Results 201 to 210 of about 2,761,227 (359)

Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation

Molecular Oncology, EarlyView.
Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides, Sara Cristobal‐Vargas, Cristina De Ramón, Elizabeta A. Rojas, Irena Misiewicz‐Krzeminska, Isabel Isidro, José Juan Pérez, Bruno Paiva, Noemi Puig, Miguel Alcoceba, María‐Victoria Mateos, Luis A. Corchete, Myriam Cuadrado, Norma C. Gutiérrez   +13 more
wiley   +1 more source

Rapid one-step CRISPR-cas vector assembly by isothermal spacer removal linearization and sequence-ligation independent cloning (ISRL-SLIC). [PDF]

MethodsX
Madsen CK, Hanak T, Aronsson H, Brinch-Pedersen H.   +3 more
europepmc   +1 more source

Validation of a clinical-genetics score to predict hemorrhagic transformations after rtPA

, 2019
Caty Carrera, Natàlia Cullell, Nuria P. Torres‐Aguila, Elena Muiño, Alejandro Bustamante, Antonio Dávalos, Elena López‐Cancio, Marc Ribó, Carlos A. Molina, Eva Giralt‐Steinhauer, Carolina Soriano‐Tárraga, Marina Mola-Caminal, Jordi Jiménez‐Conde, Jaume Roquer, Cristòfol Vives-Bauzà, Rosa Díaz-Navarro, Vı́ctor Obach, Juan F. Arenillas, Tomás Segura, Gemma Serrano‐Heras, Joan Martí‐Fàbregas, Marimar Freijó, Juan Antonio Cabezas, Turgut Tatlisumak, Laura Heitsch, Laura Ibáñez, Carlos Cruchaga, Jin‐Moo Lee, Daniel Strbian, Joan Montaner, Israel Fernández‐Cadenas   +30 more
openalex   +2 more sources

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

Molecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li, Zhijie Cao, Haiyan Xing, Zhenya Xue, Wenbing Liu, Jiayuan Chen, Yihan Mei, Runxia Gu, Hui Wei, Shaowei Qiu, Min Wang, Qing Rao, Jianxiang Wang   +12 more
wiley   +1 more source

Epigenome and three-dimensional genome architecture remodeling during NDM29-mediated retro-transformation of neuroblastoma cells. [PDF]

PLoS One
Baldini F, Pagano A, Zeaiter L, Bianchini P, Zbeeb H, Diaspro A, Vergani L.   +6 more
europepmc   +1 more source

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Establishment of a CRISPR/Cas9 gene editing system based on growth points transformation method in Fraxinus mandshurica. [PDF]

BMC Plant Biol
Li L, Wang Y, Yang F, Li W, Wang Q, Xu X, Wu Y, Ji X.   +7 more
europepmc   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Correction: Analysis and validation of novel biomarkers related to palmitoylation in adenomyosis. [PDF]

Front Genet
Zhang H, Li Y, Cao H, Zhao Y, Zhu H, Qin T.   +5 more
europepmc   +1 more source