Results 121 to 130 of about 2,898,627 (344)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Air investigation of some alternative methods to agrobacterium and protoplast transformation for introducing exogenous genes into plants, based on the use of pollen as a vector [PDF]

, 1987
Some of the problems involved in the search for alternative plant transformation vectors have been examined. In particular the use of pregerminated pollen as a direct transformation vector has been investigated.
Morris, S.R.
core  

Rice Genetics IV [PDF]

, 2019
In these proceedings of the Fourth International Rice Genetics Symposium held in October 2000 at the International Rice Research Institute, renowned geneticists have contributed to a wide range of topics - from the most advanced research on sequencing of
Brar, D.S., Khush, G.S., Hardy, B.
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Rice Pi5-Mediated Resistance to Magnaporthe oryzae Requires the Presence of Two Coiled-Coil-Nucleotide-Binding-Leucine-Rich Repeat Genes [PDF]

, 2009
Rice blast, caused by the fungus Magnaporthe oryzae, is one of the most devastating diseases of rice. To Understand the molecular basis of PO mediated resistance to M.
Seo, Young-Su, Cao, Pei-Jian, Wang, Guo-Liang, An, Gynheung, Song, Min-Young, Wang, GL, Young-Su Seo, Ronald, Pamela, Ko, S, Jeon, JS, Kim, HK, Jeon, Jong-Seong, Sang-Kyu Lee, Yi, Gihwan, Pei-Jian Cao, Sichul Lee, Pamela Ronald, Kim, Hye-Kyung, Lee, S, Guo-Liang Wang, Song, MY, An, G, Seho Ko, Lee, Sichul, Suh, Jung-Pil, Seo, YS, Roh, Jae-Hwan, Jae-Hwan Roh, Cao, PJ, Gynheung An, Gihwan Yi, Jong-Seong Jeon, Roh, JH, Min-Young Song, Lee, SK, Hye-Kyung Kim, Hahn, Tae-Ryong, Yi, G, Ronald, P, Lee, Sang-Kyu, Suh, JP, Hahn, TR, Ko, Seho, Jung-Pil Suh, Tae-Ryong Hahn   +44 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Use of pre-transformation to cope with outlying values in important candidate genes [PDF]

, 2010
Outlying values in predictors often strongly affect the results of statistical analyses in high-dimensional settings. Although they frequently occur with most high-throughput techniques, the problem is often ignored in the literature. We suggest to use a
Willi, Sauerbrei, Boulesteix, Anne-Laure, Vincent, Guillemot   +2 more
core   +1 more source

Environmentally relevant lanthanum chloride exposure induces hepatic steatosis in zebrafish larvae via PPARα-dependent ApoB suppression

Communications Biology
Lanthanum (La), the second most produced rare earth element, is detected in various environmental and human samples. Epidemiological studies have reported a strong association between La exposure and liver injury.
Keying Li, Xinying Zhao, Zhuoyi Xie, Qiuchen Wu, Wenlu Jia, Xiangrong Zhou, Xiang Gao, Ping Zeng, Jing Li, Qiao Niu, Zhipeng Qi, Mengqiao Cui, Weiyi Song   +12 more
doaj   +1 more source

Virus-induced gene silencing: empowering genetics in non-model organisms

Journal of Experimental Botany, 2018
Virus-induced gene silencing (VIGS) is an RNA interference-based technology used to transiently knock down target gene expression by utilizing modified plant viral genomes.
A. B. Dommes, T. Gross, D. Herbert, Kimmo I Kivivirta, A. Becker   +4 more
semanticscholar   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source