Results 31 to 40 of about 2,830,856 (315)

Unraveling the genetics of transformed splenic marginal zone lymphoma

Blood Advances, 2023
Key Points • SMZL transformation is associated with genomic complexity and distinct genomic alterations (TNFAIP3, CDKN2A/B, TP53, and 6p+).• KLF2 mutations and complex karyotypes in transformed SMZL confer a shorter survival.
M. Grau, C. López, A. Navarro, G. Frigola, F. Nadeu, G. Clot, G. Bastidas, M. Alcoceba, M. Baptista, M. Blanes, D. Colomer, D. Costa, E. Domingo-Domènech, A. Enjuanes, L. Escoda, P. Forcada, E. Giné, M. López-Guerra, Olga Ramón, A. Rivas-Delgado, L. Vicente-Folch, A. Wotherspoon, F. Climent, E. Campo, A. López-Guillermo, E. Matutes, S. Beá   +26 more
semanticscholar   +1 more source

Single-cell analyses define a continuum of cell state and composition changes in the malignant transformation of polyps to colorectal cancer

Nature Genetics, 2021
To chart cell composition and cell state changes that occur during the transformation of healthy colon to precancerous adenomas to colorectal cancer (CRC), we generated single-cell chromatin accessibility profiles and single-cell transcriptomes from 1 ...
Winston R. Becker, Stephanie A. Nevins, Derek C. Chen, R. Chiu, Aaron M. Horning, Tuhin K. Guha, Rozelle Laquindanum, M. Mills, H. Chaib, U. Ladabaum, T. Longacre, Jeanne Shen, E. Esplin, Anshul B Kundaje, J. Ford, C. Curtis, M. Snyder, W. Greenleaf   +17 more
semanticscholar   +1 more source

Overlapping Features of Psoriasis and Atopic Dermatitis: From Genetics to Immunopathogenesis to Phenotypes

International Journal of Molecular Sciences, 2022
Psoriasis (PSO) and atopic dermatitis (AD) were once considered to be mutually exclusive diseases, but gradually regarded as a spectrum of disease. Shared genetic loci of both diseases were noted in some populations, including Chinese.
Y. Tsai, T. Tsai
semanticscholar   +1 more source

Melanophore migration and survival during zebrafish adult pigment stripe development require the immunoglobulin superfamily adhesion molecule Igsf11. [PDF]

, 2012
The zebrafish adult pigment pattern has emerged as a useful model for understanding the development and evolution of adult form as well as pattern-forming mechanisms more generally.
Eom, Dae Seok, Gordon, Tiffany N, Inoue, Shinya, Kondo, Shigeru, Parichy, David M, Patterson, Larissa B, Slingwine, Rebecca, Watanabe, Masakatsu   +7 more
core   +6 more sources

Malignant Transformation of Giant Cell Tumour of Bone: A Review of Literature and the Experience of a Referral Centre

International Journal of Molecular Sciences, 2022
Giant cell tumour of bone (GCTB) is a benign, locally aggressive primary bone neoplasm that represents 5% of all bone tumours. The principal treatment approach is surgery.
S. Vari, Federica Riva, C. E. Onesti, A. Cosimati, D. Renna, R. Biagini, Jacopo Baldi, C. Zoccali, V. Anelli, A. Annovazzi, R. Covello, A. Ascione, B. Casini, V. Ferraresi   +13 more
semanticscholar   +1 more source

PheNominal: an EHR-integrated web application for structured deep phenotyping at the point of care

BMC Medical Informatics and Decision Making, 2022
Background Clinical phenotype information greatly facilitates genetic diagnostic interpretations pipelines in disease. While post-hoc extraction using natural language processing on unstructured clinical notes continues to improve, there is a need to ...
James M. Havrilla, Anbumalar Singaravelu, Dennis M. Driscoll, Leonard Minkovsky, Ingo Helbig, Livija Medne, Kai Wang, Ian Krantz, Bimal R. Desai   +8 more
doaj   +1 more source

The combination of morphogenic regulators BABY BOOM and GRF-GIF improves maize transformation efficiency

bioRxiv, 2022
Transformation is an indispensable tool for plant genetics and functional genomic studies. Although stable transformation no longer represents a major technology bottleneck in maize, there is still need for easily accessible and efficient transformation ...
Zongliang Chen, J. Debernardi, J. Dubcovsky, A. Gallavotti   +3 more
semanticscholar   +1 more source

The molecular basis of T cell acute lymphoblastic leukemia [PDF]

, 2012
T cell acute lymphoblastic leukemias (T-ALLs) arise from the malignant transformation of hematopoietic progenitors primed toward T cell development, as result of a multistep oncogenic process involving constitutive activation of NOTCH signaling and ...
Adolfo Ferrando, Bash, Bash, Chen, Condorelli, Dube, Fisch, Hagemeijer, Hebert, Ho, Kelliher, Kikuchi, Larson, Lu, McGuire, McGuire, Nagel, Ntziachristos, Ntziachristos, Ono, Pieter Van Vlierberghe, Royer-Pokora, Rubnitz, van Grotel   +23 more
core   +1 more source

The EM Algorithm and the Rise of Computational Biology [PDF]

, 2010
In the past decade computational biology has grown from a cottage industry with a handful of researchers to an attractive interdisciplinary field, catching the attention and imagination of many quantitatively-minded scientists.
Citable Link, Jun S. Liu, Xiaodan Fan, Yuan Yuan   +3 more
core   +3 more sources

First Steps towards Underdominant Genetic Transformation of Insect Populations [PDF]

, 2014
The idea of introducing genetic modifications into wild populations of insects to stop them from spreading diseases is more than 40 years old. Synthetic disease refractory genes have been successfully generated for mosquito vectors of dengue fever and ...
AG Clark, AH Brand, Alexander W. E. Franz, AT Isaacs, AWE Franz, C Curtis, CH Chen, CL Holley, D-U Kim, E Enerly, Floyd A. Reed, J Bischof, Jai A. Denton, Jarosław Bryk, JB Duffy, JM Marshall, K Ito, K Williams, LB Weinstein, M Ràmia, N Barton, N Jasinskiene, N Windbichler, Philipp M. Altrock, PM Altrock, PM Altrock, R. Guy Reeves, RD Seager, RK Cook, S Cherry, S Davis, S Saebøe-Larssen, S Wilks, S Wright, SJ Marygold, SJ Marygold, SP Sinkins, SS Wilks, T Nolan, TW Scott, V Kokoza, VR Chintapalli, Y Dong   +42 more
core   +9 more sources