Results 101 to 110 of about 2,830,856 (315)

Characterization of myeloproliferative neoplasms based on genetics only and prognostication of transformation to blast phase [PDF]

, 2023
Manja Meggendorfer, Wencke Walter, Niroshan Nadarajah, Stephan Hütter, Heiko Müller, Claudia Haferlach, Wolfgang Kern, Torsten Haferlach   +7 more
openalex   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

A review of knowledge of the potential impacts of GMOs on organic agriculture [PDF]

, 2001
The organic movement believes that organic agriculture, by its nature, cannot involve the use of genetically modified organisms (GMOs). This has been incorporated into EU regulations which state that there is no place in organic agriculture for GMOs ...
Clarke, Belinda, Dale, Phillip, Fontes, Eliana, Martin, Wolfe, Pearce, Bruce, Welsh, James   +5 more
core  

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Virus-induced gene silencing: empowering genetics in non-model organisms

Journal of Experimental Botany, 2018
Virus-induced gene silencing (VIGS) is an RNA interference-based technology used to transiently knock down target gene expression by utilizing modified plant viral genomes.
A. B. Dommes, T. Gross, D. Herbert, Kimmo I Kivivirta, A. Becker   +4 more
semanticscholar   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

From genetics to therapy: Unraveling the complexities of Richter transformation in chronic lymphocytic leukemia [PDF]

, 2023
Pau Abrisqueta, Ferran Nadeu, Jan Bosch‐Schips, Gloria Iacoboni, Ángel Serna, Alba Cabirta, Lucrecia Yáñez, Leticia Quintanilla-Martı́nez, Francesc Bosch   +8 more
openalex   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

The early life microbiome of giant grouper (Epinephelus lanceolatus) larvae in a commercial hatchery is influenced by microorganisms in feed

Animal Microbiome
Fish health, growth and disease is intricately linked to its associated microbiome. Understanding the influence, source and ultimately managing the microbiome, particularly for vulnerable early life-stages, has been identified as one of the key ...
Jin Yan Lim, Yun Kit Yeoh, Maximiliano Canepa, Richard Knuckey, Dean R. Jerry, David G. Bourne   +5 more
doaj   +1 more source

PhaseTypeR: phase-type distributions in R with reward transformations and a view towards population genetics [PDF]

, 2022
Iker Rivas-González, Lars Nørvang Andersen, Asger Hobolth   +2 more
openalex   +1 more source