Results 121 to 130 of about 1,364,752 (208)

Agency submission to the Nutrition Advisory Group

open access: yes, 1993
The Agency was established by the Government in September 1986 under the Combat Poverty Agency Act Under this Act the Agency has a statutory duty to advise and make recommendations to the Government on all aspects of economic and social planning in ...
Combat Poverty Agency (CPA)
core  

Identification and characterization of a gene conferring stress resistance in Escherichia coli and cyanobacteria

open access: yesFEBS Open Bio, EarlyView.
Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada   +7 more
wiley   +1 more source

A Transformative Approach to Admissions Assessment: The South African Case

open access: yesDesigns for Learning
School-leaving and higher education admission assessments in South Africa are typically summative and normative, comparing students for admission into university.
Robert Noel Prince, Zach Simpson
doaj   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

open access: yesFEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao   +10 more
wiley   +1 more source

In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans

open access: yesFEBS Open Bio, EarlyView.
In vitro induction of human regulatory T cells using standard protocols generates suppressive, Foxp3‐expressing CD4+ T cells independently of TGF‐β supplementation and donor age. Regulatory T (Treg) cells play a key role in immune tolerance and homeostasis.
Lynn Muller   +3 more
wiley   +1 more source

Sustainability agency in unsustainable structures: rhetoric of a capable transformative individual

open access: yesDiscover Sustainability
While sustainability as a practice has been implemented in education for a long time, the conceptualisation of an impactful sustainability actor has not been as thoroughly formulated.
Janne J. Salovaara   +1 more
doaj   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

open access: yesFEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli   +2 more
wiley   +1 more source

The praxis of transformation and adaptation to climate change: contestations in uncertain ‘marginal’ environments

open access: yesGlobal Social Challenges Journal
This article aims to examine and further develop the concept of praxis – processes to critique the status quo and search for alternatives – in relation to transformative adaptation to climate change.
Shilpi Srivastava   +8 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

open access: yesAging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

"This game cured my depression": Celeste Steam reviews as platformized community archive of transformative play

open access: yes
User-generated game reviews on the commercial digital distribution platform Steam can be productively conceptualized as a platformized community archive of player experience and reception.
Bailey, Andrew
core   +1 more source

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