Results 91 to 100 of about 2,123,374 (298)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
The review and development of a modern GNSS network and datum in Uzbekistan
Geodesy and Geodynamics, 2017 This study is focused on the discussion of a modern GNSS network and datum in Uzbekistan. Considering the significance difference (up to 200 m) in positions of the local ellipsoidal datum and the global datum, the precise transformation parameters ...
Dilbarkhon Fazilova
doaj +1 more source
Estimation of a semiparametric transformation model
, 2008 This paper proposes consistent estimators for transformation parameters in semiparametric models. The problem is to find the optimal transformation into the space of models with a predetermined regression structure like additive or multiplicative ...
Linton, Oliver +2 more
core +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Journal of Imaging, 2017 The line-based transformation model (LBTM), built upon the use of affine transformation, was previously proposed for image registration and image rectification. The original LBTM first utilizes the control line features to estimate six rotation and scale
Ahmed Shaker +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Quantitative Analysis of 4 × 4 Mueller Matrix Transformation Parameters for Biomedical Imaging
Photonics, 2019 Mueller matrix polarimetry is a potentially powerful technique for obtaining microstructural information of biomedical specimens. Thus, it has found increasing application in both backscattering imaging of bulk tissue samples and transmission microscopic
Wei Sheng +9 more
doaj +1 more source
Interimage matching is the process of determining the geometric transformation required to conform spatially one image to another. In principle, the parameters of that transformation are varied until some measure of some difference between the two images
Juday, R. D., Wolfe, R. H., Jr.
core +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source