Results 71 to 80 of about 561,734 (311)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

THE ROLE OF GLOTTAL SOURCE PARAMETERS FOR HIGH-QUALITY TRANSFORMATION OF PERCEPTUAL AGE [PDF]

, 2020
The intuitive control of voice transformation (e.g., age/sex, emotions) is useful to extend the expressive repertoire of a voice. This paper explores the role of glottal source parameters for the control of voice transformation.
Xavier Favory, Nicolas Obin, Gilles Degottex, Axel Roebel   +3 more
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Genetic parameters for somatic cell score according to udder infection status in Valle del Belice dairy sheep and impact of imperfect diagnosis of infection [PDF]

, 2010
Background Somatic cell score (SCS) has been promoted as a selection criterion to improve mastitis resistance. However, SCS from healthy and infected animals may be considered as separate traits.
Portolano, B., Bovenhuis, H., Bovenhuis Henk, Riggio Valentina, Portolano Baldassare, Bishop, S.C., Henk Bovenhuis, Valentina Riggio, Bishop Stephen C, Riggio, Valentina; id_orcid, Bovenhuis, Henk, Baldassare Portolano, Scatassa, S., Stephen C Bishop, Bovenhuis, H, Riggio, V., RIGGIO, Valentina, Bishop, SC, Bishop, Stephen C., Portolano, Baldassare   +19 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Gnss-based coordinate transformation of The Marmara region and the determination of parameters of cellular transformation

, 2010
Türkiye'de 1932 yılında başlayan temel jeodezik ağların öyküsü, 1954'te Hayford elipsoidini esas alan TUD-54 (Türkiye Ulusal Datumu) (ED50-European Datum 50) ve 1997 sonrasında ise GRS-80 elipsoidine, dolayısıyla GNSS teknolojisine dayalı TUTGA-
Ürüşan, Ahmet Yücel
core  

Dual-quaternion-based iterative algorithm of the three dimensional coordinate transformation

Earth, Planets and Space
Nowadays a unit quaternion is widely employed to represent the three-dimensional (3D) rotation matrix and then applied to the 3D similarity coordinate transformation.
Huaien Zeng, Zhihao Wang, Junfeng Li, Siyang Li, Junjie Wang, Xi Li   +5 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Pairwise Comparison Estimation of Censored Transformation Models [PDF]

In this paper a pairwise comparison estimation procedure is proposed for the regression coefficients in a censored transformation model. The main advantage of the new estimator is that it can accommodate covariate dependent censoring without the ...
Elie Tamer, Shakeeb Khan
core