Results 101 to 110 of about 2,864,901 (314)

Virus-induced gene silencing: empowering genetics in non-model organisms

Journal of Experimental Botany, 2018
Virus-induced gene silencing (VIGS) is an RNA interference-based technology used to transiently knock down target gene expression by utilizing modified plant viral genomes.
A. B. Dommes, T. Gross, D. Herbert, Kimmo I Kivivirta, A. Becker   +4 more
semanticscholar   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

The early life microbiome of giant grouper (Epinephelus lanceolatus) larvae in a commercial hatchery is influenced by microorganisms in feed

Animal Microbiome
Fish health, growth and disease is intricately linked to its associated microbiome. Understanding the influence, source and ultimately managing the microbiome, particularly for vulnerable early life-stages, has been identified as one of the key ...
Jin Yan Lim, Yun Kit Yeoh, Maximiliano Canepa, Richard Knuckey, Dean R. Jerry, David G. Bourne   +5 more
doaj   +1 more source

Universal protein fluctuations in populations of microorganisms

, 2012
The copy number of any protein fluctuates among cells in a population; characterizing and understanding these fluctuations is a fundamental problem in biophysics.
Braun, Erez, Brenner, Naama, Elyahu, Noa, Libchaber, Albert, Moore, Lindsay, Salman, Hanna, Stolovicki, Elad, Tung, Chih-kuan   +7 more
core   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Preparation and application of a Brucella multiepitope fusion protein based on bioinformatics and Tandem Mass Tag-based proteomics technology

Frontiers in Immunology
IntroductionBrucellosis is a widespread zoonotic disease that poses a considerable challenge to global public health. Existing diagnostic methods for this condition, such as serological assays and bacterial culture, encounter difficulties due to their ...
Qi Wu, Yuan Yuan, Liping Guo, Yujia Xie, Meixue Yao, Dehui Yin, Dehui Yin, Dehui Yin, Dehui Yin   +8 more
doaj   +1 more source

Mechanistic Basis for Decreased Antimicrobial Susceptibility in a Clinical Isolate of Neisseria gonorrhoeae Possessing a Mosaic-Like mtr Efflux Pump Locus

mBio, 2018
Recent reports suggest that mosaic-like sequences within the mtr (multiple transferable resistance) efflux pump locus of Neisseria gonorrhoeae, likely originating from commensal Neisseria sp.
Corinne E. Rouquette-Loughlin, Jennifer L. Reimche, Jacqueline T. Balthazar, Vijaya Dhulipala, Kim M. Gernert, Ellen N. Kersh, Cau D. Pham, Kevin Pettus, A. Jeanine Abrams, David L. Trees, Sancta St Cyr, William M. Shafer   +11 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Unraveling transformation of follicular lymphoma to diffuse large B-cell lymphoma

PLoS ONE, 2019
Follicular lymphoma (FL) is an indolent but largely incurable disease. Some patients suffer histological transformation to a more aggressive subtype with poorer prognosis.
J. González-Rincón, M. Méndez, S. Gómez, Juan F. García, Paloma Martin, C. Bellas, L. Pedrosa, S. Rodríguez-Pinilla, F. Camacho, C. Quero, D. Pérez-Callejo, A. Rueda, M. Llanos, J. Gomez-Codina, M. Piris, S. Montes-Moreno, C. Bárcena, D. Rodríguez-Abreu, J. Menárguez, Luis de la Cruz-Merino, S. Monsalvo, C. Parejo, A. Royuela, I. Kwee, L. Cascione, A. Arribas, F. Bertoni, M. Mollejo, M. Provencio, M. Sánchez-Beato   +29 more
semanticscholar   +1 more source