Results 61 to 70 of about 21,646 (293)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Pendekatan psikologi dakwah menangani histeria remaja muslim di Selangor [PDF]

, 2015
Gejala histeria dalam kalangan remaja di Malaysia merupakan epidemik sosial yang telah lama berlaku dalam masyarakat. Kejadian tersebut mengganggu proses pengajaran dan pembelajaran, psikologi, jasmani dan spiritual remaja.
Saparudin, Intan Farhana
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Simulation study on converter transformer windings stress characteristics under harmonic current and temperature rise effect

International Journal of Electrical Power & Energy Systems
High-frequency harmonic current leads to temperature increases and uneven stress distribution within ultra-high-voltage (UHV) converter transformer windings.
Jing Xu, Jian Hao, Ning Zhang, Ruijin Liao, Yun Feng, Wenlong Liao, Huanchao Cheng   +6 more
doaj   +1 more source

Method of ParametersDeterminationfor Multi-WindingTransformer Equivalent Circuitin the Form of Multi-BeamStar [PDF]

Problems of the Regional Energetics, 2018
For the case of transformer with a number of windings four or more, the number of pair short-circuit impedances are morethan the number of beams of the corresponding star, which makes it impossible to obtain a sufficiently correct equivalent scheme in ...
Suslov V.M., Bosneaga V.A.
doaj   +1 more source

A dc to dc converter [PDF]

, 1984
The object of the invention is to provide an improved converter for converting one direct current voltage to another. A plurality of phased square wave voltages are provided from a ring counter through amplifiers to a like plurality of output ...
Garrett, H., Gould, J. M., Matheney, J. L., Willis, A. E.   +3 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

INVESTIGATION OF ASYMETRIC MODES OF THREE-PHASE THREE LEGS PHASE SHIFTING TRANSFORMER WITH CONNECTION IN DELTA AND TWO ADDITIONAL WINDINGS [PDF]

Problems of the Regional Energetics, 2014
The model of power three-phase three legs phase-shifting transformer with connection in delta and two additional windings is realized. Calculations and research of steady state asymmetric modes particularities of given transformer with such windings ...
Bosneaga V.A., Suslov V.M.
doaj  

System for automatically switching transformer coupled lines [PDF]

, 1979
A system is presented for automatically controlling transformer coupled alternating current electric lines. The secondary winding of each transformer is provided with a center tap.
Dwinell, W. S.
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source