Results 71 to 80 of about 2,301,421 (250)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Transformer

, 2005
"transformer" steht für (Um)Gestaltung, Verwandlung und Veränderung von und durch alltägliche Produkte. Ein Raum teilendes Objekt, im Konkreten ein Paravent, verwandelt sich und wird zur Leuchte.
Kottbauer, Anton
core   +4 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Analysis of relay protection action of grounding fault of no-load charging of a 330 kV transformer

Gong-kuang zidonghua, 2013
In view of problem that a 330 kV start-up standby transformer took place relay protection action in no-load charging, the paper indicated that the action was caused by grounding fault of A-phase current transformer through analyzing charging current ...
LYU Bin, NI Sai-sai, LIU Yang, ZHONG Li-na   +3 more
doaj  

Low-frequency transformer protection method based on sinusoidal fitting residuals of differential currents

International Journal of Electrical Power & Energy Systems
Offshore wind power low-frequency transmission system locally presents 100% power electronics and both sides are controlled system, by the influence of bilateral power electronic power control strategy, offshore wind power low-frequency transmission ...
Shuping Gao, Zhe Quan, Xinyu Wu, Guobing Song, Chenqing Wang   +4 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

A Survey on Fault Clearing and Protection Technology of Power Electronic Transformer in Distribution Network

Kongzhi Yu Xinxi Jishu, 2017
Protection system for power electronic transformer is an important measure to ensure its safe and stable operation in engineering application. Firstly, taking AC-DC-AC type power electronic transformer as an example, this paper pointed out its topology ...
ZHOU Tingdong, XU Yonghai
doaj  

Development of an IoT-Based Differential Protection System for Power Transformers: A Case Study of New Enma Substation, Aden, Yemen

IEEE Access
Differential protection is the primary and fastest protection scheme for power transformers; however, its failure may lead to severe thermal and mechanical damage to the transformer.
Ali Khaled Ali Mohammed Alshurmani, Taha Mahmoud Radman, Mohammed Fadhl Abdullah   +2 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source