Results 91 to 100 of about 2,107,464 (275)

Physical parameters and basis transformations in the Two-Higgs-Doublet model

, 2008
A direct connection between physical parameters of general Two-Higgs-Doublet Model (2HDM) potentials after electroweak symmetry breaking (EWSB) and the parameters that define the potentials before EWSB is established.
C. C. Nishi, P. M. Ferreira
core   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Hamiltonian Formalism of the de-Sitter Invariant Special Relativity

, 2005
Lagrangian of the Einstein's special relativity with universal parameter $c$ ($\mathcal{SR}_c$) is invariant under Poincar\'e transformation which preserves Lorentz metric $\eta_{\mu\nu}$.
, C.L. Bennett, Edward A. Desloge, G. Amelino-Camelia, H.Y. Guo, H.Y. Guo, Huang Wei, J. Kowalski-Glikman, K.H. Look, K.H. Look (Q.K. Lu), L.D. Landau, Li Si, M. Tegmark, See, Xiao Neng-Chao, Yan Mu-Lin   +15 more
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

COORDINATE TRANSFORMATION USING THE LEAST SQUARES METHOD: A CASE STUDY ON TRABZON, TURKEY [PDF]

Geodetski Glasnik
The ED50 datum uses the Hayford ellipsoid and the Greenwich meridian as the prime meridian. In Turkey, the ED50 datum with the Hayford ellipsoid was used until 2001, after which the ITRF datum with the GRS80 ellipsoid became the standard.
Nazan Yilmaz
doaj   +1 more source

Prototyping Virtual Data Technologies in ATLAS Data Challenge 1 Production

, 2003
For efficiency of the large production tasks distributed worldwide, it is essential to provide shared production management tools comprised of integratable and interoperable services.
De, K., Malon, D., Nevski, P., Vaniachine, A.   +3 more
core  

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

The Floquet-Lyapunov transformation for fractional discrete-time linear systems with periodic parameters [PDF]

Archives of Control Sciences
The Floquet-Lyapunov transformation is extended to fractional discrete-time linear systems with periodic parameters. A procedure for computation of the transformation is proposed and illustrated by a numerical example.
Tadeusz Kaczorek, Andrzej Ruszewski
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source