Results 101 to 110 of about 569,350 (369)

Unconventional mRNA processing and degradation pathways for the polycistronic yrzI (spyTA) mRNA in Bacillus subtilis

FEBS Letters, EarlyView.
The S1025 peptide is the major antidote to the YrzI toxin, which we renamed here as SpyT (Small Peptide YrzI Toxin) and SpyA (Small Peptide YrzI Antitoxin) (1). Degradation of the toxin–antitoxin spyTA mRNA, either by a translation‐dependent cleavage by the endoribonuclease Rae1 (2) or by direct attack by 3′‐exoribonucleases (3), also contributes to ...
Laetitia Gilet, Magali Leroy, Alexandre Maes, Ciarán Condon, Frédérique Braun   +4 more
wiley   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

An efficient system for Agrobacterium-mediated transient transformation in Pinus tabuliformis

Plant Methods, 2020
Background Functional genomic studies using genetics approaches of conifers are hampered by the complex and enormous genome, long vegetative growth period, and exertion in genetic transformation.
Shuangwei Liu, Jingjing Ma, Hongmei Liu, Yingtian Guo, Wei Li, Shihui Niu   +5 more
doaj   +1 more source

Genetic Algorithms for Word Problems in Partially Commutative Groups [PDF]

LNCS 4446, Springer-Verlag (2007), 48--59, 2004
We describe an implementation of a genetic algorithm on partially commutative groups and apply it to the double coset search problem on a subclass of groups. This transforms a combinatorial group theory problem to a problem of combinatorial optimisation.
arxiv  

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

Molecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever, Renske D. M. Steenbergen   +1 more
wiley   +1 more source

An Evolutionary Reduction Principle for Mutation Rates at Multiple Loci [PDF]

, 2010
A model of mutation rate evolution for multiple loci under arbitrary selection is analyzed. Results are obtained using techniques from Karlin (1982) that overcome the weak selection constraints needed for tractability in prior studies of multilocus event
A. Eyre-Walker, A. Fox, A. S. Kondrashov, A. S. Kondrashov, A. S. Kondrashov, B. Balkau, B. Charlesworth, B. Charlesworth, B. Charlesworth, C. F. Baer, C. Hoede, E. Deutsch, F. A. Kondrashov, F. Ababneh, F. Rodríguez, F. Squartini, I. M. Singer, J. F. C. Kingman, J. F. C. Kingman, J. H. Wilkinson, J. J. Duistermaat, J. Keilson, J. R. Munkres, K. E. Holsinger, K. E. Holsinger, K. Holsinger, K. V. Pylkov, L. A. Zhivotovsky, L. A. Zhivotovsky, L. Altenberg, L. Altenberg, Lee Altenberg, M. Iosifescu, M. Lynch, M. Lynch, M. W. Feldman, M. W. Feldman, M. W. Feldman, M. W. Feldman, M. W. Feldman, M. W. Hirsch, R. A. Horn, R. C. Lewontin, R. N. Brandon, R. Teague, S. Karlin, S. Karlin, S. Karlin, S. Karlin, S. Karlin, S. P. Otto, S. Whelan, U. Liberman, U. Liberman, V. Guillemin, V. Jayaswal, W. C. Salmon, W. C. Salmon, W. Feller, Z. Yang, Z. Yang   +60 more
core   +2 more sources

An efficient transient expression system for gene function analysis in rose

Plant Methods, 2017
Background Roses are widely used as garden ornamental plants and cut flowers. Rosa chinensis cv ‘Old Blush’ has been used as a model genotype in rose studies due to its contribution to recurrent flowering and tea scent traits of modern roses.
Jun Lu, Mengjuan Bai, Haoran Ren, Jinyi Liu, Changquan Wang   +4 more
doaj   +1 more source

The genetic code degeneracy and the amino acids chemical composition are connected [PDF]

Neuroquantology, Vol.7, 1, 181-187, 2009, 2009
We show that our recently published Arithmetic Model of the genetic code based on Godel Encoding is robust against symmetry transformations, specially Rumer s one U > G, A > C, and constitutes a link between the degeneracy structure and the chemical composition of the 20 canonical amino acids.
arxiv  

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

Molecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink, Leon W. M. M. Terstappen, Eshwari Dathathri, Khrystany Isebia, Jaco Kraan, John Martens, Ruchi Bansal   +6 more
wiley   +1 more source

APPLYING TOGAF-BASED ENTERPRISE ARCHITECTURE IN THE HEALTHCARE SECTOR: A CASE STUDY OF THE NATIONAL CENTER FOR DIABETES IN JORDAN

Jordanian Journal of Computers and Information Technology
Technology implementation can significantly benefit organizations, but ensuring it aligns with their business needs and goals is crucial. Adopting an enterprise architecture approach can aid healthcare enterprises in overcoming challenges during the ...
Hania Al Omari, Abedalrhman Alkhateeb, Bassam Hammo   +2 more
doaj   +1 more source