Results 171 to 180 of about 439,059 (350)

Validation of a clinical-genetics score to predict hemorrhagic transformations after rtPA

, 2019
Caty Carrera, Natàlia Cullell, Nuria P. Torres‐Aguila, Elena Muiño, Alejandro Bustamante, Antonio Dávalos, Elena López‐Cancio, Marc Ribó, Carlos A. Molina, Eva Giralt‐Steinhauer, Carolina Soriano‐Tárraga, Marina Mola-Caminal, Jordi Jiménez‐Conde, Jaume Roquer, Cristòfol Vives-Bauzà, Rosa Díaz-Navarro, Vı́ctor Obach, Juan F. Arenillas, Tomás Segura, Gemma Serrano‐Heras, Joan Martí‐Fàbregas, Marimar Freijó, Juan Antonio Cabezas, Turgut Tatlisumak, Laura Heitsch, Laura Ibáñez, Carlos Cruchaga, Jin‐Moo Lee, Daniel Strbian, Joan Montaner, Israel Fernández‐Cadenas   +30 more
openalex   +2 more sources

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

Plantago species are emerging model organisms for functional genomics and stress biology. [PDF]

Plant Cell Rep
Levengood H, Smith L, Gillis S, Zhou Y, Zhang C.   +4 more
europepmc   +1 more source

A DIA‐MS‐based proteomics approach to find potential serum prognostic biomarkers in glioblastoma patients

Molecular Oncology, EarlyView.
A DIA‐MS‐based proteomics analysis of serum samples from GB patients and healthy controls showed that high levels of IL1R2 and low levels of CRTAC1 and HRG in serum are associated with poor survival outcomes for GB patients. These circulating proteins could serve as biomarkers for the prediction of outcome in patients with GB.
Anne Clavreul, François Guillonneau, Odile Blanchet, Hamza Lasla, Audrey Rousseau, Catherine Guette, Alice Boissard, Cécile Henry, Morgan Dhondt, Pascal Jézéquel, Philippe Menei, Jean‐Michel Lemée   +11 more
wiley   +1 more source

Genetic mapping of loci affecting embryogenic callus formation and in vitro regeneration in cereals and leguminous crops. [PDF]

Vavilovskii Zhurnal Genet Selektsii
Potokina ЕК, Sushchenko AS.
europepmc   +1 more source

Endoglin mediates the tumor‐ and metastasis‐promoting traits of stromal myofibroblasts in human breast carcinomas

Molecular Oncology, EarlyView.
Carcinoma‐associated fibroblasts (CAFs) in tumors influence cancer progression. We identified endoglin (ENG) as a key factor in TGF‐β signaling in myofibroblastic CAFs (myCAFs), linked to poor breast cancer outcomes. Inhibiting ENG on myCAFs suppressed the TGF‐β‐Smad2/3 pathway, reducing primary tumor growth and metastasis.
Shoki Okubo, Yoshihiro Mezawa, Zixu Wang, Ahmet Acar, Yasuhiko Ito, Atsushi Takano, Yohei Miyagi, Tomoyuki Yokose, Toshinari Yamashita, Yataro Daigo, Takuya Shirakihara, Akira Orimo   +11 more
wiley   +1 more source

Escaping endogenous miRNA post-transcriptional silencing of <i>JrGRF4b</i> enhanced transformation efficiency in woody plants. [PDF]

Front Plant Sci
Li B, Pan M, Wu D, Zheng Z, Pei D.
europepmc   +1 more source

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

Molecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková, Marie Ehrlichová, Alžběta Spálenková, Ivona Krus, Simona Šůsová, Viktor Hlaváč, Vlasta Němcová, Renata Koževnikovová, Markéta Trnková, David Vrána, Jiří Gatěk, Kateřina Kopečková, Marcela Mrhalová, Soňa Měšťáková, Pavel Souček   +14 more
wiley   +1 more source

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

Molecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim, Sungwoo Bae, Jaeyong Choi, Sun‐Wha Im, Bukyoung Cha, Gyeongseo Jung, Sun Wook Cho, Eul‐Ju Seo, Young Ah Lee, Jin Chul Paeng, Young Joo Park, Jong‐Il Kim   +11 more
wiley   +1 more source

Molecular validation of genetically transformed Catharanthus roseus plants via different strains of Agrobacterium tumefaciens

Heliyon
Medical plants play a crucial role in the pharmaceutical industry due to their natural synthesis of active compounds. Synthetic methods exist, which provide fewer effective molecules compared to those naturally occurring.
Rania El-Tanbouly, Hend Hassan, Lojina M. Awd, Azza Ali Makhlouf, Hani G. Shalabi, Sarah El-Messeiry   +5 more
doaj