacterial culture, encounter difficulties due to their ...
Qi Wu, Yuan Yuan, Liping Guo, Yujia Xie, Meixue Yao, Dehui Yin, Dehui Yin, Dehui Yin, Dehui Yin   +8 more
doaj   +1 more source

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

FEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke, Nils Alexander Lakomek, Georg Groth   +2 more
wiley   +1 more source

Mechanistic Basis for Decreased Antimicrobial Susceptibility in a Clinical Isolate of Neisseria gonorrhoeae Possessing a Mosaic-Like mtr Efflux Pump Locus

mBio, 2018
Recent reports suggest that mosaic-like sequences within the mtr (multiple transferable resistance) efflux pump locus of Neisseria gonorrhoeae, likely originating from commensal Neisseria sp.
Corinne E. Rouquette-Loughlin, Jennifer L. Reimche, Jacqueline T. Balthazar, Vijaya Dhulipala, Kim M. Gernert, Ellen N. Kersh, Cau D. Pham, Kevin Pettus, A. Jeanine Abrams, David L. Trees, Sancta St Cyr, William M. Shafer   +11 more
doaj   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

APPLYING TOGAF-BASED ENTERPRISE ARCHITECTURE IN THE HEALTHCARE SECTOR: A CASE STUDY OF THE NATIONAL CENTER FOR DIABETES IN JORDAN

Jordanian Journal of Computers and Information Technology
Technology implementation can significantly benefit organizations, but ensuring it aligns with their business needs and goals is crucial. Adopting an enterprise architecture approach can aid healthcare enterprises in overcoming challenges during the ...
Hania Al Omari, Abedalrhman Alkhateeb, Bassam Hammo   +2 more
doaj   +1 more source

A review of knowledge of the potential impacts of GMOs on organic agriculture [PDF]

, 2001
The organic movement believes that organic agriculture, by its nature, cannot involve the use of genetically modified organisms (GMOs). This has been incorporated into EU regulations which state that there is no place in organic agriculture for GMOs ...
Clarke, Belinda, Dale, Phillip, Fontes, Eliana, Martin, Wolfe, Pearce, Bruce, Welsh, James   +5 more
core  

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

A backward procedure for change-point detection with applications to copy number variation detection

, 2019
Change-point detection regains much attention recently for analyzing array or sequencing data for copy number variation (CNV) detection. In such applications, the true signals are typically very short and buried in the long data sequence, which makes it ...
Hao, Ning, Shin, Seung Jun, Wu, Yichao
core   +1 more source

Novel and unscrutinized immune entities of the zebrafish gut

FEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil, Marine Mantel, Julia Soh, Serge Mostowy, Sylvia Brugman, Gilles Claude Vanwalleghem   +5 more
wiley   +1 more source

An efficient transient expression system for gene function analysis in rose

Plant Methods, 2017
Background Roses are widely used as garden ornamental plants and cut flowers. Rosa chinensis cv ‘Old Blush’ has been used as a model genotype in rose studies due to its contribution to recurrent flowering and tea scent traits of modern roses.
Jun Lu, Mengjuan Bai, Haoran Ren, Jinyi Liu, Changquan Wang   +4 more
doaj   +1 more source