Results 71 to 80 of about 2,123,374 (298)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Determination of the stretch tensor for structural transformations

, 2015
The transformation stretch tensor plays an essential role in the evaluation of conditions of compatibility between phases and the use of the Cauchy-Born rule. This tensor is difficult to measure directly from experiment.
Bailey, Bain, Ball, Ball, Ball, Bowles, Chen, Chen, Chluba, Cui, Cui, Davey, Duggin, Fonda, Huang, Ikeda, James, Kang, Kaufmann, Knowles, Knowles, Kunz, Kurdjumov, Li, Liu, Lomer, Louie, Nobumichi Tamura, Otsuka, Otsuka, Otsuka, Otsuka, Pitteri, Richard D. James, Song, Song, Srivastava, Srivastava, Tadaki, Tamura, Wayman, Xian Chen, Yintao Song, Zarnetta   +43 more
core   +2 more sources

Transformer-Based Parameter Estimation in Statistics

Mathematics
Parameter estimation is one of the most important tasks in statistics, and is key to helping people understand the distribution behind a sample of observations. Traditionally, parameter estimation is done either by closed-form solutions (e.g., maximum likelihood estimation for Gaussian distribution) or by iterative numerical methods such as the Newton ...
Xiaoxin Yin, David S. Yin
openaire   +3 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

The Effects of Some Parameters on Agrobacterium-Mediated Transformation in Muskmelon

International Journal of Horticultural Science, 1999
Some parameters involved in Agrobacterium-mediated transformation in muskmelon Hales best (HBS) were studied. Cotyledon explants excised from 3.5-day-old seedlings were co-cultivated with Agrobacterium tumefaciens harbouring binary vectors which ...
Z. Qiu, Cs. Bársony, Gy. Bisztray, I. Velich   +3 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

A Vision Based Top-View Transformation Model for a Vehicle Parking Assistant

Sensors, 2012
This paper proposes the Top-View Transformation Model for image coordinate transformation, which involves transforming a perspective projection image into its corresponding bird’s eye vision.
Chien-Chuan Lin, Ming-Shi Wang
doaj   +1 more source

Transformation Acoustics in Generic Elastic Media [PDF]

, 2012
In this work a transformation acoustics scheme for generic elastic media is developed. Our approach starts form the decomposition of the elasticity tensor in terms of its eigentensors, an idea previously used by Norris.
Bergamin, Luzi
core  

Matrix diagonalization and exact solution of the k-photon Jaynes-Cummings model

, 2018
We study and exactly solve the two-photon and k-photon Jaynes-Cummings models by using a novelty algebraic method. This algebraic method is based on the Pauli matrices realization and the tilting transformation of the $SU(2)$ group and let us diagonalize
Choreño, E., Granados, V. D., Ojeda-Guillén, D.   +2 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source