Results 101 to 110 of about 2,586,842 (344)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

TRANSFORMATION OF FAMILY IN MODERN RUSSIAN SOCIETY

Sovremennye Issledovaniâ Socialʹnyh Problem, 2014
The article examines concept of family in Russian society, changes in interpretation of family, connected with modern tendencies and processes in different sociocultural spheres.
Olga Anatolevna Otradnova
doaj   +1 more source

Accelerating innovation development and scaling processes for agricultural transformation [PDF]

, 2020
At the 5th Global Science Conference on Climate-Smart Agriculture in Bali, CCAFS, IFAD and USDA-FAS organized the Side event “Accelerating innovation development and scaling climate-smart agriculture to drive a transformation in food systems”. High-level
Corner-Dolloff, Caitlin, Dinesh, Dhanush, Firmian, Ilaria, Koerner, Jana   +3 more
core  

In the balance? Civil society and the peace process 2002-2008 [PDF]

, 2010
As Sri Lanka slid back towards open hostilities in 2006, existing patterns of civil society engagement in peace negotiations came under widespread criticism on the grounds that they had failed to broaden participation and that they had largely excluded ...
Saravanamuttu, Pakiasothy, Walton, Oliver   +1 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Cinema of the Desert: The Fight of the Ascetic Women

Religions
This paper examines the cinematic portrayals of ascetic women within contemporary film. Historically, the early desert fathers and mothers are venerated figures who embody a life of ascesis—spiritual discipline amidst the deserts of Egypt, Palestine, and
Milja Radovic
doaj   +1 more source

Magnetic energy harvesting and concentration at distance by transformation optics [PDF]

, 2012
Magnetic energy is one the main agents powering our society: generating energy in power plants, keeping information in magnetic memories, moving our devices with motors. All of these applications require a certain spatial distribution of magnetic energy,
Camps, Jordi-Prat, Navau, Carles, Sanchez, Alvaro   +2 more
core   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

“Your identity is, what God puts into you”—Christian online activism on gender and sexuality politics on TikTok

Frontiers in Political Science
Christian and right-wing actors have been able to push their agenda, which includes the idea of Christian supremacy and fundamentalist views on sexual orientation, gender relations, reproductive rights and family concepts, toward the political center in ...
Michael Hunklinger, Katharina Limacher
doaj   +1 more source

Transformation of the information sphere of civil society

RUDN journal of Sociology, 2019
The author considers new phenomena in the information sphere of civil society, their influence on the nature and forms of its development, emphasizing that the development of the Russian civil society follows the general formation of the global civil ...
V K Levashov
doaj   +1 more source