Results 51 to 60 of about 9,150 (262)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Overvoltage Protection for High Frequency High Voltage Power Transformers

Eletrônica de Potência, 2019
Transformers with high-voltage operation may have undesired behavior due to the effects of their parasitic elements. In power electronics applications, if the primary voltage has harmonics, transformer resonances may be excited, causing high primary ...
Diego Teruo Mendes de Souza, Bruno Valverde, José Antenor Pomilio   +2 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Improving the Protection of Step-Down Transformers by Utilizing Percentage Differential Protection and Scale-Dependent Intrinsic Entropy

Entropy
Transformer operations are susceptible to both internal and external faults. This study primarily employed software to construct a power system simulation model featuring a step-down transformer.
Chia-Wei Huang, Chih-Chiang Fang, Wei-Tai Hsu, Chih-Chung Yang, Li-Ting Zhou   +4 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Experimentos con una protección basada en redes de neuronas artificiales

Revista Científica de Ingeniería Energética, 2011
En este trabajo se muestran los resultados de los experimentos físicos realizados con una protección basada totalmente en Redes de Neuronas Artificiales para un transformador eléctrico a escala de laboratorio.
Orlys Ernesto Torres Breffe, Luis Geovanny Maza Pinza, Marwan O. A. Mohammed, Martial Pascal Batcho   +3 more
doaj  

Low-frequency transformer protection method based on sinusoidal fitting residuals of differential currents

International Journal of Electrical Power & Energy Systems
Offshore wind power low-frequency transmission system locally presents 100% power electronics and both sides are controlled system, by the influence of bilateral power electronic power control strategy, offshore wind power low-frequency transmission ...
Shuping Gao, Zhe Quan, Xinyu Wu, Guobing Song, Chenqing Wang   +4 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Research on transformer protection based on wavelet neural network and FPGA

Journal of Measurement Science and Instrumentation, 2014
The paper expounds importance of the transformer protection and analyzes the magnetizing inrush current produce condition.A comprehensive prevention based on the wavelet neural network methods for identification the magnetizing inrush current is put ...
WANG Zhi-wen, GONG Mao-fa, AN Bin, LI Lan-bing, LIU Tao   +4 more
doaj